Format

Send to:

Choose Destination

FN1 fibronectin 1 [ Homo sapiens (human) ]

Gene ID: 2335, updated on 13-Jan-2019

Summary

Official Symbol
FN1provided by HGNC
Official Full Name
fibronectin 1provided by HGNC
Primary source
HGNC:HGNC:3778
See related
Ensembl:ENSG00000115414 MIM:135600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
Expression
Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more
Orthologs

Genomic context

See FN1 in Genome Data Viewer
Location:
2q35
Exon count:
46
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (215360440..215436167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225177..216300890, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928103 Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene uncharacterized LOC112268430 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC105373868 Neighboring gene uncharacterized LOC102724849

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glomerulopathy with fibronectin deposits 2
MedGen: C1866075 OMIM: 601894 GeneReviews: Not available
Compare labs
Plasma fibronectin deficiency
MedGen: C2675436 OMIM: 614101 GeneReviews: Not available
Compare labs
Spondylometaphyseal dysplasia - Sutcliffe type
MedGen: C0432221 OMIM: 184255 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
    ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
    Angiopoietin receptor Tie2-mediated signaling
  • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
    Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • DAP12 signaling, organism-specific biosystem (from REACTOME)
    DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
    FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • Fibronectin matrix formation, organism-specific biosystem (from REACTOME)
    Fibronectin matrix formation, organism-specific biosystemFibronectin (FN1) is found in the extracellular matrix (ECM) of all cells as linear and branched networks that surround and connect neighbouring cells (Singh et al. 2010). Prior to matrix formation F...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Frs2-mediated activation, organism-specific biosystem (from REACTOME)
    Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
  • GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    GRB2 events in EGFR signaling, organism-specific biosystemAutophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through i...
  • GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystem (from REACTOME)
    GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting Grb2 to the FADK1/SRC activation complex.
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
    Inflammatory Response Pathway, organism-specific biosystem
    Inflammatory Response Pathway
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
    Integrin alphaIIb beta3 signaling, organism-specific biosystemAt the sites of vascular injury bioactive molecules such as thrombin, ADP, collagen, fibrinogen and thrombospondin are generated, secreted or exposed. These stimuli activate platelets, converting the...
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
  • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
    Integrins in angiogenesis, organism-specific biosystem
    Integrins in angiogenesis
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • MAP2K and MAPK activation, organism-specific biosystem (from REACTOME)
    MAP2K and MAPK activation, organism-specific biosystemActivated RAF proteins are restricted substrate kinases whose primary downstream targets are the two MAP2K proteins, MAPK2K1 and MAP2K2 (also known as MEK1 and MEK2) (reviewed in Roskoski, 2010, Rosk...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
    MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Nanoparticle-mediated activation of receptor signaling, organism-specific biosystem (from WikiPathways)
    Nanoparticle-mediated activation of receptor signaling, organism-specific biosystemNanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as pro...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • Overview of nanoparticle effects, organism-specific biosystem (from WikiPathways)
    Overview of nanoparticle effects, organism-specific biosystemThis pathway is giving a summary of currently known nanoparticle effects on cells and organisms. Although there is currently no nanoparticle specific effect known, there is a cascade of effects trigg...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Paradoxical activation of RAF signaling by kinase inactive BRAF, organism-specific biosystem (from REACTOME)
    Paradoxical activation of RAF signaling by kinase inactive BRAF, organism-specific biosystemWhile BRAF-specific inhibitors inhibit MAPK/ERK activation in the presence of the BRAF V600E mutant, paradoxical activation of ERK signaling has been observed after treatment of cells with inhibitor ...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
    Platelet Aggregation (Plug Formation), organism-specific biosystemThe tethering of platelets to the site of vascular injury is the first step in the formation of a platelet thrombus. Firm adhesion of these tethered platelets, as well as the additional recruitment o...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
    Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
    RAF/MAP kinase cascade, organism-specific biosystemThe RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Bin...
  • RET signaling, organism-specific biosystem (from REACTOME)
    RET signaling, organism-specific biosystemThe RET proto-oncogene encodes a receptor tyrosine kinase expressed primarily in urogenital precursor cells, spermatogonocytes, dopaminergic neurons, motor neurons and neural crest progenitors and de...
  • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
    Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
  • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
  • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
    SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by RAS mutants, organism-specific biosystem (from REACTOME)
    Signaling by RAS mutants, organism-specific biosystemMembers of the RAS gene family were the first oncogenes to be identified, and mutations in RAS are present in ~20-30% of human cancers (reviewed in Prior et al, 2012). Mutations in the KRAS gene are ...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling by high-kinase activity BRAF mutants, organism-specific biosystem (from REACTOME)
    Signaling by high-kinase activity BRAF mutants, organism-specific biosystemBRAF is mutated in about 8% of human cancers, with high prevalence in hairy cell leukemia, melanoma, papillary thyroid and ovarian carcinomas, colorectal cancer and a variety of other tumors (Davies ...
  • Signaling by moderate kinase activity BRAF mutants, organism-specific biosystem (from REACTOME)
    Signaling by moderate kinase activity BRAF mutants, organism-specific biosystemIn addition to the highly prevalent and activating V600E BRAF mutations, numerous moderately activating and less common mutations have also been identified in human cancers (Forbes et al, 2015). Unl...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Signalling to ERKs, organism-specific biosystem (from REACTOME)
    Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
  • Signalling to RAS, organism-specific biosystem (from REACTOME)
    Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
  • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
    Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
  • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
    Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-2-mediated signaling events, organism-specific biosystem
    Syndecan-2-mediated signaling events
  • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Syndecan-4-mediated signaling events, organism-specific biosystem
    Syndecan-4-mediated signaling events
  • TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystem (from WikiPathways)
    TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, organism-specific biosystemThis pathway is based on the Figure 7 of "Cadherin 6 Is a New RUNX2 Target in TGF-? Signalling Pathway" (see bibliography). TGF-B is a target gene in thyroid cells in the causation of cancer. When TG...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
  • VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem (from Pathway Interaction Database)
    VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem
    VEGFR3 signaling in lymphatic endothelium
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling
  • miRNA targets in ECM and membrane receptors, organism-specific biosystem (from WikiPathways)
    miRNA targets in ECM and membrane receptors, organism-specific biosystemBased on the KEGG ECM-receptor interactions pathway (hsa04512), a depiction a plausible mechanism, where miRNAs regulate components of both extracellular matrix (top panel) and transmembrane receptor...
  • p130Cas linkage to MAPK signaling for integrins, organism-specific biosystem (from REACTOME)
    p130Cas linkage to MAPK signaling for integrins, organism-specific biosystemIntegrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
collagen binding NAS
Non-traceable Author Statement
more info
PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
extracellular matrix structural constituent HDA PubMed 
extracellular matrix structural constituent ISS
Inferred from Sequence or Structural Similarity
more info
 
