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NEMP1 nuclear envelope integral membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 23306, updated on 5-Aug-2018

Summary

Official Symbol
NEMP1provided by HGNC
Official Full Name
nuclear envelope integral membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:29001
See related
Ensembl:ENSG00000166881 MIM:616496; Vega:OTTHUMG00000171021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM194; TMEM194A
Expression
Ubiquitous expression in lymph node (RPKM 5.8), testis (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See NEMP1 in Genome Data Viewer
Location:
12q13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (57055643..57088703, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57449426..57472574, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tachykinin 3 Neighboring gene myosin IA Neighboring gene NGFI-A binding protein 2 Neighboring gene signal transducer and activator of transcription 6 Neighboring gene LDL receptor related protein 1 Neighboring gene LRP1 antisense RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0286, DKFZp686N1768

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear envelope integral membrane protein 1
Names
transmembrane protein 194
transmembrane protein 194A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130963.1NP_001124435.1  nuclear envelope integral membrane protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001124435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB006624, AL833310, BQ001525, DB123768
    Consensus CDS
    CCDS44927.1
    UniProtKB/Swiss-Prot
    O14524
    Related
    ENSP00000300128.4, OTTHUMP00000244906, ENST00000300128.8, OTTHUMT00000411272
    Conserved Domains (1) summary
    pfam10225
    Location:154398
    DUF2215; Uncharacterized conserved protein (DUF2215)
  2. NM_015257.2NP_056072.2  nuclear envelope integral membrane protein 1 isoform b

    See identical proteins and their annotated locations for NP_056072.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB006624, AL833310, BC126300, BQ001525, DA724501
    Consensus CDS
    CCDS31841.1
    UniProtKB/Swiss-Prot
    O14524
    Related
    ENSP00000368701.3, OTTHUMP00000244905, ENST00000379391.7, OTTHUMT00000411271
    Conserved Domains (1) summary
    pfam10225
    Location:109325
    NEMP; NEMP family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    57055643..57088703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538056.2XP_011536358.1  nuclear envelope integral membrane protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10225
    Location:202446
    DUF2215; Uncharacterized conserved protein (DUF2215)
  2. XM_011538058.3XP_011536360.1  nuclear envelope integral membrane protein 1 isoform X3

    Conserved Domains (1) summary
    pfam10225
    Location:157373
    DUF2215; Uncharacterized conserved protein (DUF2215)
  3. XM_017019078.1XP_016874567.1  nuclear envelope integral membrane protein 1 isoform X4

    Conserved Domains (1) summary
    pfam10225
    Location:1227
    DUF2215; Uncharacterized conserved protein (DUF2215)
  4. XM_011538057.2XP_011536359.1  nuclear envelope integral membrane protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10225
    Location:162406
    NEMP; NEMP family
  5. XM_024448900.1XP_024304668.1  nuclear envelope integral membrane protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10225
    Location:162406
    NEMP; NEMP family
  6. XM_011538059.1XP_011536361.1  nuclear envelope integral membrane protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011536361.1

    Conserved Domains (1) summary
    pfam10225
    Location:1227
    DUF2215; Uncharacterized conserved protein (DUF2215)
  7. XM_017019079.1XP_016874568.1  nuclear envelope integral membrane protein 1 isoform X6

    Conserved Domains (1) summary
    pfam10225
    Location:1207
    DUF2215; Uncharacterized conserved protein (DUF2215)
  8. XM_011538060.2XP_011536362.1  nuclear envelope integral membrane protein 1 isoform X5

    Conserved Domains (1) summary
    pfam10225
    Location:202261
    DUF2215; Uncharacterized conserved protein (DUF2215)
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