Format

Send to:

Choose Destination

LARP1 La ribonucleoprotein 1, translational regulator [ Homo sapiens (human) ]

Gene ID: 23367, updated on 5-Jul-2020

Summary

Official Symbol
LARP1provided by HGNC
Official Full Name
La ribonucleoprotein 1, translational regulatorprovided by HGNC
Primary source
HGNC:HGNC:29531
See related
Ensembl:ENSG00000155506 MIM:612059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LARP; Lar1; Lhp1
Expression
Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues See more
Orthologs

Genomic context

See LARP1 in Genome Data Viewer
Location:
5q33.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (154682979..154817605)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154062224..154197167)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 3141 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4044 Neighboring gene microRNA 1303 Neighboring gene RNA, 7SL, cytoplasmic 803, pseudogene Neighboring gene ribosomal protein L21 pseudogene 57 Neighboring gene uncharacterized LOC112267936 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene CCR4-NOT transcription complex subunit 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated La ribonucleoprotein domain family, member 1 (LARP1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with La ribonucleoprotein domain family, member 1 (LARP1) is identified in a series of six affinity purification/mass spectrometry screens PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0731, MGC19556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA 7-methylguanosine cap binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
RNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
eukaryotic initiation factor 4E binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
translation activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation initiation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to rapamycin IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
colocalizes_with polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
la-related protein 1
Names
La ribonucleoprotein domain family member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367713.1NP_001354642.1  la-related protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
  2. NM_001367714.1NP_001354643.1  la-related protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
  3. NM_001367715.1NP_001354644.1  la-related protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
  4. NM_001367716.1NP_001354645.1  la-related protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
  5. NM_001367717.1NP_001354646.1  la-related protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008379, AC112169
  6. NM_001367718.1NP_001354647.1  la-related protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC112169
  7. NM_001367719.1NP_001354648.1  la-related protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112169
  8. NM_015315.5NP_056130.2  la-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056130.2

    Status: VALIDATED

    Source sequence(s)
    AB018274, AC008379, BC001460, BC038220, BQ422667
    Consensus CDS
    CCDS4328.1
    UniProtKB/Swiss-Prot
    Q6PKG0
    Related
    ENSP00000336721.4, ENST00000336314.9
    Conserved Domains (4) summary
    smart00684
    Location:849887
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:327399
    LARP_1; La RNA-binding domain of La-related protein 1
    cl25751
    Location:123535
    DUF4045; Domain of unknown function (DUF4045)
    cl26464
    Location:11251
    Atrophin-1; Atrophin-1 family
  9. NM_033551.3NP_291029.2  la-related protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112169

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    154682979..154817605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714775.2XP_006714838.1  la-related protein 1 isoform X7

    Conserved Domains (2) summary
    smart00684
    Location:785823
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:263335
    LARP_1; La RNA-binding domain of La-related protein 1
  2. XM_011537616.1XP_011535918.1  la-related protein 1 isoform X5

    Conserved Domains (2) summary
    smart00684
    Location:818856
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:296368
    LARP_1; La RNA-binding domain of La-related protein 1
  3. XM_011537614.1XP_011535916.1  la-related protein 1 isoform X2

    Conserved Domains (3) summary
    smart00684
    Location:900938
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:378450
    LARP_1; La RNA-binding domain of La-related protein 1
    COG5193
    Location:177529
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
  4. XM_011537615.1XP_011535917.1  la-related protein 1 isoform X4

    Conserved Domains (3) summary
    smart00684
    Location:859897
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:337409
    LARP_1; La RNA-binding domain of La-related protein 1
    COG5193
    Location:211488
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
  5. XM_005268408.3XP_005268465.1  la-related protein 1 isoform X8

    See identical proteins and their annotated locations for XP_005268465.1

    Conserved Domains (2) summary
    smart00684
    Location:721759
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:199271
    LARP_1; La RNA-binding domain of La-related protein 1
  6. XM_011537617.1XP_011535919.1  la-related protein 1 isoform X6

    Conserved Domains (2) summary
    smart00684
    Location:791829
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08037
    Location:269341
    LARP_1; La RNA-binding domain of La-related protein 1
Support Center