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CLASP1 cytoplasmic linker associated protein 1 [ Homo sapiens (human) ]

Gene ID: 23332, updated on 8-Jan-2023

Summary

Official Symbol
CLASP1provided by HGNC
Official Full Name
cytoplasmic linker associated protein 1provided by HGNC
Primary source
HGNC:HGNC:17088
See related
Ensembl:ENSG00000074054 MIM:605852; AllianceGenome:HGNC:17088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAST1
Summary
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues See more
Orthologs
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Try the new Gene table
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Genomic context

See CLASP1 in Genome Data Viewer
Location:
2q14.2-q14.3
Exon count:
49
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (121337776..121649462, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (121773062..122084742, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (122095352..122407038, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor CP2 like 1 Neighboring gene ribosomal protein S17 pseudogene 7 Neighboring gene CLASP1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear Neighboring gene NIFK antisense RNA 1 Neighboring gene ribosomal protein L12 pseudogene 15 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2022-12-13)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2022-12-13)

ClinGen Genome Curation Page

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33821, FLJ41222, KIAA0622, MGC131895, DKFZp686D1968, DKFZp686H2039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dystroglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinetochore binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of epithelial cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of spindle orientation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of cell polarity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule depolymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vesicle targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosomal corona IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore microtubule TAS
Traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CLIP-associating protein 1
Names
multiple asters 1
multiple asters homolog 1
protein Orbit homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142273.2NP_001135745.1  CLIP-associating protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001135745.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate in-frame exons but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC132723, BE328429
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000389372.3, ENST00000455322.7
    Conserved Domains (4) summary
    PHA03307
    Location:565723
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
  2. NM_001142274.2NP_001135746.1  CLIP-associating protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001135746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate in-frame exon but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC112940, BE328429
    Consensus CDS
    CCDS92851.1
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000386442.3, ENST00000409078.8
    Conserved Domains (4) summary
    PHA03307
    Location:568715
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
  3. NM_001207051.2NP_001193980.1  CLIP-associating protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001193980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has several differences in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC144107, BE328429
    Consensus CDS
    CCDS92854.1
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000441625.1, ENST00000541377.5
    Conserved Domains (3) summary
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:324537
    CLASP_N; CLASP N terminal
  4. NM_001378003.1NP_001364932.1  CLIP-associating protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    Conserved Domains (4) summary
    PHA03307
    Location:568715
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:324537
    CLASP_N; CLASP N terminal
  5. NM_001378004.1NP_001364933.1  CLIP-associating protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    Conserved Domains (4) summary
    PHA03307
    Location:565723
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:324537
    CLASP_N; CLASP N terminal
  6. NM_001378005.1NP_001364934.1  CLIP-associating protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    Conserved Domains (3) summary
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:324537
    CLASP_N; CLASP N terminal
  7. NM_001395891.1NP_001382820.1  CLIP-associating protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
    Consensus CDS
    CCDS92853.1
    UniProtKB/TrEMBL
    A0A8V8TLP7
    Related
    ENSP00000512981.1, ENST00000696935.1
    Conserved Domains (2) summary
    PHA03307
    Location:564806
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  8. NM_015282.3NP_056097.1  CLIP-associating protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF347693, AJ288057, BC032563, BE328429
    Consensus CDS
    CCDS92852.1
    UniProtKB/Swiss-Prot
    Q7Z460, Q9BQT5
    Related
    ENSP00000263710.4, ENST00000263710.8
    Conserved Domains (3) summary
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    121337776..121649462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443792.1XP_047299748.1  CLIP-associating protein 1 isoform X22

    Related
    ENSP00000515167.1, ENST00000700755.1
  2. XM_047443782.1XP_047299738.1  CLIP-associating protein 1 isoform X7

  3. XM_006712383.2XP_006712446.1  CLIP-associating protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8V8TRF6
    Conserved Domains (4) summary
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam05956
    Location:566726
    APC_basic; APC basic domain
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
  4. XM_047443791.1XP_047299747.1  CLIP-associating protein 1 isoform X20

  5. XM_047443781.1XP_047299737.1  CLIP-associating protein 1 isoform X6

  6. XM_006712382.2XP_006712445.1  CLIP-associating protein 1 isoform X18

    Conserved Domains (4) summary
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam05956
    Location:566726
    APC_basic; APC basic domain
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
  7. XM_047443796.1XP_047299752.1  CLIP-associating protein 1 isoform X27

  8. XM_047443795.1XP_047299751.1  CLIP-associating protein 1 isoform X26

  9. XM_047443789.1XP_047299745.1  CLIP-associating protein 1 isoform X19

    Related
    ENSP00000515166.1, ENST00000700754.1
  10. XM_011510849.2XP_011509151.1  CLIP-associating protein 1 isoform X10

    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  11. XM_011510848.2XP_011509150.1  CLIP-associating protein 1 isoform X9

    UniProtKB/Swiss-Prot
    Q7Z460
    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  12. XM_047443786.1XP_047299742.1  CLIP-associating protein 1 isoform X14

  13. XM_047443788.1XP_047299744.1  CLIP-associating protein 1 isoform X17

  14. XM_047443778.1XP_047299734.1  CLIP-associating protein 1 isoform X3

  15. XM_017003673.2XP_016859162.1  CLIP-associating protein 1 isoform X12

    Conserved Domains (4) summary
    PHA03307
    Location:565723
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
  16. XM_047443784.1XP_047299740.1  CLIP-associating protein 1 isoform X11

  17. XM_047443787.1XP_047299743.1  CLIP-associating protein 1 isoform X16

  18. XM_006712381.2XP_006712444.1  CLIP-associating protein 1 isoform X15

    Conserved Domains (4) summary
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:168198
    HEAT; HEAT repeat
    pfam11179
    Location:572723
    DUF2967; Protein of unknown function (DUF2967)
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
  19. XM_047443783.1XP_047299739.1  CLIP-associating protein 1 isoform X8

  20. XM_047443785.1XP_047299741.1  CLIP-associating protein 1 isoform X13

  21. XM_047443797.1XP_047299753.1  CLIP-associating protein 1 isoform X28

  22. XM_047443780.1XP_047299736.1  CLIP-associating protein 1 isoform X5

  23. XM_047443779.1XP_047299735.1  CLIP-associating protein 1 isoform X4

  24. XM_017003665.2XP_016859154.1  CLIP-associating protein 1 isoform X2

  25. XM_047443777.1XP_047299733.1  CLIP-associating protein 1 isoform X1

  26. XM_047443793.1XP_047299749.1  CLIP-associating protein 1 isoform X22

  27. XM_017003682.3XP_016859171.1  CLIP-associating protein 1 isoform X23

    Related
    ENSP00000400562.3, ENST00000452274.7
    Conserved Domains (2) summary
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
    sd00044
    Location:604631
    HEAT; HEAT repeat [structural motif]
  28. XM_047443794.1XP_047299750.1  CLIP-associating protein 1 isoform X24

  29. XM_017003690.2XP_016859179.1  CLIP-associating protein 1 isoform X25

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    121773062..122084742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)