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ZNF629 zinc finger protein 629 [ Homo sapiens (human) ]

Gene ID: 23361, updated on 23-Nov-2021

Summary

Official Symbol
ZNF629provided by HGNC
Official Full Name
zinc finger protein 629provided by HGNC
Primary source
HGNC:HGNC:29008
See related
Ensembl:ENSG00000102870 MIM:619587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; ZNF65
Expression
Ubiquitous expression in heart (RPKM 5.1), brain (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF629 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30778456..30787205, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30789777..30798526, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Snf2 related CREBBP activator protein Neighboring gene transmembrane protein 265 Neighboring gene phosphorylase kinase catalytic subunit gamma 2 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40 Neighboring gene chromosome 20 open reading frame 27 pseudogene Neighboring gene BAF chromatin remodeling complex subunit BCL7C Neighboring gene microRNA 4519

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 629
Names
DNA-binding protein
zinc finger protein 65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080417.3NP_001073886.1  zinc finger protein 629

    See identical proteins and their annotated locations for NP_001073886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC106886
    Consensus CDS
    CCDS45463.1
    UniProtKB/Swiss-Prot
    Q9UEG4
    Related
    ENSP00000262525.4, ENST00000262525.6
    Conserved Domains (4) summary
    COG5048
    Location:146521
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:180200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:402424
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:472497
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001345970.2NP_001332899.1  zinc finger protein 629 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC106886
    UniProtKB/Swiss-Prot
    Q9UEG4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30778456..30787205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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