heparin binding NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptidase activator activity IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
calcium-independent cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell-substrate junction assembly IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
interaction with other organism via secreted substance involved in symbiotic interaction IDA
Inferred from Direct Assay
more info
PubMed 
interaction with symbiont IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of transforming growth factor-beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
neural crest cell migration involved in autonomic nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding NAS
Non-traceable Author Statement
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibronectin
Names
cold-insoluble globulin
epididymis secretory sperm binding protein
migration-stimulating factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012196.1 RefSeqGene

    Range
    5001..80629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306129.1NP_001293058.1  fibronectin isoform 8 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 8 encoded by this variant is shorter than isoform 1. The encoded isoform (8) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BC143754, BX537590, BX640803, BX640875, CA422234, CR749316, CR749317, DA851446
    Consensus CDS
    CCDS77526.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000323534.6, ENST00000323926.10
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23542393
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  2. NM_001306130.1NP_001293059.1  fibronectin isoform 9 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. Isoform 9 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1. The encoded isoform (9) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BC143754, BX640803, BX640875, CA422234, CR749316, CR749317, DA851446
    Consensus CDS
    CCDS77525.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    B7ZLE5
    Related
    ENSP00000399538.2, ENST00000432072.6
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21752214
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  3. NM_001306131.1NP_001293060.1  fibronectin isoform 10 precursor

    See identical proteins and their annotated locations for NP_001293060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks two alternate in-frame exons in the central and 3' coding regions, and contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 10 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1. The encoded isoform (10) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, CR749281, CR749317, DA851446, U60068
    Consensus CDS
    CCDS77523.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZM7, Q9UQS6
    Related
    ENSP00000415018.1, ENST00000443816.5
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21732212
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  4. NM_001306132.1NP_001293061.1  fibronectin isoform 11 precursor

    See identical proteins and their annotated locations for NP_001293061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two alternate in-frame exons in the central and 3' coding regions, and contains a segment with an alternate splice structure in the 3' coding region, compared to variant 1. Isoform 11 encoded by this variant has a distinct internal amino acid and is shorter than isoform 1. The encoded isoform (11) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BC143754, BX640803, BX640875, CA422234, CR749317, DA851446, U60068
    Consensus CDS
    CCDS77522.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    B7ZLE5, Q9UQS6
    Related
    ENSP00000394423.1, ENST00000421182.5
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21482187
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  5. NM_001365517.1NP_001352446.1  fibronectin isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22952334
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  6. NM_001365518.1NP_001352447.1  fibronectin isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  7. NM_001365519.1NP_001352448.1  fibronectin isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22702309
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  8. NM_001365520.1NP_001352449.1  fibronectin isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22692308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  9. NM_001365521.1NP_001352450.1  fibronectin isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  10. NM_001365522.1NP_001352451.1  fibronectin isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22392278
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  11. NM_001365523.1NP_001352452.1  fibronectin isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21792218
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  12. NM_001365524.1NP_001352453.1  fibronectin isoform 19 precursor

    Status: REVIEWED

    Source sequence(s)
    AC012462, AC073284
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21742213
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  13. NM_002026.3NP_002017.1  fibronectin isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_002017.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and an internal segment in the coding region, as compared to variant 1. Isoform 3 encoded by this variant thus lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640638, BX640731, BX640802, CR749317, X02761
    Consensus CDS
    CCDS2399.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZF4, Q6N084
    Related
    ENSP00000338200.4, ENST00000336916.8
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22632302
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  14. NM_054034.2NP_473375.2  fibronectin isoform 7 preproprotein

