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ADGRL3 adhesion G protein-coupled receptor L3 [ Homo sapiens (human) ]

Gene ID: 23284, updated on 12-Oct-2019

Summary

Official Symbol
ADGRL3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L3provided by HGNC
Primary source
HGNC:HGNC:20974
See related
Ensembl:ENSG00000150471 MIM:616417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL3; LEC3; CIRL3; LPHN3
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues See more
Orthologs

Genomic context

See ADGRL3 in Genome Data Viewer
Location:
4q13.1
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (61201230..62078335)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (62066949..62938168)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene microRNA 548ag-1 Neighboring gene long intergenic non-protein coding RNA 2271 Neighboring gene ribosomal protein L17 pseudogene 19 Neighboring gene ribosomal protein S12 pseudogene 9 Neighboring gene adhesion G protein-coupled receptor L3 antisense RNA 1 Neighboring gene uncharacterized LOC101927145 Neighboring gene ribosomal protein S15a pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
NHGRI GWA Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog

Pathways from BioSystems

  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor L3
Names
CIRL-3
calcium-independent alpha-latrotoxin receptor 3
latrophilin homolog 3 (cow)
latrophilin-3
lectomedin 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033950.2 RefSeqGene

    Range
    4975..882080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322246.2NP_001309175.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon in the 5' region and contains a novel exon in the 3' coding region; the latter causes a frameshift compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment in the 5' region and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB018311, AC007511, AC092643, AF307080, AK309793, BF511741, DA808156
    Consensus CDS
    CCDS82926.1
    UniProtKB/Swiss-Prot
    Q9HAR2
    Related
    ENSP00000423388.1, ENST00000512091.6
    Conserved Domains (7) summary
    smart00284
    Location:137393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495559
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8741119
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:43123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11401203
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:568786
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  2. NM_001322402.2NP_001309331.1  adhesion G protein-coupled receptor L3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007511, AC092643, AF307080, AK294689, AK309793, BF511741, DA808156
    UniProtKB/Swiss-Prot
    Q9HAR2
    UniProtKB/TrEMBL
    B7Z2G2
    Conserved Domains (8) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    COG0531
    Location:9521179
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12081537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636854
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  3. NM_001371342.1NP_001358271.1  adhesion G protein-coupled receptor L3 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
  4. NM_001371343.1NP_001358272.1  adhesion G protein-coupled receptor L3 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
  5. NM_001371344.1NP_001358273.1  adhesion G protein-coupled receptor L3 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
  6. NM_001371345.1NP_001358274.1  adhesion G protein-coupled receptor L3 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
  7. NM_001371346.1NP_001358275.1  adhesion G protein-coupled receptor L3 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007511, AC020741, AC092643, AC092663, AC092668, AC096723, AC108161
  8. NM_015236.6NP_056051.2  adhesion G protein-coupled receptor L3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056051.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 5' region compared to variant 1. The resulting isoform (2) is shorter missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB018311, AC007511, AC092643, AC092663, AC108161, AF307080, AK309793, BF511741
    Consensus CDS
    CCDS54768.1
    UniProtKB/Swiss-Prot
    Q9HAR2
    Related
    ENSP00000422533.1, ENST00000514591.5
    Conserved Domains (7) summary
    smart00284
    Location:137393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495559
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8741119
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:43123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11401469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:568786
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    61201230..62078335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007929.1XP_016863418.1  adhesion G protein-coupled receptor L3 isoform X1

  2. XM_017007931.1XP_016863420.1  adhesion G protein-coupled receptor L3 isoform X2

    UniProtKB/TrEMBL
    E7EUW2
    Related
    ENSP00000420931.1, ENST00000506720.5
  3. XM_017007940.1XP_016863429.1  adhesion G protein-coupled receptor L3 isoform X13

    UniProtKB/TrEMBL
    E7EUP0
    Related
    ENSP00000423787.1, ENST00000509896.5
    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12081271
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636854
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  4. XM_011531788.2XP_011530090.1  adhesion G protein-coupled receptor L3 isoform X3

    Conserved Domains (8) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    COG0531
    Location:9521179
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12081543
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636854
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  5. XM_017007932.1XP_016863421.1  adhesion G protein-coupled receptor L3 isoform X4

    Conserved Domains (8) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    COG0531
    Location:9521179
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12081537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636854
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  6. XM_017007941.1XP_016863430.1  adhesion G protein-coupled receptor L3 isoform X14

    UniProtKB/TrEMBL
    E7ESV6
    Related
    ENSP00000425033.1, ENST00000511324.5
  7. XM_017007933.1XP_016863422.1  adhesion G protein-coupled receptor L3 isoform X5

  8. XM_017007936.1XP_016863425.1  adhesion G protein-coupled receptor L3 isoform X8

  9. XM_011531791.2XP_011530093.1  adhesion G protein-coupled receptor L3 isoform X10

    Conserved Domains (8) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    COG0531
    Location:9391157
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11861515
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636841
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  10. XM_017007934.1XP_016863423.1  adhesion G protein-coupled receptor L3 isoform X6

  11. XM_017007942.1XP_016863431.1  adhesion G protein-coupled receptor L3 isoform X15

  12. XM_017007939.1XP_016863428.1  adhesion G protein-coupled receptor L3 isoform X12

  13. XM_017007935.1XP_016863424.1  adhesion G protein-coupled receptor L3 isoform X7

    UniProtKB/TrEMBL
    E7EVD6
    Related
    ENSP00000421372.1, ENST00000507625.5
    Conserved Domains (8) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    COG0531
    Location:9521170
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:9421178
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11991528
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:636854
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  14. XM_017007938.1XP_016863427.1  adhesion G protein-coupled receptor L3 isoform X11

  15. XM_017007930.1XP_016863419.1  adhesion G protein-coupled receptor L3 isoform X1

  16. XM_017007937.1XP_016863426.1  adhesion G protein-coupled receptor L3 isoform X9

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