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TTC28 tetratricopeptide repeat domain 28 [ Homo sapiens (human) ]

Gene ID: 23331, updated on 23-Nov-2021

Summary

Official Symbol
TTC28provided by HGNC
Official Full Name
tetratricopeptide repeat domain 28provided by HGNC
Primary source
HGNC:HGNC:29179
See related
Ensembl:ENSG00000100154 MIM:615098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPRBK
Expression
Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.6) and 24 other tissues See more
Orthologs
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Genomic context

See TTC28 in Genome Data Viewer
Location:
22q12.1
Exon count:
29
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (27978014..28679865, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (28374002..29075853, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein beta Neighboring gene TTC28 antisense RNA 1 Neighboring gene microRNA 3199-1 Neighboring gene microRNA 3199-2 Neighboring gene RNA, 7SL, cytoplasmic 757, pseudogene Neighboring gene VISTA enhancer hs1645 Neighboring gene uncharacterized LOC101929594 Neighboring gene microRNA 5739 Neighboring gene Sharpr-MPRA regulatory region 11195 Neighboring gene RNA, 7SL, cytoplasmic 162, pseudogene Neighboring gene checkpoint kinase 2 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
A genome-wide association study on obesity and obesity-related traits.
GeneReviews: Not available
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of tetratricopeptide repeat domain 28 (TTC28) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1043

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 28
Names
TPR repeat protein 28
TPR repeat-containing big gene cloned at Keio
TPR-containing big gene cloned at Keio
NP_001138890.1
NP_001380332.1
NP_001380333.1
NP_001380334.1
XP_011528320.1
XP_011528321.1
XP_011528322.1
XP_011528323.1
XP_011528324.1
XP_016884162.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145418.2NP_001138890.1  tetratricopeptide repeat protein 28 isoform 1

    See identical proteins and their annotated locations for NP_001138890.1

    Status: VALIDATED

    Source sequence(s)
    AL023281, AL033538, AL035397, AL035453, AL050313, AL121825
    Consensus CDS
    CCDS46678.1
    UniProtKB/Swiss-Prot
    Q96AY4
    Related
    ENSP00000381003.2, ENST00000397906.6
    Conserved Domains (7) summary
    smart00028
    Location:394426
    TPR; Tetratricopeptide repeats
    COG0457
    Location:694995
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:91121
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:13901713
    CHAT; CHAT domain
    pfam13176
    Location:959994
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:94157
    TPR_11; TPR repeat
    pfam13424
    Location:315386
    TPR_12; Tetratricopeptide repeat
  2. NM_001393403.1NP_001380332.1  tetratricopeptide repeat protein 28 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL023281, AL033538, AL035397, AL035453, AL050313, AL121825
    Conserved Domains (5) summary
    TIGR02917
    Location:47937
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:91121
    TPR; TPR repeat [structural motif]
    pfam05109
    Location:20802328
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13424
    Location:9571029
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:13901713
    CHAT; CHAT domain
  3. NM_001393404.1NP_001380333.1  tetratricopeptide repeat protein 28 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL023281, AL033538, AL035397, AL035453, AL050313, AL080241
    Related
    ENSP00000479834.1, ENST00000612946.4
    Conserved Domains (5) summary
    COG0457
    Location:576877
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:476504
    TPR; TPR repeat [structural motif]
    pfam05109
    Location:19702218
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13424
    Location:239308
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:12721595
    CHAT; CHAT domain
  4. NM_001393405.1NP_001380334.1  tetratricopeptide repeat protein 28 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL023281, AL033538, AL035397, AL035453, AL050313, AL080241
    Conserved Domains (5) summary
    COG0457
    Location:576877
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:476504
    TPR; TPR repeat [structural motif]
    pfam05109
    Location:19622210
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13424
    Location:239308
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:12721595
    CHAT; CHAT domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    27978014..28679865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530018.3XP_011528320.1  tetratricopeptide repeat protein 28 isoform X2

    Conserved Domains (7) summary
    smart00028
    Location:368400
    TPR; Tetratricopeptide repeats
    COG0457
    Location:668969
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:6595
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:13641687
    CHAT; CHAT domain
    pfam13176
    Location:933968
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:68131
    TPR_11; TPR repeat
    pfam13424
    Location:289360
    TPR_12; Tetratricopeptide repeat
  2. XM_017028673.2XP_016884162.1  tetratricopeptide repeat protein 28 isoform X3

  3. XM_011530019.2XP_011528321.1  tetratricopeptide repeat protein 28 isoform X5

    Conserved Domains (5) summary
    COG0457
    Location:418717
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:91121
    TPR; TPR repeat [structural motif]
    pfam13176
    Location:959994
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:94157
    TPR_11; TPR repeat
    pfam13424
    Location:315386
    TPR_12; Tetratricopeptide repeat
  4. XM_011530021.3XP_011528323.1  tetratricopeptide repeat protein 28 isoform X8

    Conserved Domains (5) summary
    COG0457
    Location:698995
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:91121
    TPR; TPR repeat [structural motif]
    pfam13176
    Location:959994
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:593665
    TPR_11; TPR repeat
    pfam13424
    Location:515586
    TPR_12; Tetratricopeptide repeat
  5. XM_011530022.1XP_011528324.1  tetratricopeptide repeat protein 28 isoform X7

    Conserved Domains (5) summary
    COG0457
    Location:418717
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:91121
    TPR; TPR repeat [structural motif]
    pfam13176
    Location:959994
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:94157
    TPR_11; TPR repeat
    pfam13424
    Location:315386
    TPR_12; Tetratricopeptide repeat
  6. XM_011530020.1XP_011528322.1  tetratricopeptide repeat protein 28 isoform X6

    Conserved Domains (5) summary
    COG0457
    Location:698995
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:91121
    TPR; TPR repeat [structural motif]
    pfam13176
    Location:959994
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:593665
    TPR_11; TPR repeat
    pfam13424
    Location:515586
    TPR_12; Tetratricopeptide repeat

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015281.1: Suppressed sequence

    Description
    NM_015281.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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