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HAUS5 HAUS augmin like complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 23354, updated on 8-Jul-2021

Summary

Official Symbol
HAUS5provided by HGNC
Official Full Name
HAUS augmin like complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:29130
See related
Ensembl:ENSG00000249115 MIM:613432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dgt5; KIAA0841
Summary
HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Expression
Ubiquitous expression in testis (RPKM 4.9), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See HAUS5 in Genome Data Viewer
Location:
19q13.12
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35612735..35625355)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36103637..36116257)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene long intergenic non-protein coding RNA 1766 Neighboring gene tRNA-undetermined (NNN) 10-1 Neighboring gene Sharpr-MPRA regulatory region 5913 Neighboring gene RNA binding motif protein 42 Neighboring gene ETS variant transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitotic spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
HAUS augmin-like complex subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015302.2NP_056117.1  HAUS augmin-like complex subunit 5

    See identical proteins and their annotated locations for NP_056117.1

    Status: VALIDATED

    Source sequence(s)
    AB020648, AC002115, BC064390
    Consensus CDS
    CCDS42550.1
    UniProtKB/Swiss-Prot
    O94927
    Related
    ENSP00000439056.1, ENST00000203166.10
    Conserved Domains (1) summary
    pfam14817
    Location:7619
    HAUS5; HAUS augmin-like complex subunit 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35612735..35625355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526684.2XP_011524986.1  HAUS augmin-like complex subunit 5 isoform X1

    See identical proteins and their annotated locations for XP_011524986.1

    Conserved Domains (1) summary
    pfam14817
    Location:1519
    HAUS5; HAUS augmin-like complex subunit 5

RNA

  1. XR_001753641.1 RNA Sequence

    Related
    ENST00000424522.5
  2. XR_243915.3 RNA Sequence

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