Format

Send to:

Choose Destination

USP24 ubiquitin specific peptidase 24 [ Homo sapiens (human) ]

Gene ID: 23358, updated on 3-May-2020

Summary

Official Symbol
USP24provided by HGNC
Official Full Name
ubiquitin specific peptidase 24provided by HGNC
Primary source
HGNC:HGNC:12623
See related
Ensembl:ENSG00000162402 MIM:610569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 9.9), lymph node (RPKM 9.7) and 25 other tissues See more
Orthologs

Genomic context

See USP24 in Genome Data Viewer
Location:
1p32.3
Exon count:
73
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (55066359..55215374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55532032..55681039, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene proprotein convertase subtilisin/kexin type 9 Neighboring gene uncharacterized LOC100507634 Neighboring gene MIR4422 host gene Neighboring gene glycogenin 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
NHGRI GWA Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31309, KIAA1057

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 24
Names
deubiquitinating enzyme 24
ubiquitin specific protease 24
ubiquitin thioesterase 24
ubiquitin thiolesterase 24
ubiquitin-specific processing protease 24
NP_056121.2
XP_005270747.1
XP_016856320.1
XP_016856321.1
XP_016856322.1
XP_016856323.1
XP_016856324.1
XP_016856325.1
XP_016856326.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015306.3NP_056121.2  ubiquitin carboxyl-terminal hydrolase 24

    See identical proteins and their annotated locations for NP_056121.2

    Status: VALIDATED

    Source sequence(s)
    AC091609
    Consensus CDS
    CCDS44154.2
    UniProtKB/Swiss-Prot
    Q9UPU5
    Related
    ENSP00000294383.5, ENST00000294383.7
    Conserved Domains (3) summary
    cd02659
    Location:16872044
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14286
    Location:642
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    pfam00443
    Location:16892039
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    55066359..55215374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000832.1XP_016856321.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

  2. XM_017000831.1XP_016856320.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

  3. XM_017000834.1XP_016856323.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

  4. XM_017000833.1XP_016856322.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

  5. XM_005270690.3XP_005270747.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

    Conserved Domains (2) summary
    cd02659
    Location:10921449
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:10941444
    UCH; Ubiquitin carboxyl-terminal hydrolase
  6. XM_017000836.1XP_016856325.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X7

  7. XM_017000835.1XP_016856324.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

  8. XM_017000837.1XP_016856326.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X8

RNA

  1. XR_001737080.1 RNA Sequence

  2. XR_001737081.1 RNA Sequence

  3. XR_001737082.1 RNA Sequence

  4. XR_001737083.1 RNA Sequence

Support Center