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MAN2B2 mannosidase alpha class 2B member 2 [ Homo sapiens (human) ]

Gene ID: 23324, updated on 11-Jun-2021

Summary

Official Symbol
MAN2B2provided by HGNC
Official Full Name
mannosidase alpha class 2B member 2provided by HGNC
Primary source
HGNC:HGNC:29623
See related
Ensembl:ENSG00000013288 MIM:618899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 17.8), ovary (RPKM 16.8) and 25 other tissues See more
Orthologs
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Genomic context

See MAN2B2 in Genome Data Viewer
Location:
4p16.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (6575189..6623362)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6576916..6625089)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bgamma Neighboring gene uncharacterized LOC105374365 Neighboring gene Morf4 family associated protein 1 Neighboring gene long intergenic non-protein coding RNA 2482

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mannosidase, alpha, class 2B, member 2 (MAN2B2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Specific alterations of the N-linked carbohydrates on HIV-1 gp120 and gp41 by glucosidases and mannosidase inhibitors can enhance mannose-binding lectin (MBL)-mediated neutralization of virus by strengthening the interaction of HIV-1 with MBL PubMed
env HIV-1 gp120 N-linked oligosaccharides are processed by manosidase I and II in the Golgi complex PubMed
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in lysosomal lumen TAS
Traceable Author Statement
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
epididymis-specific alpha-mannosidase
Names
alpha-1,6-mannosidase
core-specific lysosomal alpha-1,6-Mannosidase
epididymis secretory sperm binding protein
NP_001278967.1
NP_056089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292038.2NP_001278967.1  epididymis-specific alpha-mannosidase isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC093323
    Consensus CDS
    CCDS77898.1
    UniProtKB/Swiss-Prot
    Q9Y2E5
    UniProtKB/TrEMBL
    B7Z754, E9PCD7
    Related
    ENSP00000423129.1, ENST00000504248.5
    Conserved Domains (3) summary
    smart00872
    Location:307388
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:530951
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    cl15692
    Location:27301
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily
  2. NM_015274.3NP_056089.1  epididymis-specific alpha-mannosidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_056089.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093323
    Consensus CDS
    CCDS33951.1
    UniProtKB/Swiss-Prot
    Q9Y2E5
    Related
    ENSP00000285599.3, ENST00000285599.8
    Conserved Domains (3) summary
    cd10811
    Location:27352
    GH38N_AMII_Epman_like; N-terminal catalytic domain of mammalian core-specific lysosomal alpha 1,6-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:358439
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:5811002
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    6575189..6623362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001741189.1 RNA Sequence

  2. XR_241647.4 RNA Sequence

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