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FN1 fibronectin 1 [ Homo sapiens (human) ]

Gene ID: 2335, updated on 20-Jun-2021

Summary

Official Symbol
FN1provided by HGNC
Official Full Name
fibronectin 1provided by HGNC
Primary source
HGNC:HGNC:3778
See related
Ensembl:ENSG00000115414 MIM:135600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Expression
Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more
Orthologs
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Genomic context

See FN1 in Genome Data Viewer
Location:
2q35
Exon count:
46
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (215360862..215436167, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225588..216300791, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 31 Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene uncharacterized LOC112268430 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC105373868 Neighboring gene uncharacterized LOC102724849

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Glomerulopathy with fibronectin deposits 2
MedGen: C1866075 OMIM: 601894 GeneReviews: Not available
Compare labs
Spondylometaphyseal dysplasia - Sutcliffe type Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables collagen binding NAS
Non-traceable Author Statement
more info
PubMed 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables extracellular matrix structural constituent HDA PubMed 
enables extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proteoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in biological process involved in interaction with symbiont IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium-independent cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-substrate junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular protein metabolic process TAS
Traceable Author Statement
more info
 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in endodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extracellular matrix organization TAS
Traceable Author Statement
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration TAS
Traceable Author Statement
more info
 
involved_in negative regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration involved in autonomic nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in platelet degranulation TAS
Traceable Author Statement
more info
 
involved_in positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in post-translational protein modification TAS
Traceable Author Statement
more info
 
involved_in regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to wounding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in blood microparticle HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of fibrinogen complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fibronectin
Names
cold-insoluble globulin
epididymis secretory sperm binding protein
migration-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012196.1 RefSeqGene

    Range
    5001..80629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306129.2NP_001293058.2  fibronectin isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77526.1
    Related
    ENSP00000323534.6, ENST00000323926.10
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23542393
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  2. NM_001306130.2NP_001293059.2  fibronectin isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77525.1
    Related
    ENSP00000399538.2, ENST00000432072.6
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21752214
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  3. NM_001306131.2NP_001293060.2  fibronectin isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77523.1
    Related
    ENSP00000415018.1, ENST00000443816.5
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21732212
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  4. NM_001306132.2NP_001293061.2  fibronectin isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS77522.1
    Related
    ENSP00000394423.1, ENST00000421182.5
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21482187
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  5. NM_001365517.2NP_001352446.1  fibronectin isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22952334
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401619
    fn3; Fibronectin type III domain
  6. NM_001365518.2NP_001352447.1  fibronectin isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Related
    ENSP00000352696.1, ENST00000359671.5
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491528
    fn3; Fibronectin type III domain
  7. NM_001365519.2NP_001352448.1  fibronectin isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22702309
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401619
    fn3; Fibronectin type III domain
  8. NM_001365520.2NP_001352449.1  fibronectin isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22692308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491528
    fn3; Fibronectin type III domain
  9. NM_001365521.2NP_001352450.1  fibronectin isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401619
    fn3; Fibronectin type III domain
  10. NM_001365522.2NP_001352451.1  fibronectin isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22392278
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401619
    fn3; Fibronectin type III domain
  11. NM_001365523.2NP_001352452.1  fibronectin isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21792218
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491528
    fn3; Fibronectin type III domain
  12. NM_001365524.2NP_001352453.1  fibronectin isoform 19 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (5) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21742213
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491528
    fn3; Fibronectin type III domain
  13. NM_002026.4NP_002017.2  fibronectin isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS2399.1
    Related
    ENSP00000338200.4, ENST00000336916.8
  14. NM_054034.3NP_473375.2  fibronectin isoform 7 preproprotein

    See identical proteins and their annotated locations for NP_473375.2

    Status: REVIEWED

    Source sequence(s)
    AC012462
    Consensus CDS
    CCDS46512.1
    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000398907.1, ENST00000426059.1
    Conserved Domains (4) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:5289
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
  15. NM_212474.3NP_997639.2  fibronectin isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS2400.1
    Related
    ENSP00000350534.4, ENST00000357867.8
  16. NM_212476.3NP_997641.2  fibronectin isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS42813.1
    Related
    ENSP00000348285.4, ENST00000356005.8
  17. NM_212478.3NP_997643.2  fibronectin isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS46510.1
    Related
    ENSP00000410422.1, ENST00000446046.5
  18. NM_212482.4NP_997647.2  fibronectin isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Consensus CDS
    CCDS42814.1
    Related
    ENSP00000346839.4, ENST00000354785.11
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23852424
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    215360862..215436167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003692.1XP_016859181.1  fibronectin isoform X16

  2. XM_005246402.1XP_005246459.1  fibronectin isoform X6

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23292368
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  3. XM_024452769.1XP_024308537.1  fibronectin isoform X4

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23602399
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  4. XM_005246416.1XP_005246473.1  fibronectin isoform X24

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21482187
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  5. XM_017003695.1XP_016859184.1  fibronectin isoform X20

  6. XM_005246404.1XP_005246461.1  fibronectin isoform X8

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  7. XM_005246411.1XP_005246468.1  fibronectin isoform X21

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21752214
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  8. XM_005246410.1XP_005246467.1  fibronectin isoform X18

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22392278
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  9. XM_024452770.1XP_024308538.1  fibronectin isoform X11

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22702309
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  10. XM_005246408.1XP_005246465.1  fibronectin isoform X13

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  11. XM_005246403.1XP_005246460.1  fibronectin isoform X7

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22952334
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  12. XM_005246407.1XP_005246464.1  fibronectin isoform X12

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22652304
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  13. XM_005246401.1XP_005246458.1  fibronectin isoform X5

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23292368
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  14. XM_005246398.1XP_005246455.1  fibronectin isoform X2

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23602399
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  15. XM_005246399.1XP_005246456.1  fibronectin isoform X3

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23542393
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  16. XM_005246397.1XP_005246454.1  fibronectin isoform X1

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23852424
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212475.1: Suppressed sequence

    Description
    NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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