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Ffar2 free fatty acid receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 233079, updated on 8-Feb-2024

Summary

Official Symbol
Ffar2provided by MGI
Official Full Name
free fatty acid receptor 2provided by MGI
Primary source
MGI:MGI:2441731
See related
Ensembl:ENSMUSG00000051314 AllianceGenome:MGI:2441731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr43; GPCR43
Summary
Enables G protein-coupled receptor activity. Involved in several processes, including leukocyte chemotaxis involved in inflammatory response; positive regulation of acute inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Predicted to be located in cell projection and plasma membrane. Is expressed in pancreas; pancreas epithelium; superior cervical ganglion; and testis. Orthologous to human FFAR2 (free fatty acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 10.2), subcutaneous fat pad adult (RPKM 8.2) and 10 other tissues See more
Orthologs
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Genomic context

See Ffar2 in Genome Data Viewer
Location:
7 B1; 7 19.25 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30517778..30523200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30818031..30823775, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dermokine Neighboring gene STARR-seq mESC enhancer starr_18532 Neighboring gene keratinocyte differentiation associated protein Neighboring gene predicted gene, 32236 Neighboring gene STARR-seq mESC enhancer starr_18534 Neighboring gene STARR-seq mESC enhancer starr_18536 Neighboring gene STARR-positive B cell enhancer ABC_E8162 Neighboring gene free fatty acid receptor 3 Neighboring gene free fatty acid receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC28611

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fatty acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte chemotaxis involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ligand-gated ion channel signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of peptide hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
free fatty acid receptor 2
Names
G protein-coupled receptor 43
leukocyte-specific STAT-induced GPCR

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168509.1NP_001161981.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_001161981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AI607149, AK078861
    Consensus CDS
    CCDS21111.1
    UniProtKB/Swiss-Prot
    Q8VCK6
    Related
    ENSMUSP00000129398.2, ENSMUST00000168528.8
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001168510.1NP_001161982.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_001161982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AI573563, AK078861
    Consensus CDS
    CCDS21111.1
    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001168511.1NP_001161983.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_001161983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK078861, CX231878
    Consensus CDS
    CCDS21111.1
    UniProtKB/Swiss-Prot
    Q8VCK6
    Related
    ENSMUSP00000127758.2, ENSMUST00000163504.8
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001168512.1NP_001161984.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_001161984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC165340, AK078861, CX228700
    Consensus CDS
    CCDS21111.1
    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_146187.4NP_666299.1  free fatty acid receptor 2

    See identical proteins and their annotated locations for NP_666299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AK078861
    Consensus CDS
    CCDS21111.1
    UniProtKB/Swiss-Prot
    Q8VCK6
    Related
    ENSMUSP00000052600.4, ENSMUST00000053156.10
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30517778..30523200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250554.4XP_011248856.1  free fatty acid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011248856.1

    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011250549.4XP_011248851.1  free fatty acid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011248851.1

    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_011250548.4XP_011248850.1  free fatty acid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011248850.1

    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011250553.3XP_011248855.1  free fatty acid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011248855.1

    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011250552.3XP_011248854.1  free fatty acid receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011248854.1

    UniProtKB/Swiss-Prot
    Q8VCK6
    Conserved Domains (1) summary
    cd15170
    Location:9286
    7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors