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U2SURP U2 snRNP associated SURP domain containing [ Homo sapiens (human) ]

Gene ID: 23350, updated on 3-May-2020

Summary

Official Symbol
U2SURPprovided by HGNC
Official Full Name
U2 snRNP associated SURP domain containingprovided by HGNC
Primary source
HGNC:HGNC:30855
See related
Ensembl:ENSG00000163714 MIM:617849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR140; fSAPa
Expression
Ubiquitous expression in bone marrow (RPKM 18.6), lymph node (RPKM 15.0) and 25 other tissues See more
Orthologs

Genomic context

See U2SURP in Genome Data Viewer
Location:
3q23
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (143001570..143060725)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142720366..142779567)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 9 Neighboring gene PAQR9 antisense RNA 1 Neighboring gene uncharacterized LOC100289361 Neighboring gene uncharacterized LOC105374138 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4297 Neighboring gene carbohydrate sulfotransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of U2 snRNP-associated SURP domain containing (U2SURP) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0332, MGC133197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
U2 snRNP-associated SURP motif-containing protein
Names
140 kDa Ser/Arg-rich domain protein
Ser/Arg-rich domain protein, 140 kDa
U2-associated SR140 protein
U2-associated protein SR140
functional spliceosome-associated protein a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080415.2NP_001073884.1  U2 snRNP-associated SURP motif-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001073884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC018450, AC026304
    Consensus CDS
    CCDS46928.1
    UniProtKB/Swiss-Prot
    O15042
    Related
    ENSP00000418563.1, ENST00000473835.7
    Conserved Domains (5) summary
    smart00582
    Location:541676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156352
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:273356
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:428479
    Surp; Surp module
    pfam08312
    Location:845884
    cwf21; cwf21 domain
  2. NM_001320219.2NP_001307148.1  U2 snRNP-associated SURP motif-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC018450, BC006474, BC111692
    UniProtKB/Swiss-Prot
    O15042
    Related
    ENSP00000422011.1, ENST00000493598.6
    Conserved Domains (5) summary
    smart00582
    Location:540675
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156351
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:272355
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:427478
    Surp; Surp module
    pfam08312
    Location:844883
    cwf21; cwf21 domain
  3. NM_001320220.2NP_001307149.1  U2 snRNP-associated SURP motif-containing protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC018450, BC111692
    UniProtKB/Swiss-Prot
    O15042
    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:436475
    cwf21; cwf21 domain
  4. NM_001320222.2NP_001307151.1  U2 snRNP-associated SURP motif-containing protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC018450, BC028110, BC111692
    UniProtKB/Swiss-Prot
    O15042
    Conserved Domains (3) summary
    smart00582
    Location:108243
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:147
    Surp; Surp module
    pfam08312
    Location:410451
    cwf21; cwf21 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    143001570..143060725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247248.5XP_005247305.1  U2 snRNP-associated SURP motif-containing protein isoform X1

    See identical proteins and their annotated locations for XP_005247305.1

    Conserved Domains (5) summary
    smart00582
    Location:541676
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    COG0724
    Location:156352
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12223
    Location:273356
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:428479
    Surp; Surp module
    pfam08312
    Location:845884
    cwf21; cwf21 domain
  2. XM_017006038.1XP_016861527.1  U2 snRNP-associated SURP motif-containing protein isoform X3

    UniProtKB/Swiss-Prot
    O15042
    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:436475
    cwf21; cwf21 domain
  3. XM_024453425.1XP_024309193.1  U2 snRNP-associated SURP motif-containing protein isoform X2

    Conserved Domains (4) summary
    smart00582
    Location:296431
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    cd12223
    Location:28111
    RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
    pfam01805
    Location:185235
    Surp; Surp module
    pfam08312
    Location:598639
    cwf21; cwf21 domain
  4. XM_017006039.1XP_016861528.1  U2 snRNP-associated SURP motif-containing protein isoform X3

    UniProtKB/Swiss-Prot
    O15042
    Conserved Domains (3) summary
    smart00582
    Location:132267
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    pfam01805
    Location:1970
    Surp; Surp module
    pfam08312
    Location:436475
    cwf21; cwf21 domain
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