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Ctu1 cytosolic thiouridylase subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 233189, updated on 25-May-2024

Summary

Official Symbol
Ctu1provided by MGI
Official Full Name
cytosolic thiouridylase subunit 1provided by MGI
Primary source
MGI:MGI:2385277
See related
Ensembl:ENSMUSG00000038888 AllianceGenome:MGI:2385277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpbd3
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 15.0), adrenal adult (RPKM 9.3) and 27 other tissues See more
Orthologs
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Genomic context

See Ctu1 in Genome Data Viewer
Location:
7 B3; 7 28.26 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43321400..43327724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43671971..43678301)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig-like lectin E Neighboring gene uncharacterized LOC118567526 Neighboring gene STARR-positive B cell enhancer ABC_E11351 Neighboring gene kallikrein related-peptidase 14 Neighboring gene kallikrein related-peptidase 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC6894

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of cytosolic tRNA wobble base thiouridylase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
cytoplasmic tRNA 2-thiolation protein 1
Names
ATP binding domain 3
ATP-binding domain-containing protein 3
cytoplasmic tRNA adenylyltransferase 1
cytosolic thiouridylase subunit 1 homolog
NP_663557.1
XP_017177659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145582.1NP_663557.1  cytoplasmic tRNA 2-thiolation protein 1

    See identical proteins and their annotated locations for NP_663557.1

    Status: PROVISIONAL

    Source sequence(s)
    BC005752
    Consensus CDS
    CCDS21179.1
    UniProtKB/Swiss-Prot
    Q99J10
    Related
    ENSMUSP00000036770.9, ENSMUST00000038332.9
    Conserved Domains (3) summary
    TIGR00269
    Location:207308
    TIGR00269; TIGR00269 family protein
    COG0037
    Location:54329
    TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]
    cd01993
    Location:54243
    Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43321400..43327724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322170.3XP_017177659.1  cytoplasmic tRNA 2-thiolation protein 1 isoform X1

    Conserved Domains (2) summary
    cd01993
    Location:54243
    Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
    cl25646
    Location:207308
    zn-ribbon_14; Zinc-ribbon