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Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase [ Mus musculus (house mouse) ]

Gene ID: 233789, updated on 8-Feb-2024

Summary

Official Symbol
Smg1provided by MGI
Official Full Name
SMG1 nonsense mediated mRNA decay associated PI3K related kinaseprovided by MGI
Primary source
MGI:MGI:1919742
See related
Ensembl:ENSMUSG00000030655 AllianceGenome:MGI:1919742
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0421; 2610207I05Rik; 5430435M13Rik; C130002K18Rik
Summary
Predicted to enable protein kinase C activity and telomeric DNA binding activity. Predicted to be involved in several processes, including TORC1 signaling; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and protein phosphorylation. Predicted to act upstream of or within DNA repair and phosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of TORC1 complex and TORC2 complex. Predicted to be active in nucleus. Is expressed in spermatid and spermatocyte. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 16.3), thymus adult (RPKM 14.4) and 28 other tissues See more
Orthologs
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Genomic context

See Smg1 in Genome Data Viewer
Location:
7 F1; 7 63.44 cM
Exon count:
64
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (117730531..117843026, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118131308..118244437, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1357 Neighboring gene ribosomal protein S15A Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125272620-125272803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125273191-125273420 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene predicted gene, 25683 Neighboring gene STARR-seq mESC enhancer starr_20001 Neighboring gene predicted gene, 40454 Neighboring gene RIKEN cDNA 4930583K01 gene Neighboring gene STARR-positive B cell enhancer ABC_E878 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:125403315-125403561 Neighboring gene predicted gene, 34999 Neighboring gene STARR-positive B cell enhancer ABC_E1358 Neighboring gene predicted gene, 23229

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase SMG1
Names
PI-3-kinase-related kinase SMG-1
SMG-1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase
lambda-interacting protein
lambda/iota protein kinase C-interacting protein
nonsense mediated mRNA decay-associated PI3K-related kinase SMG1
phosphatidylinositol 3-kinase-related protein kinase
NP_001026984.1
XP_006507740.1
XP_006507741.1
XP_030098366.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031814.1NP_001026984.1  serine/threonine-protein kinase SMG1

    See identical proteins and their annotated locations for NP_001026984.1

    Status: PROVISIONAL

    Source sequence(s)
    AC131788, AC132432
    Consensus CDS
    CCDS40102.1
    UniProtKB/Swiss-Prot
    E9QLR6, Q5DU42, Q6ZQC0, Q8BKX6, Q8BLU4, Q8BWJ5, Q8BXD3
    Related
    ENSMUSP00000032891.9, ENSMUST00000032891.15
    Conserved Domains (3) summary
    cd05170
    Location:21192424
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:36283657
    FATC; FATC domain
    pfam15785
    Location:6291240
    SMG1; Serine/threonine-protein kinase smg-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    117730531..117843026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507677.4XP_006507740.1  serine/threonine-protein kinase SMG1 isoform X1

    Conserved Domains (4) summary
    cd05170
    Location:21182423
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:36273656
    FATC; FATC domain
    pfam15785
    Location:6281239
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:30138
    DUF5303; Region of unknown function (DUF5303)
  2. XM_006507678.3XP_006507741.1  serine/threonine-protein kinase SMG1 isoform X2

    Conserved Domains (4) summary
    cd05170
    Location:20952400
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:36043633
    FATC; FATC domain
    pfam15785
    Location:6051216
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6114
    DUF5303; Region of unknown function (DUF5303)
  3. XM_030242506.1XP_030098366.1  serine/threonine-protein kinase SMG1 isoform X3

    Conserved Domains (4) summary
    cd05170
    Location:20942399
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:36033632
    FATC; FATC domain
    pfam15785
    Location:6041215
    SMG1; Serine/threonine-protein kinase smg-1
    pfam17229
    Location:6114
    DUF5303; Region of unknown function (DUF5303)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177180.2: Suppressed sequence

    Description
    NM_177180.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.