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Zbtb45 zinc finger and BTB domain containing 45 [ Mus musculus (house mouse) ]

Gene ID: 232879, updated on 8-Dec-2022

Summary

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Official Symbol
Zbtb45provided by MGI
Official Full Name
zinc finger and BTB domain containing 45provided by MGI
Primary source
MGI:MGI:2685003
See related
Ensembl:ENSMUSG00000049600 AllianceGenome:MGI:2685003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm157; Zfp499
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nervous system development. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and forebrain. Orthologous to human ZBTB45 (zinc finger and BTB domain containing 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 21.0), adrenal adult (RPKM 18.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb45 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12737828..12745212, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13005666..13010047, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 446 Neighboring gene solute carrier family 27 (fatty acid transporter), member 5 Neighboring gene CRISPRi-validated cis-regulatory element for Slc27a5, Trim28, Ube2m, Zbtb45, Zfp324 and Zfp446 Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. Södersten E, et al. Cell Cycle, 2010 Dec 15. PMID 21131782, Free PMC Article
  2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Zbtb45 is a novel regulator of glial differentiation.
    Title: The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC106784

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 45
Names
zinc finger protein 499

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024699.2 → NP_001019870.1  zinc finger and BTB domain-containing protein 45

    See identical proteins and their annotated locations for NP_001019870.1

    Status: VALIDATED

    Source sequence(s)
    BC094359, BQ929674
    Consensus CDS
    CCDS20822.1
    UniProtKB/Swiss-Prot
    Q3TLP9, Q52KG4
    Related
    ENSMUSP00000147298.2, ENSMUST00000210282.2
    Conserved Domains (4) summary
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:468 → 490
    zf-C2H2; Zinc finger, C2H2 type
    cd18229
    Location:15 → 126
    BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001360833.1 → NP_001347762.1  zinc finger and BTB domain-containing protein 45

    Status: VALIDATED

    Source sequence(s)
    AC121301, BC094359
    Consensus CDS
    CCDS20822.1
    UniProtKB/Swiss-Prot
    Q3TLP9
    Related
    ENSMUSP00000056086.8, ENSMUST00000051390.9
    Conserved Domains (4) summary
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:468 → 490
    zf-C2H2; Zinc finger, C2H2 type
    cd18229
    Location:15 → 126
    BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12737828..12745212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539803.3 → XP_006539866.1  zinc finger and BTB domain-containing protein 45 isoform X1

    See identical proteins and their annotated locations for XP_006539866.1

    UniProtKB/Swiss-Prot
    Q3TLP9, Q52KG4
    Conserved Domains (4) summary
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:468 → 490
    zf-C2H2; Zinc finger, C2H2 type
    cd18229
    Location:15 → 126
    BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006539804.4 → XP_006539867.1  zinc finger and BTB domain-containing protein 45 isoform X1

    See identical proteins and their annotated locations for XP_006539867.1

    UniProtKB/Swiss-Prot
    Q3TLP9, Q52KG4
    Conserved Domains (4) summary
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:468 → 490
    zf-C2H2; Zinc finger, C2H2 type
    cd18229
    Location:15 → 126
    BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
    pfam13465
    Location:454 → 479
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KG4.1 GenPept UniProtKB/Swiss-Prot:Q52KG4

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