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WSCD1 WSC domain containing 1 [ Homo sapiens (human) ]

Gene ID: 23302, updated on 22-Sep-2022

Summary

Official Symbol
WSCD1provided by HGNC
Official Full Name
WSC domain containing 1provided by HGNC
Primary source
HGNC:HGNC:29060
See related
Ensembl:ENSG00000179314 MIM:619584; AllianceGenome:HGNC:29060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable sulfotransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 6.9), spleen (RPKM 4.6) and 14 other tissues See more
Orthologs
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Genomic context

See WSCD1 in Genome Data Viewer
Location:
17p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6069116..6124427)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (5963314..6018611)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (5972436..6027747)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 1 (C. elegans) pseudogene Neighboring gene uncharacterized LOC339166 Neighboring gene uncharacterized LOC105371508 Neighboring gene Sharpr-MPRA regulatory region 13257

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WSC domain containing 1 (WSCD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • KIAA0523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WSC domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388405.1NP_001375334.1  WSC domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770
    UniProtKB/Swiss-Prot
    Q96G45
    Related
    ENSP00000460825.1, ENST00000574946.5
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:425517
    Sulfotransfer_3; Sulfotransferase family
  2. NM_001388406.1NP_001375335.1  WSC domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770
    UniProtKB/Swiss-Prot
    Q96G45
    Related
    ENSP00000458374.1, ENST00000574232.5
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:425517
    Sulfotransfer_3; Sulfotransferase family
  3. NM_001388407.1NP_001375336.1  WSC domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770
    UniProtKB/Swiss-Prot
    Q96G45
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:425517
    Sulfotransfer_3; Sulfotransferase family
  4. NM_001388408.1NP_001375337.1  WSC domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770
    Related
    ENSP00000460396.1, ENST00000573634.5
    Conserved Domains (2) summary
    smart00321
    Location:77172
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:257349
    Sulfotransfer_3; Sulfotransferase family
  5. NM_001388409.1NP_001375338.1  WSC domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770
    Conserved Domains (2) summary
    smart00321
    Location:77172
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:257349
    Sulfotransfer_3; Sulfotransferase family
  6. NM_001388410.1NP_001375339.1  WSC domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104770
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl02568
    Location:245287
    WSC; WSC domain
  7. NM_001388411.1NP_001375340.1  WSC domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl02568
    Location:245287
    WSC; WSC domain
  8. NM_015253.2NP_056068.1  WSC domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056068.1

    Status: VALIDATED

    Source sequence(s)
    AC001231, AC104770, AL833730, BC009975, BE504506
    Consensus CDS
    CCDS32538.1
    UniProtKB/Swiss-Prot
    Q658N2, Q96G45
    Related
    ENSP00000323087.5, ENST00000317744.10
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:425517
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    6069116..6124427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435701.1XP_047291657.1  WSC domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96G45
  2. XM_047435702.1XP_047291658.1  WSC domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96G45
  3. XM_005256572.2XP_005256629.1  WSC domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005256629.1

    UniProtKB/Swiss-Prot
    Q658N2, Q96G45
    Conserved Domains (2) summary
    smart00321
    Location:142234
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:425517
    Sulfotransfer_3; Sulfotransferase family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    5963314..6018611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)