U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Crebzf CREB/ATF bZIP transcription factor [ Mus musculus (house mouse) ]

Gene ID: 233490, updated on 8-Dec-2022

Summary

Official Symbol
Crebzfprovided by MGI
Official Full Name
CREB/ATF bZIP transcription factorprovided by MGI
Primary source
MGI:MGI:2675296
See related
Ensembl:ENSMUSG00000051451 AllianceGenome:MGI:2675296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zf; LAZip; SMILE; LAZipII; 1110034C16Rik; 6330417B10Rik
Summary
Predicted to enable identical protein binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in regulation of transcription, DNA-templated and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Is expressed in eye; foot mesenchyme; and nervous system. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 27.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Crebzf in Genome Data Viewer
Location:
7; 7 E1
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (90091942..90097590)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (90442734..90448382)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 2 Neighboring gene coiled-coil domain containing 89 Neighboring gene transmembrane protein 126A Neighboring gene transmembrane protein 126B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CREB/ATF bZIP transcription factor
Names
HCF-binding transcription factor Zhangfei
host cell factor-binding transcription factor Zhangfei
tyrosine kinase-associated leucine zipper protein LAZip
tyrosine kinase-associated leucine zipper protein LAZipII

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145151.3NP_660133.2  CREB/ATF bZIP transcription factor

    See identical proteins and their annotated locations for NP_660133.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AC100322, AK004085
    Consensus CDS
    CCDS40020.1
    UniProtKB/Swiss-Prot
    Q91Y72, Q91ZR3
    Related
    ENSMUSP00000050972.6, ENSMUST00000061767.5
    Conserved Domains (1) summary
    cl21462
    Location:223264
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RNA

  1. NR_073436.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100322, AK004085, BI990274
  2. NR_073437.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100322, CX237465
  3. NR_073438.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA028814, AC100322, BG094109

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    90091942..90097590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507606.2XP_006507669.1  CREB/ATF bZIP transcription factor isoform X1

    See identical proteins and their annotated locations for XP_006507669.1

    UniProtKB/Swiss-Prot
    Q91Y72, Q91ZR3
    Conserved Domains (1) summary
    cl21462
    Location:223264
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain