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RRP8 ribosomal RNA processing 8 [ Homo sapiens (human) ]

Gene ID: 23378, updated on 9-Feb-2020

Summary

Official Symbol
RRP8provided by HGNC
Official Full Name
ribosomal RNA processing 8provided by HGNC
Primary source
HGNC:HGNC:29030
See related
Ensembl:ENSG00000132275 MIM:615818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NML; KIAA0409
Expression
Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues See more
Orthologs

Genomic context

See RRP8 in Genome Data Viewer
Location:
11p15.4
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6514830..6603678, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6621144..6624884, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene integrin linked kinase Neighboring gene tripeptidyl peptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0409

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
S-adenosylmethionine-dependent methyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing at rDNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing at rDNA IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing at rDNA TAS
Traceable Author Statement
more info
 
intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by glucose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosomal RNA-processing protein 8
Names
RRP8 methyltransferase homolog
cerebral protein 1
nucleomethylin
ribosomal RNA processing 8, methyltransferase, homolog
NP_056139.1
XP_011518257.1
XP_016872912.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015324.4NP_056139.1  ribosomal RNA-processing protein 8

    See identical proteins and their annotated locations for NP_056139.1

    Status: VALIDATED

    Source sequence(s)
    AB007869, AC009796, BC001071, BX417992, R51624
    Consensus CDS
    CCDS31411.1
    UniProtKB/Swiss-Prot
    O43159
    Related
    ENSP00000254605.6, ENST00000254605.11
    Conserved Domains (1) summary
    pfam05148
    Location:242456
    Methyltransf_8; Hypothetical methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6514830..6603678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519955.2XP_011518257.1  ribosomal RNA-processing protein 8 isoform X1

    Conserved Domains (2) summary
    COG0500
    Location:299422
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:242417
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017017423.2XP_016872912.1  ribosomal RNA-processing protein 8 isoform X2

    Conserved Domains (1) summary
    pfam05148
    Location:1215
    Methyltransf_8; Hypothetical methyltransferase

RNA

  1. XR_930859.1 RNA Sequence

  2. XR_930858.1 RNA Sequence

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