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BICD2 BICD cargo adaptor 2 [ Homo sapiens (human) ]

Gene ID: 23299, updated on 8-Jul-2018
Official Symbol
BICD2provided by HGNC
Official Full Name
BICD cargo adaptor 2provided by HGNC
Primary source
HGNC:HGNC:17208
See related
Ensembl:ENSG00000185963 MIM:609797; Vega:OTTHUMG00000021036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMALED2; bA526D8.1
Summary
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 24.1), esophagus (RPKM 14.2) and 24 other tissues See more
Orthologs
See BICD2 in Genome Data Viewer
Location:
9q22.31
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (92711363..92764841, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95473645..95527083, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987095 Neighboring gene ribosomal protein L21 pseudogene 86 Neighboring gene uncharacterized LOC101929748 Neighboring gene translation initiation factor IF-2-like Neighboring gene ankyrin repeat domain 19, pseudogene Neighboring gene RNA, U6 small nuclear 714, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Spinal muscular atrophy, lower extremity predominant 2, autosomal dominant
MedGen: C3809049 OMIM: 615290 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of bicaudal D homolog 2 (BICD2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with bicaudal D homolog 2 (BICD2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal adaptor activity IEA
Inferred from Electronic Annotation
more info
 
dynactin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
microtubule anchoring at microtubule organizing center ISS
Inferred from Sequence or Structural Similarity
more info
 
minus-end-directed organelle transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
annulate lamellae IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein bicaudal D homolog 2
Names
bic-D 2
bicaudal D homolog 2
coiled-coil protein BICD2
cytoskeleton-like bicaudal D protein homolog 2
homolog of Drosophila bicaudal D

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033908.1 RefSeqGene

    Range
    5001..58439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003800.1NP_001003800.1  protein bicaudal D homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001003800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC004296, BC010428, BC073970
    Consensus CDS
    CCDS35064.1
    UniProtKB/Swiss-Prot
    Q8TD16
    UniProtKB/TrEMBL
    Q96FU2
    Related
    ENSP00000349351.6, OTTHUMP00000022790, ENST00000356884.10, OTTHUMT00000055507
    Conserved Domains (1) summary
    pfam09730
    Location:83801
    BicD; Microtubule-associated protein Bicaudal-D
  2. NM_015250.3NP_056065.1  protein bicaudal D homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_056065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the shorter isoform (2). This variant includes an alternate intron, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY052562, BC004296, BC010428
    Consensus CDS
    CCDS6700.1
    UniProtKB/Swiss-Prot
    Q8TD16
    UniProtKB/TrEMBL
    Q96FU2
    Related
    ENSP00000364662.3, OTTHUMP00000022791, ENST00000375512.3, OTTHUMT00000055508
    Conserved Domains (3) summary
    pfam09730
    Location:83801
    BicD; Microtubule-associated protein Bicaudal-D
    cl19219
    Location:55169
    DUF342; Protein of unknown function (DUF342)
    cl19252
    Location:178230
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    92711363..92764841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014551.1XP_016870040.1  protein bicaudal D homolog 2 isoform X1

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