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ICOSLG inducible T cell costimulator ligand [ Homo sapiens (human) ]

Gene ID: 23308, updated on 11-Sep-2019

Summary

Official Symbol
ICOSLGprovided by HGNC
Official Full Name
inducible T cell costimulator ligandprovided by HGNC
Primary source
HGNC:HGNC:17087
See related
Ensembl:ENSG00000160223 MIM:605717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7h; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Expression
Ubiquitous expression in brain (RPKM 4.2), lymph node (RPKM 3.4) and 23 other tissues See more
Orthologs

Genomic context

See ICOSLG in Genome Data Viewer
Location:
21q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (44216979..44240943, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45642874..45660881, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377139 Neighboring gene uncharacterized LOC107983952 Neighboring gene uncharacterized LOC102725065 Neighboring gene DNMT3L antisense RNA 1 Neighboring gene DNA methyltransferase 3 like Neighboring gene autoimmune regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
    Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0653

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell activation IEA
Inferred from Electronic Annotation
more info
 
T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
defense response NAS
Non-traceable Author Statement
more info
PubMed 
hyperosmotic response NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of activated T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ICOS ligand
Names
B7 homolog 2
B7 homologue 2
B7-like protein Gl50
B7-related protein 1
transmembrane protein B7-H2 ICOS ligand

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283050.2NP_001269979.1  ICOS ligand isoform b precursor

    See identical proteins and their annotated locations for NP_001269979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a.
    Source sequence(s)
    AA781960, AF199028, DC365972
    Consensus CDS
    CCDS63379.1
    UniProtKB/Swiss-Prot
    O75144
    Related
    ENSP00000339477.4, ENST00000344330.8
    Conserved Domains (2) summary
    pfam07686
    Location:20131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153225
    Ig; Immunoglobulin domain
  2. NM_001283051.2NP_001269980.1  ICOS ligand isoform c precursor

    See identical proteins and their annotated locations for NP_001269980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK090492, AP001058, BQ005303
    Consensus CDS
    CCDS63377.1
    UniProtKB/Swiss-Prot
    O75144
    Related
    ENSP00000383228.3, ENST00000400377.3
    Conserved Domains (1) summary
    cl11960
    Location:36108
    Ig; Immunoglobulin domain
  3. NM_001283052.2NP_001269981.1  ICOS ligand isoform d

    See identical proteins and their annotated locations for NP_001269981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, resulting in translation initiation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK294031, AP001058, BQ005303
    UniProtKB/TrEMBL
    B7Z1W8
    Conserved Domains (1) summary
    cl11960
    Location:68140
    Ig; Immunoglobulin domain
  4. NM_001365759.2NP_001352688.1  ICOS ligand isoform e

    Status: VALIDATED

    Source sequence(s)
    AP001058, AP001059
    Conserved Domains (1) summary
    cl11960
    Location:2104
    Ig; Immunoglobulin domain
  5. NM_015259.6NP_056074.1  ICOS ligand isoform a precursor

    See identical proteins and their annotated locations for NP_056074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AK314369, AP001058, BQ005303
    Consensus CDS
    CCDS42952.1
    UniProtKB/Swiss-Prot
    O75144
    UniProtKB/TrEMBL
    A0N0L8
    Related
    ENSP00000384432.3, ENST00000407780.7
    Conserved Domains (2) summary
    pfam07686
    Location:20131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153212
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    44216979..44240943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529516.3XP_011527818.1  ICOS ligand isoform X4

    See identical proteins and their annotated locations for XP_011527818.1

    Conserved Domains (1) summary
    cl11960
    Location:2104
    Ig; Immunoglobulin domain
  2. XM_011529514.3XP_011527816.1  ICOS ligand isoform X2

    See identical proteins and their annotated locations for XP_011527816.1

    Conserved Domains (2) summary
    pfam07686
    Location:20131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153225
    Ig; Immunoglobulin domain
  3. XM_011529515.3XP_011527817.1  ICOS ligand isoform X3

    See identical proteins and their annotated locations for XP_011527817.1

    Conserved Domains (2) summary
    pfam07686
    Location:20131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153225
    Ig; Immunoglobulin domain
  4. XM_024452060.1XP_024307828.1  ICOS ligand isoform X1

    Related
    ENSP00000383230.3, ENST00000400379.7
    Conserved Domains (2) summary
    pfam07686
    Location:20131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153212
    Ig; Immunoglobulin domain
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