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BICD2 BICD cargo adaptor 2 [ Homo sapiens (human) ]

Gene ID: 23299, updated on 22-Aug-2020

Summary

Official Symbol
BICD2provided by HGNC
Official Full Name
BICD cargo adaptor 2provided by HGNC
Primary source
HGNC:HGNC:17208
See related
Ensembl:ENSG00000185963 MIM:609797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMALED2; SMALED2A; SMALED2B; bA526D8.1
Summary
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 24.1), esophagus (RPKM 14.2) and 24 other tissues See more
Orthologs

Genomic context

See BICD2 in Genome Data Viewer
Location:
9q22.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (92711363..92764841, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95473645..95527083, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987095 Neighboring gene Sharpr-MPRA regulatory region 2132 Neighboring gene ribosomal protein L21 pseudogene 86 Neighboring gene uncharacterized LOC101929748 Neighboring gene ankyrin repeat domain 19, pseudogene Neighboring gene RNA, U6 small nuclear 714, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Spinal muscular atrophy, lower extremity-predominant, 2A, autosomal dominant
MedGen: C4747715 OMIM: 615290 GeneReviews: Not available
Compare labs
SPINAL MUSCULAR ATROPHY, LOWER EXTREMITY-PREDOMINANT, 2B, PRENATAL ONSET, AUTOSOMAL DOMINANT
MedGen: C4749003 OMIM: 618291 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of bicaudal D homolog 2 (BICD2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with bicaudal D homolog 2 (BICD2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal adaptor activity IEA
Inferred from Electronic Annotation
more info
 
dynactin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynactin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
microtubule anchoring at microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule anchoring at microtubule organizing center ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
minus-end-directed organelle transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
annulate lamellae IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein bicaudal D homolog 2
Names
bic-D 2
bicaudal D homolog 2
coiled-coil protein BICD2
cytoskeleton-like bicaudal D protein homolog 2
homolog of Drosophila bicaudal D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033908.1 RefSeqGene

    Range
    4969..58439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003800.2NP_001003800.1  protein bicaudal D homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001003800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL136981, BC004296, BC010428, BC073970
    Consensus CDS
    CCDS35064.1
    UniProtKB/Swiss-Prot
    Q8TD16
    UniProtKB/TrEMBL
    Q96FU2
    Related
    ENSP00000349351.6, ENST00000356884.11
    Conserved Domains (1) summary
    pfam09730
    Location:83801
    BicD; Microtubule-associated protein Bicaudal-D
  2. NM_015250.4NP_056065.1  protein bicaudal D homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_056065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the shorter isoform (2). This variant includes an alternate intron, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL136981, AY052562, BC004296, BC010428
    Consensus CDS
    CCDS6700.1
    UniProtKB/Swiss-Prot
    Q8TD16
    UniProtKB/TrEMBL
    Q96FU2
    Related
    ENSP00000364662.3, ENST00000375512.3
    Conserved Domains (3) summary
    pfam09730
    Location:83801
    BicD; Microtubule-associated protein Bicaudal-D
    cl19219
    Location:55169
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:178230
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    92711363..92764841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014551.1XP_016870040.1  protein bicaudal D homolog 2 isoform X1

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