Zbtb45 zinc finger and BTB domain containing 45 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb45provided by MGI
Official Full Name: zinc finger and BTB domain containing 45provided by MGI
Primary source: MGI:MGI:2685003
See related: Ensembl:ENSMUSG00000049600 AllianceGenome:MGI:2685003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm157; Zfp499
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and forebrain. Orthologous to human ZBTB45 (zinc finger and BTB domain containing 45). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in thymus adult (RPKM 21.0), adrenal adult (RPKM 18.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 7.72 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (12737828..12745212, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (13005666..13010047, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Zbtb45 is a novel regulator of glial differentiation.
Title: The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 45

Names: zinc finger protein 499

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024699.2 → NP_001019870.1 zinc finger and BTB domain-containing protein 45

See identical proteins and their annotated locations for NP_001019870.1

Status: VALIDATED

Source sequence(s)

BC094359, BQ929674

Consensus CDS

CCDS20822.1

UniProtKB/Swiss-Prot

Q3TLP9, Q52KG4

Related

ENSMUSP00000147298.2, ENSMUST00000210282.2

Conserved Domains (4) summary

sd00017
Location:414 → 434

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:468 → 490

zf-C2H2; Zinc finger, C2H2 type

cd18229
Location:15 → 126

BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)

pfam13465
Location:454 → 479

zf-H2C2_2; Zinc-finger double domain
NM_001360833.1 → NP_001347762.1 zinc finger and BTB domain-containing protein 45

Status: VALIDATED

Source sequence(s)

AC121301, BC094359

Consensus CDS

CCDS20822.1

UniProtKB/Swiss-Prot

Q3TLP9, Q52KG4

Related

ENSMUSP00000056086.8, ENSMUST00000051390.9

Conserved Domains (4) summary

sd00017
Location:414 → 434

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:468 → 490

zf-C2H2; Zinc finger, C2H2 type

cd18229
Location:15 → 126

BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)

pfam13465
Location:454 → 479

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

12737828..12745212 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539803.3 → XP_006539866.1 zinc finger and BTB domain-containing protein 45 isoform X1

See identical proteins and their annotated locations for XP_006539866.1

UniProtKB/Swiss-Prot

Q3TLP9, Q52KG4

Conserved Domains (4) summary

sd00017
Location:414 → 434

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:468 → 490

zf-C2H2; Zinc finger, C2H2 type

cd18229
Location:15 → 126

BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)

pfam13465
Location:454 → 479

zf-H2C2_2; Zinc-finger double domain
XM_006539804.4 → XP_006539867.1 zinc finger and BTB domain-containing protein 45 isoform X1

See identical proteins and their annotated locations for XP_006539867.1

UniProtKB/Swiss-Prot

Q3TLP9, Q52KG4

Conserved Domains (4) summary

sd00017
Location:414 → 434

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:468 → 490

zf-C2H2; Zinc finger, C2H2 type

cd18229
Location:15 → 126

BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)

pfam13465
Location:454 → 479

zf-H2C2_2; Zinc-finger double domain