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FMO5 flavin containing dimethylaniline monoxygenase 5 [ Homo sapiens (human) ]

Gene ID: 2330, updated on 22-Aug-2021

Summary

Official Symbol
FMO5provided by HGNC
Official Full Name
flavin containing dimethylaniline monoxygenase 5provided by HGNC
Primary source
HGNC:HGNC:3773
See related
Ensembl:ENSG00000131781 MIM:603957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hBVMO1
Summary
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression
Biased expression in liver (RPKM 65.3), small intestine (RPKM 17.2) and 8 other tissues See more
Orthologs
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Genomic context

See FMO5 in Genome Data Viewer
Location:
1q21.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (147183963..147225798, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (146655884..146696931, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene chromodomain helicase DNA binding protein 1 like Neighboring gene protein disulfide isomerase family A member 3 pseudogene 1 Neighboring gene chaperonin containing TCP1 subunit 8 pseudogene 1 Neighboring gene ribosomal protein L7a pseudogene 15 Neighboring gene HNF4 motif-containing MPRA enhancer 9 Neighboring gene prostaglandin reductase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables NADPH oxidase H202-forming activity IEA
Inferred from Electronic Annotation
more info
 
enables aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in NADPH oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cholesterol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
flavin-containing monooxygenase 5
Names
FMO 5
NAPDH oxidase
baeyer-Villiger monooxygenase 1
dimethylaniline monooxygenase [N-oxide-forming] 5
dimethylaniline oxidase 5
flavin containing monooxygenase 5
hepatic flavin-containing monooxygenase 5
NP_001138301.1
NP_001138302.1
NP_001452.2
XP_005273003.1
XP_005273004.1
XP_005273005.1
XP_006711307.1
XP_006711308.1
XP_011507652.1
XP_011507653.1
XP_016856290.1
XP_016856291.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144829.3NP_001138301.1  flavin-containing monooxygenase 5 isoform 2

    See identical proteins and their annotated locations for NP_001138301.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and contains an alternate 3' terminal exon including coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK225739
    Consensus CDS
    CCDS44209.1
    UniProtKB/Swiss-Prot
    P49326
    Related
    ENSP00000416011.2, ENST00000441068.6
    Conserved Domains (2) summary
    pfam00743
    Location:3426
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_001144830.3NP_001138302.1  flavin-containing monooxygenase 5 isoform 3

    See identical proteins and their annotated locations for NP_001138302.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    BC035687, DA354058
    Consensus CDS
    CCDS44210.1
    UniProtKB/Swiss-Prot
    P49326
    Related
    ENSP00000358277.3, ENST00000369272.7
    Conserved Domains (1) summary
    cl26174
    Location:3279
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)
  3. NM_001461.4NP_001452.2  flavin-containing monooxygenase 5 isoform 1

    See identical proteins and their annotated locations for NP_001452.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK314647, BC035687
    Consensus CDS
    CCDS926.1
    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Related
    ENSP00000254090.4, ENST00000254090.9
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    147183963..147225798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711245.4XP_006711308.1  flavin-containing monooxygenase 5 isoform X4

    See identical proteins and their annotated locations for XP_006711308.1

    UniProtKB/Swiss-Prot
    P49326
    Conserved Domains (1) summary
    cl26174
    Location:3279
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)
  2. XM_005272947.5XP_005273004.1  flavin-containing monooxygenase 5 isoform X1

    See identical proteins and their annotated locations for XP_005273004.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. XM_011509350.3XP_011507652.1  flavin-containing monooxygenase 5 isoform X1

    See identical proteins and their annotated locations for XP_011507652.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  4. XM_005272948.5XP_005273005.1  flavin-containing monooxygenase 5 isoform X1

    See identical proteins and their annotated locations for XP_005273005.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  5. XM_005272946.5XP_005273003.1  flavin-containing monooxygenase 5 isoform X1

    See identical proteins and their annotated locations for XP_005273003.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  6. XM_017000802.2XP_016856291.1  flavin-containing monooxygenase 5 isoform X2

    Conserved Domains (2) summary
    pfam00743
    Location:3469
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  7. XM_017000801.2XP_016856290.1  flavin-containing monooxygenase 5 isoform X2

    Conserved Domains (2) summary
    pfam00743
    Location:3469
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  8. XM_011509351.3XP_011507653.1  flavin-containing monooxygenase 5 isoform X2

    Conserved Domains (2) summary
    pfam00743
    Location:3469
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  9. XM_006711244.4XP_006711307.1  flavin-containing monooxygenase 5 isoform X3

    Conserved Domains (2) summary
    pfam00743
    Location:3282
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
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