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Tbc1d17 TBC1 domain family, member 17 [ Mus musculus (house mouse) ]

Gene ID: 233204, updated on 6-Jun-2024

Summary

Official Symbol
Tbc1d17provided by MGI
Official Full Name
TBC1 domain family, member 17provided by MGI
Primary source
MGI:MGI:2449973
See related
Ensembl:ENSMUSG00000038520 AllianceGenome:MGI:2449973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within autophagy and protein transport. Predicted to be located in cytosol. Is expressed in central nervous system and retina. Orthologous to human TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 47.1), ovary adult (RPKM 39.1) and 28 other tissues See more
Orthologs
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Genomic context

See Tbc1d17 in Genome Data Viewer
Location:
7 B3; 7 28.93 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44490200..44498314, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44840776..44849079, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene predicted gene, 29791 Neighboring gene STARR-seq mESC enhancer starr_18815 Neighboring gene STARR-seq mESC enhancer starr_18816 Neighboring gene STARR-positive B cell enhancer ABC_E1086 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62 Neighboring gene STARR-positive B cell enhancer ABC_E9111 Neighboring gene interleukin 4 induced 1 Neighboring gene AKT1 substrate 1 Neighboring gene microRNA 707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC27642

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TBC1 domain family member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042655.2NP_001036120.1  TBC1 domain family member 17 isoform 1

    See identical proteins and their annotated locations for NP_001036120.1

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Consensus CDS
    CCDS39944.1
    UniProtKB/Swiss-Prot
    Q3TCA5, Q8BYH7
    UniProtKB/TrEMBL
    Q3U5C0
    Related
    ENSMUSP00000048260.9, ENSMUST00000047085.16
    Conserved Domains (2) summary
    pfam12068
    Location:3217
    DUF3548; Domain of unknown function (DUF3548)
    smart00164
    Location:307542
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. NM_001420368.1NP_001407297.1  TBC1 domain family member 17 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    Q3U5C0
  3. NM_001420369.1NP_001407298.1  TBC1 domain family member 17 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    Q3U5C0
  4. NM_001420370.1NP_001407299.1  TBC1 domain family member 17 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    Q3U5C0
  5. NM_001420371.1NP_001407300.1  TBC1 domain family member 17 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    Q3U5C0
  6. NM_001420372.1NP_001407301.1  TBC1 domain family member 17 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    Q3U5C0

RNA

  1. NR_185164.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Related
    ENSMUST00000145959.8
  2. NR_185165.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158231
  3. NR_185166.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158231
  4. NR_185167.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158231
  5. NR_185168.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158231
  6. NR_185169.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158231

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44490200..44498314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144924.1: Suppressed sequence

    Description
    NM_144924.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.