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Kmt5c lysine methyltransferase 5C [ Mus musculus (house mouse) ]

Gene ID: 232811, updated on 11-Apr-2024

Summary

Official Symbol
Kmt5cprovided by MGI
Official Full Name
lysine methyltransferase 5Cprovided by MGI
Primary source
MGI:MGI:2385262
See related
Ensembl:ENSMUSG00000059851 AllianceGenome:MGI:2385262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Suv420h2; Suv4-20h2
Summary
Enables histone binding activity and histone methyltransferase activity (H4-K20 specific). Involved in positive regulation of isotype switching. Acts upstream of or within histone H4-K20 trimethylation. Located in condensed chromosome, centromeric region. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 51.2), colon adult (RPKM 39.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 A1; 7 2.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4743091..4750513)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4740092..4747514)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E127 Neighboring gene predicted gene, 24537 Neighboring gene predicted gene, 42369 Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene golgi associated RAB2 interactor family member 5B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC36471

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K20 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H4K20 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H4K20 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K20 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4K20me methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase KMT5C
Names
[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B
[histone H4]-lysine20 N-methyltransferase KMT5B
histone-lysine N-methyltransferase SUV420H2
lysine-specific methyltransferase 5C
su(var)4-20 homolog 2
suppressor of variegation 4-20 homolog 2
NP_001108490.1
NP_001344973.1
NP_001407571.1
NP_001407572.1
NP_001407573.1
NP_001407574.1
NP_001407575.1
NP_001407576.1
NP_001407577.1
NP_001407578.1
NP_666289.2
XP_006539834.1
XP_006539835.1
XP_036008833.1
XP_036008834.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115018.2NP_001108490.1  histone-lysine N-methyltransferase KMT5C isoform 1

    See identical proteins and their annotated locations for NP_001108490.1

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20743.2
    UniProtKB/Swiss-Prot
    Q5RKP6, Q6Q783, Q8R1C5
    Related
    ENSMUSP00000096452.3, ENSMUST00000098853.9
    Conserved Domains (2) summary
    smart00317
    Location:120224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl25800
    Location:245366
    GGN; Gametogenetin
  2. NM_001358044.2NP_001344973.1  histone-lysine N-methyltransferase KMT5C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20743.2
    UniProtKB/Swiss-Prot
    Q5RKP6, Q6Q783, Q8R1C5
    Related
    ENSMUSP00000104223.4, ENSMUST00000108582.10
    Conserved Domains (2) summary
    smart00317
    Location:120224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl25800
    Location:245366
    GGN; Gametogenetin
  3. NM_001420642.1NP_001407571.1  histone-lysine N-methyltransferase KMT5C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161197
  4. NM_001420643.1NP_001407572.1  histone-lysine N-methyltransferase KMT5C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161197
  5. NM_001420644.1NP_001407573.1  histone-lysine N-methyltransferase KMT5C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161197
  6. NM_001420645.1NP_001407574.1  histone-lysine N-methyltransferase KMT5C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161197
  7. NM_001420646.1NP_001407575.1  histone-lysine N-methyltransferase KMT5C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC161197
  8. NM_001420647.1NP_001407576.1  histone-lysine N-methyltransferase KMT5C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC161197
  9. NM_001420648.1NP_001407577.1  histone-lysine N-methyltransferase KMT5C isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC161197
  10. NM_001420649.1NP_001407578.1  histone-lysine N-methyltransferase KMT5C isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC161197
  11. NM_146177.3NP_666289.2  histone-lysine N-methyltransferase KMT5C isoform 1

    See identical proteins and their annotated locations for NP_666289.2

    Status: VALIDATED

    Source sequence(s)
    AC161197
    Consensus CDS
    CCDS20743.2
    UniProtKB/Swiss-Prot
    Q5RKP6, Q6Q783, Q8R1C5
    Related
    ENSMUSP00000104224.3, ENSMUST00000108583.9
    Conserved Domains (2) summary
    smart00317
    Location:120224
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cl25800
    Location:245366
    GGN; Gametogenetin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4743091..4750513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539772.1XP_006539835.1  histone-lysine N-methyltransferase KMT5C isoform X1

    See identical proteins and their annotated locations for XP_006539835.1

    Conserved Domains (2) summary
    PHA02682
    Location:281346
    PHA02682; ORF080 virion core protein; Provisional
    cl40432
    Location:196279
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  2. XM_036152941.1XP_036008834.1  histone-lysine N-methyltransferase KMT5C isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:276397
    PHA02682; ORF080 virion core protein; Provisional
    cd19185
    Location:102274
    SET_KMT5C; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins
  3. XM_006539771.5XP_006539834.1  histone-lysine N-methyltransferase KMT5C isoform X1

    See identical proteins and their annotated locations for XP_006539834.1

    Conserved Domains (2) summary
    PHA02682
    Location:281346
    PHA02682; ORF080 virion core protein; Provisional
    cl40432
    Location:196279
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  4. XM_036152940.1XP_036008833.1  histone-lysine N-methyltransferase KMT5C isoform X2

    Conserved Domains (2) summary
    PHA02682
    Location:276397
    PHA02682; ORF080 virion core protein; Provisional
    cd19185
    Location:102274
    SET_KMT5C; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins