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SIN3B SIN3 transcription regulator family member B [ Homo sapiens (human) ]

Gene ID: 23309, updated on 6-Jan-2019

Summary

Official Symbol
SIN3Bprovided by HGNC
Official Full Name
SIN3 transcription regulator family member Bprovided by HGNC
Primary source
HGNC:HGNC:19354
See related
Ensembl:ENSG00000127511 MIM:607777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 19.2), endometrium (RPKM 17.1) and 25 other tissues See more
Orthologs

Genomic context

See SIN3B in Genome Data Viewer
Location:
19p13.11
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (16829387..16880355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16940209..16991166)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 38A Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 835, pseudogene Neighboring gene C3 and PZP like alpha-2-macroglobulin domain containing 8 Neighboring gene F2R like thrombin or trypsin receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0700

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Sin3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
X chromosome IEA
Inferred from Electronic Annotation
more info
 
XY body IEA
Inferred from Electronic Annotation
more info
 
Y chromosome IEA
Inferred from Electronic Annotation
more info
 
autosome IEA
Inferred from Electronic Annotation
more info
 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
paired amphipathic helix protein Sin3b
Names
SIN3 homolog B, transcriptional regulator
SIN3 transcription regulator homolog B
histone deacetylase complex subunit Sin3b
transcriptional corepressor Sin3b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297595.1NP_001284524.1  paired amphipathic helix protein Sin3b isoform 2

    See identical proteins and their annotated locations for NP_001284524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AB014600, AY706204, HY055983
    Consensus CDS
    CCDS74308.1
    UniProtKB/Swiss-Prot
    O75182
    Related
    ENSP00000248054.4, ENST00000248054.9
    Conserved Domains (3) summary
    pfam02671
    Location:60104
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:395489
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:7431043
    Sin3a_C; C-terminal domain of Sin3a protein
  2. NM_001297597.1NP_001284526.1  paired amphipathic helix protein Sin3b isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB014600, AK295618, AY706204, DC332740
    Consensus CDS
    CCDS77254.1
    UniProtKB/Swiss-Prot
    O75182
    UniProtKB/TrEMBL
    B7Z392, M0QYC5
    Related
    ENSP00000469740.1, ENST00000595541.1
    Conserved Domains (2) summary
    pfam08295
    Location:1279
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:333633
    Sin3a_C; C-terminal domain of Sin3a protein
  3. NM_015260.3NP_056075.1  paired amphipathic helix protein Sin3b isoform 1

    See identical proteins and their annotated locations for NP_056075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AY706204, HY055983
    Consensus CDS
    CCDS32946.1
    UniProtKB/Swiss-Prot
    O75182
    Related
    ENSP00000369131.1, ENST00000379803.5
    Conserved Domains (3) summary
    pfam02671
    Location:60104
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:395521
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:7751075
    Sin3a_C; C-terminal domain of Sin3a protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    16829387..16880355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722704.1XP_006722767.1  paired amphipathic helix protein Sin3b isoform X1

    Conserved Domains (1) summary
    pfam16879
    Location:258558
    Sin3a_C; C-terminal domain of Sin3a protein
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