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Wdr62 WD repeat domain 62 [ Mus musculus (house mouse) ]

Gene ID: 233064, updated on 6-Jun-2024

Summary

Official Symbol
Wdr62provided by MGI
Official Full Name
WD repeat domain 62provided by MGI
Primary source
MGI:MGI:1923696
See related
Ensembl:ENSMUSG00000037020 AllianceGenome:MGI:1923696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b1508Clo; 2310038K02Rik
Summary
Predicted to be involved in several processes, including microtubule cytoskeleton organization; nervous system development; and positive regulation of neuron migration. Predicted to act upstream of or within neuronal stem cell population maintenance. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in nucleus and spindle pole. Is expressed in several structures, including brain; future brain; limb bud; nasal process; and trunk somite. Used to study primary autosomal recessive microcephaly 2 with or without cortical malformations. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 134.7) and placenta adult (RPKM 7.0) See more
Orthologs
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Genomic context

See Wdr62 in Genome Data Viewer
Location:
7 B1; 7 17.34 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29939563..29980243, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30240138..30281908, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene tubulin folding cofactor B Neighboring gene polymerase (RNA) II (DNA directed) polypeptide I Neighboring gene ovo like zinc finger 3 Neighboring gene ribosomal protein S12, pseudogene 5 Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:31065285-31065586 Neighboring gene THAP domain containing 8, pseudogene Neighboring gene CAP-GLY domain containing linker protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC31423

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat-containing protein 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408660.1NP_001395589.1  WD repeat-containing protein 62 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  2. NM_001408661.1NP_001395590.1  WD repeat-containing protein 62 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  3. NM_001408662.1NP_001395591.1  WD repeat-containing protein 62 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  4. NM_001408663.1NP_001395592.1  WD repeat-containing protein 62 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  5. NM_001408664.1NP_001395593.1  WD repeat-containing protein 62 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  6. NM_001408665.1NP_001395594.1  WD repeat-containing protein 62 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  7. NM_001408666.1NP_001395595.1  WD repeat-containing protein 62 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/TrEMBL
    E9QK36
  8. NM_001408667.1NP_001395596.1  WD repeat-containing protein 62 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  9. NM_001408668.1NP_001395597.1  WD repeat-containing protein 62 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC149067
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
  10. NM_146186.4NP_666298.4  WD repeat-containing protein 62 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149067, CD350442
    Consensus CDS
    CCDS52178.1
    UniProtKB/Swiss-Prot
    Q3U3T8, Q6PGG0, Q7TQE9
    UniProtKB/TrEMBL
    E9QK36
    Related
    ENSMUSP00000103825.2, ENSMUST00000108190.8
    Conserved Domains (3) summary
    sd00039
    Location:537578
    7WD40; WD40 repeat [structural motif]
    pfam15449
    Location:11171403
    Retinal; Retinal protein
    cl29593
    Location:364742
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_152437.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149067
    Related
    ENSMUST00000145027.8
  2. NR_176792.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC149067

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29939563..29980243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250545.4XP_011248847.1  WD repeat-containing protein 62 isoform X10

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (3) summary
    PHA03247
    Location:10051511
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011250543.4XP_011248845.1  WD repeat-containing protein 62 isoform X8

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (3) summary
    PHA03247
    Location:10091515
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011250541.4XP_011248843.1  WD repeat-containing protein 62 isoform X2

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (2) summary
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_006539877.5XP_006539940.1  WD repeat-containing protein 62 isoform X6

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (2) summary
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_011250544.4XP_011248846.1  WD repeat-containing protein 62 isoform X9

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (2) summary
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_011250542.4XP_011248844.1  WD repeat-containing protein 62 isoform X3

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (2) summary
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_011250540.4XP_011248842.1  WD repeat-containing protein 62 isoform X1

    UniProtKB/TrEMBL
    E9QK36
    Conserved Domains (3) summary
    PHA03247
    Location:10271533
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:538579
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:365743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_030242457.1XP_030098317.1  WD repeat-containing protein 62 isoform X15

    UniProtKB/TrEMBL
    F6R9F0
    Related
    ENSMUSP00000116139.2, ENSMUST00000134570.8
    Conserved Domains (2) summary
    sd00039
    Location:1044
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:4256
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004934072.1 RNA Sequence

  2. XR_391062.5 RNA Sequence

  3. XR_391064.5 RNA Sequence