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CLASP1 cytoplasmic linker associated protein 1 [ Homo sapiens (human) ]

Gene ID: 23332, updated on 7-Jun-2020

Summary

Official Symbol
CLASP1provided by HGNC
Official Full Name
cytoplasmic linker associated protein 1provided by HGNC
Primary source
HGNC:HGNC:17088
See related
Ensembl:ENSG00000074054 MIM:605852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAST1
Summary
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See CLASP1 in Genome Data Viewer
Location:
2q14.2-q14.3
Exon count:
50
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (121337776..121649462, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (122095352..122407052, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor CP2 like 1 Neighboring gene ribosomal protein S17 pseudogene 7 Neighboring gene uncharacterized LOC107985942 Neighboring gene RNA, U4atac small nuclear (U12-dependent splicing) Neighboring gene NIFK antisense RNA 1 Neighboring gene ribosomal protein L12 pseudogene 15 Neighboring gene nucleophosmin 1 pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33821, FLJ41222, KIAA0622, MGC131895, DKFZp686D1968, DKFZp686H2039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dystroglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
establishment of epithelial cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of mitotic spindle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of spindle orientation IDA
Inferred from Direct Assay
more info
PubMed 
establishment of spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of spindle orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity NAS
Non-traceable Author Statement
more info
PubMed 
exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule organizing center organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of basement membrane assembly involved in embryonic body morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
centrosomal corona IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cortical microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore microtubule TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule plus-end ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CLIP-associating protein 1
Names
multiple asters 1
multiple asters homolog 1
protein Orbit homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142273.2NP_001135745.1  CLIP-associating protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001135745.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate in-frame exons but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC132723, BE328429
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000380717.4, ENST00000397587.7
    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  2. NM_001142274.2NP_001135746.1  CLIP-associating protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001135746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate in-frame exon but lacks two other alternate in-frame exons in the mid coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC112940, BE328429
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000386442.3, ENST00000409078.7
    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  3. NM_001207051.2NP_001193980.1  CLIP-associating protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001193980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has several differences in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AJ288057, BC032563, BC144107, BE328429
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000441625.1, ENST00000541377.5
    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  4. NM_001378003.1NP_001364932.1  CLIP-associating protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
  5. NM_001378004.1NP_001364933.1  CLIP-associating protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
  6. NM_001378005.1NP_001364934.1  CLIP-associating protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC012447, AC013399, AC018737, AC079449
  7. NM_015282.3NP_056097.1  CLIP-associating protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF347693, AJ288057, BC032563, BE328429
    UniProtKB/Swiss-Prot
    Q7Z460
    Related
    ENSP00000263710.4, ENST00000263710.8
    Conserved Domains (3) summary
    pfam05956
    Location:566778
    APC_basic; APC basic domain
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    121337776..121649462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712383.1XP_006712446.1  CLIP-associating protein 1 isoform X25

    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  2. XM_006712382.1XP_006712445.1  CLIP-associating protein 1 isoform X24

    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  3. XM_017003670.1XP_016859159.1  CLIP-associating protein 1 isoform X14

  4. XM_011510849.1XP_011509151.1  CLIP-associating protein 1 isoform X18

    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  5. XM_017003675.1XP_016859164.1  CLIP-associating protein 1 isoform X23

  6. XM_011510848.1XP_011509150.1  CLIP-associating protein 1 isoform X16

    UniProtKB/Swiss-Prot
    Q7Z460
    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  7. XM_017003669.1XP_016859158.1  CLIP-associating protein 1 isoform X13

  8. XM_017003674.1XP_016859163.1  CLIP-associating protein 1 isoform X21

  9. XM_017003673.1XP_016859162.1  CLIP-associating protein 1 isoform X20

  10. XM_017003667.1XP_016859156.1  CLIP-associating protein 1 isoform X11

  11. XM_006712381.1XP_006712444.1  CLIP-associating protein 1 isoform X22

    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  12. XM_017003672.1XP_016859161.1  CLIP-associating protein 1 isoform X19

  13. XM_006712377.1XP_006712440.1  CLIP-associating protein 1 isoform X17

    Conserved Domains (2) summary
    pfam12348
    Location:326537
    CLASP_N; CLASP N terminal
    sd00044
    Location:93120
    HEAT; HEAT repeat [structural motif]
  14. XM_017003657.1XP_016859146.1  CLIP-associating protein 1 isoform X1

  15. XM_017003665.1XP_016859154.1  CLIP-associating protein 1 isoform X9

  16. XM_006712385.1XP_006712448.1  CLIP-associating protein 1 isoform X31

    See identical proteins and their annotated locations for XP_006712448.1

    Related
    ENSP00000400562.3, ENST00000452274.6
    Conserved Domains (2) summary
    pfam12348
    Location:95306
    CLASP_N; CLASP N terminal
    sd00044
    Location:9981027
    HEAT; HEAT repeat [structural motif]
  17. XM_017003676.2XP_016859165.1  CLIP-associating protein 1 isoform X26

  18. XM_017003679.2XP_016859168.1  CLIP-associating protein 1 isoform X29

  19. XM_017003678.2XP_016859167.1  CLIP-associating protein 1 isoform X28

  20. XM_017003677.2XP_016859166.1  CLIP-associating protein 1 isoform X27

  21. XM_017003685.2XP_016859174.1  CLIP-associating protein 1 isoform X36

  22. XM_017003682.2XP_016859171.1  CLIP-associating protein 1 isoform X33

    Conserved Domains (2) summary
    pfam12348
    Location:94305
    CLASP_N; CLASP N terminal
    sd00044
    Location:604631
    HEAT; HEAT repeat [structural motif]
  23. XM_017003681.2XP_016859170.1  CLIP-associating protein 1 isoform X32

  24. XM_017003683.2XP_016859172.1  CLIP-associating protein 1 isoform X34

  25. XM_017003688.2XP_016859177.1  CLIP-associating protein 1 isoform X39

  26. XM_017003686.2XP_016859175.1  CLIP-associating protein 1 isoform X37

  27. XM_017003687.2XP_016859176.1  CLIP-associating protein 1 isoform X38

  28. XM_017003684.2XP_016859173.1  CLIP-associating protein 1 isoform X35

  29. XM_017003689.2XP_016859178.1  CLIP-associating protein 1 isoform X40

  30. XM_017003671.1XP_016859160.1  CLIP-associating protein 1 isoform X15

  31. XM_017003663.1XP_016859152.1  CLIP-associating protein 1 isoform X7

  32. XM_017003662.1XP_016859151.1  CLIP-associating protein 1 isoform X6

  33. XM_017003661.1XP_016859150.1  CLIP-associating protein 1 isoform X5

  34. XM_017003664.1XP_016859153.1  CLIP-associating protein 1 isoform X8

  35. XM_017003668.1XP_016859157.1  CLIP-associating protein 1 isoform X12

  36. XM_017003660.1XP_016859149.1  CLIP-associating protein 1 isoform X4

  37. XM_017003666.1XP_016859155.1  CLIP-associating protein 1 isoform X10

  38. XM_017003659.1XP_016859148.1  CLIP-associating protein 1 isoform X3

  39. XM_017003658.1XP_016859147.1  CLIP-associating protein 1 isoform X2

  40. XM_017003680.2XP_016859169.1  CLIP-associating protein 1 isoform X30

  41. XM_017003690.1XP_016859179.1  CLIP-associating protein 1 isoform X41

  42. XM_017003691.1XP_016859180.1  CLIP-associating protein 1 isoform X42

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