    See identical proteins and their annotated locations for NP_473375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. Isoform 7 encoded by this variant is much shorter and has a distinct C-terminus, as compared isoform 1.
    Source sequence(s)
    AJ276395, AJ535086, BX640608, BX640999
    Consensus CDS
    CCDS46512.1
    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000398907.1, ENST00000426059.1
    Conserved Domains (4) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:5289
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
  15. NM_212474.2NP_997639.1  fibronectin isoform 6 precursor

    See identical proteins and their annotated locations for NP_997639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons and an in-frame segment in the coding region, as compared to variant 1. Isoform 6 encoded by this variant thus lacks three internal segments, as compared to isoform 1. The encoded isoform (6) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, AL832202, BQ005645, CR749317, U60068, X02761
    Consensus CDS
    CCDS2400.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q9UQS6
    Related
    ENSP00000350534.4, ENST00000357867.8
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:20842123
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  16. NM_212476.2NP_997641.1  fibronectin isoform 5 precursor

    See identical proteins and their annotated locations for NP_997641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, as compared to variant 1. Isoform 5 encoded by this variant thus lacks two internal segments, as compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640608, CR749317, U60068, X02761
    Consensus CDS
    CCDS42813.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q9UQS6
    Related
    ENSP00000348285.4, ENST00000356005.8
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22042243
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  17. NM_212478.2NP_997643.1  fibronectin isoform 4 precursor

    See identical proteins and their annotated locations for NP_997643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. Isoform 4 encoded by this variant thus lacks three internal segments, as compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640802, CR749317, U60068, X02761
    Consensus CDS
    CCDS46510.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZF4, Q9UQS6
    Related
    ENSP00000410422.1, ENST00000446046.5
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22382277
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  18. NM_212482.3NP_997647.1  fibronectin isoform 1 precursor

    See identical proteins and their annotated locations for NP_997647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). The encoded isoform (1) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, CR749317, U60068
    Consensus CDS
    CCDS42814.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZM7, Q9UQS6
    Related
    ENSP00000346839.4, ENST00000354785.8
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23852424
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    215360440..215436167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246412.1XP_005246469.1  fibronectin isoform X22

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21792218
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  2. XM_005246414.1XP_005246471.1  fibronectin isoform X23

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21742213
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  3. XM_005246409.1XP_005246466.1  fibronectin isoform X15

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22692308
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  4. XM_005246406.1XP_005246463.1  fibronectin isoform X10

    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000352696.1, ENST00000359671.5
    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  5. XM_017003694.1XP_016859183.1  fibronectin isoform X19

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22392278
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  6. XM_024452771.1XP_024308539.1  fibronectin isoform X14

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22702309
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  7. XM_017003693.1XP_016859182.1  fibronectin isoform X17

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  8. XM_005246405.1XP_005246462.1  fibronectin isoform X9

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22952334
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  9. XM_017003692.1XP_016859181.1  fibronectin isoform X16

  10. XM_005246402.1XP_005246459.1  fibronectin isoform X6

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23292368
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  11. XM_024452769.1XP_024308537.1  fibronectin isoform X4

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23602399
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  12. XM_005246416.1XP_005246473.1  fibronectin isoform X24

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21482187
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:18141894
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  13. XM_017003695.1XP_016859184.1  fibronectin isoform X20

  14. XM_005246404.1XP_005246461.1  fibronectin isoform X8

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22942333
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19041984
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:14491530
    fn3; Fibronectin type III domain
  15. XM_005246411.1XP_005246468.1  fibronectin isoform X21

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:21752214
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  16. XM_005246410.1XP_005246467.1  fibronectin isoform X18

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22392278
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  17. XM_024452770.1XP_024308538.1  fibronectin isoform X11

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22702309
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  18. XM_005246408.1XP_005246465.1  fibronectin isoform X13

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22642303
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  19. XM_005246403.1XP_005246460.1  fibronectin isoform X7

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22952334
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19051985
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  20. XM_005246407.1XP_005246464.1  fibronectin isoform X12

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:22652304
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  21. XM_005246401.1XP_005246458.1  fibronectin isoform X5

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23292368
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  22. XM_005246398.1XP_005246455.1  fibronectin isoform X2

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23602399
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  23. XM_005246399.1XP_005246456.1  fibronectin isoform X3

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23542393
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain
  24. XM_005246397.1XP_005246454.1  fibronectin isoform X1

    Conserved Domains (6) summary
    smart00059
    Location:353401
    FN2; Fibronectin type 2 domain
    smart00058
    Location:186230
    FN1; Fibronectin type 1 domain
    cd00061
    Location:23852424
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:19952075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:231270
    fn1; Fibronectin type I domain
    pfam00041
    Location:15401621
    fn3; Fibronectin type III domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212475.1: Suppressed sequence

    Description
    NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center