U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RRP8 ribosomal RNA processing 8 [ Homo sapiens (human) ]

Gene ID: 23378, updated on 6-Nov-2022

Summary

Official Symbol
RRP8provided by HGNC
Official Full Name
ribosomal RNA processing 8provided by HGNC
Primary source
HGNC:HGNC:29030
See related
Ensembl:ENSG00000132275 MIM:615818; AllianceGenome:HGNC:29030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NML; KIAA0409
Summary
Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RRP8 in Genome Data Viewer
Location:
11p15.4
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6595072..6603616, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6653543..6662088, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6616302..6624846, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene integrin linked kinase Neighboring gene tripeptidyl peptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0409

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables S-adenosylmethionine-dependent methyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rDNA heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect regulation of G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by glucose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of eNoSc complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
is_active_in rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal RNA-processing protein 8
Names
RRP8 methyltransferase homolog
cerebral protein 1
nucleomethylin
ribosomal RNA processing 8, methyltransferase, homolog
NP_056139.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015324.4NP_056139.1  ribosomal RNA-processing protein 8

    See identical proteins and their annotated locations for NP_056139.1

    Status: VALIDATED

    Source sequence(s)
    AB007869, AC009796, BC001071, BX417992, R51624
    Consensus CDS
    CCDS31411.1
    UniProtKB/Swiss-Prot
    O43159, Q9BVM6
    Related
    ENSP00000254605.6, ENST00000254605.11
    Conserved Domains (1) summary
    pfam05148
    Location:242456
    Methyltransf_8; Hypothetical methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6595072..6603616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6653543..6662088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)