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SLC9A8 solute carrier family 9 member A8 [ Homo sapiens (human) ]

Gene ID: 23315, updated on 1-Aug-2020

Summary

Official Symbol
SLC9A8provided by HGNC
Official Full Name
solute carrier family 9 member A8provided by HGNC
Primary source
HGNC:HGNC:20728
See related
Ensembl:ENSG00000197818 MIM:612730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHE8; NHE-8
Summary
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 8.0), testis (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See SLC9A8 in Genome Data Viewer
Location:
20q13.13
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49812713..49892242)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48429250..48508779)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372652 Neighboring gene RNA, U6 small nuclear 919, pseudogene Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) pseudogene Neighboring gene RNA, U7 small nuclear 72 pseudogene Neighboring gene microRNA 12122 Neighboring gene uncharacterized LOC105372653 Neighboring gene spermatogenesis associated 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42500, KIAA0939, MGC138418, DKFZp686C03237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 8
Names
Na(+)/H(+) exchanger 8
solute carrier family 9 (sodium/hydrogen exchanger), isoform 8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260491.1NP_001247420.1  sodium/hydrogen exchanger 8 isoform 1

    See identical proteins and their annotated locations for NP_001247420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB023156, AK295822, AK300318, AL049469, AL162615
    Consensus CDS
    CCDS58774.1
    UniProtKB/Swiss-Prot
    Q9Y2E8
    UniProtKB/TrEMBL
    B4DIX7
    Related
    ENSP00000416418.1, ENST00000417961.5
    Conserved Domains (1) summary
    COG0025
    Location:60500
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  2. NM_015266.3NP_056081.1  sodium/hydrogen exchanger 8 isoform 2

    See identical proteins and their annotated locations for NP_056081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB023156, AL031685, AL049469, AL162615
    Consensus CDS
    CCDS13421.1
    UniProtKB/Swiss-Prot
    Q9Y2E8
    Related
    ENSP00000354966.2, ENST00000361573.2
    Conserved Domains (1) summary
    cl25615
    Location:64542
    NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]

RNA

  1. NR_048537.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB023156, AK295822, AL049469, AL162615
  2. NR_048538.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB023156, AK295665, AK295822, AL049469, AL162615
  3. NR_048539.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB023156, AK295803, AK295822, AL049469, AL162615
  4. NR_048540.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks four internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB023156, AK308328, AL049469, AL162615

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49812713..49892242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528736.2XP_011527038.1  sodium/hydrogen exchanger 8 isoform X1

    Conserved Domains (1) summary
    COG0025
    Location:60533
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  2. XM_011528738.2XP_011527040.1  sodium/hydrogen exchanger 8 isoform X4

    Conserved Domains (1) summary
    cl01133
    Location:60494
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  3. XM_011528739.2XP_011527041.1  sodium/hydrogen exchanger 8 isoform X5

    Conserved Domains (1) summary
    COG0025
    Location:60492
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  4. XM_011528741.2XP_011527043.1  sodium/hydrogen exchanger 8 isoform X8

    Conserved Domains (1) summary
    COG0025
    Location:60461
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  5. XM_011528740.2XP_011527042.1  sodium/hydrogen exchanger 8 isoform X7

    Conserved Domains (1) summary
    COG0025
    Location:60533
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  6. XM_017027754.2XP_016883243.1  sodium/hydrogen exchanger 8 isoform X6

  7. XM_011528745.2XP_011527047.1  sodium/hydrogen exchanger 8 isoform X12

    Conserved Domains (1) summary
    cl01133
    Location:60253
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  8. XM_006723756.1XP_006723819.1  sodium/hydrogen exchanger 8 isoform X2

    Conserved Domains (1) summary
    COG0025
    Location:60517
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  9. XM_011528737.1XP_011527039.1  sodium/hydrogen exchanger 8 isoform X3

    Conserved Domains (1) summary
    COG0025
    Location:62505
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
  10. XM_017027755.2XP_016883244.1  sodium/hydrogen exchanger 8 isoform X9

    Conserved Domains (1) summary
    cl01133
    Location:1298
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  11. XM_011528742.1XP_011527044.1  sodium/hydrogen exchanger 8 isoform X9

    Conserved Domains (1) summary
    cl01133
    Location:1298
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  12. XM_017027756.2XP_016883245.1  sodium/hydrogen exchanger 8 isoform X10

    Conserved Domains (1) summary
    cl01133
    Location:5237
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  13. XM_011528743.2XP_011527045.1  sodium/hydrogen exchanger 8 isoform X10

    Conserved Domains (1) summary
    cl01133
    Location:5237
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  14. XM_011528744.2XP_011527046.1  sodium/hydrogen exchanger 8 isoform X11

    Conserved Domains (1) summary
    cl01133
    Location:3207
    Na_H_Exchanger; Sodium/hydrogen exchanger family
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