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MTUS2 microtubule associated scaffold protein 2 [ Homo sapiens (human) ]

Gene ID: 23281, updated on 26-Oct-2022

Summary

Official Symbol
MTUS2provided by HGNC
Official Full Name
microtubule associated scaffold protein 2provided by HGNC
Primary source
HGNC:HGNC:20595
See related
Ensembl:ENSG00000132938 MIM:619358; AllianceGenome:HGNC:20595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICIS; CAZIP; TIP150; KIAA0774
Summary
Enables microtubule binding activity and protein homodimerization activity. Part of nucleus. Colocalizes with centrosome and cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 7.4), ovary (RPKM 1.3) and 4 other tissues See more
Orthologs
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Genomic context

See MTUS2 in Genome Data Viewer
Location:
13q12.3
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (28819963..29505947)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (28043215..28728869)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (29394100..30080084)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8918 Neighboring gene POM121 transmembrane nucleoporin like 13, pseudogene Neighboring gene uncharacterized LOC124903144 Neighboring gene Sharpr-MPRA regulatory region 9111 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 69 Neighboring gene Sharpr-MPRA regulatory region 1517 Neighboring gene MTUS2 antisense RNA 1 Neighboring gene solute carrier family 7 member 1 Neighboring gene uncharacterized LOC102723345

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
EBI GWAS Catalog
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0774

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated tumor suppressor candidate 2
Names
+TIP of 150 kDa
cardiac zipper protein
microtubule associated tumor suppressor candidate 2
microtubule plus-end tracking protein TIP150
tracking protein of 150 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033602.4NP_001028774.3  microtubule-associated tumor suppressor candidate 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL160255, AL359741, AL596092, AL596114, AL607144
    Consensus CDS
    CCDS45022.2
    UniProtKB/Swiss-Prot
    Q8N5E2
    Related
    ENSP00000483729.2, ENST00000612955.6
    Conserved Domains (3) summary
    PHA03247
    Location:640993
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:10661329
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam13851
    Location:10001117
    GAS; Growth-arrest specific micro-tubule binding
  2. NM_001366650.1NP_001353579.1  microtubule-associated tumor suppressor candidate 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL160255, AL359741, AL596092, AL596114, AL607144
    Conserved Domains (3) summary
    cl25496
    Location:524931
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl25549
    Location:9861117
    ARGLU; Arginine and glutamate-rich 1
    cl25732
    Location:10651328
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001366651.1NP_001353580.1  microtubule-associated tumor suppressor candidate 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL160255, AL359741, AL596092, AL596114, AL607144
    Conserved Domains (2) summary
    cl25732
    Location:10001263
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:394945
    Atrophin-1; Atrophin-1 family
  4. NM_001384605.1NP_001371534.1  microtubule-associated tumor suppressor candidate 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL160255, AL359741, AL596092, AL596114, AL607144
    Consensus CDS
    CCDS45022.2
    UniProtKB/Swiss-Prot
    Q8N5E2
    Conserved Domains (3) summary
    PHA03247
    Location:640993
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:10661329
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam13851
    Location:10001117
    GAS; Growth-arrest specific micro-tubule binding
  5. NM_001384606.1NP_001371535.1  microtubule-associated tumor suppressor candidate 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL160255, AL359741, AL596092, AL596114, AL607144
    Consensus CDS
    CCDS45022.2
    UniProtKB/Swiss-Prot
    Q8N5E2
    Conserved Domains (3) summary
    PHA03247
    Location:640993
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:10661329
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    pfam13851
    Location:10001117
    GAS; Growth-arrest specific micro-tubule binding
  6. NM_015233.6NP_056048.1  microtubule-associated tumor suppressor candidate 2 isoform b

    See identical proteins and their annotated locations for NP_056048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AL596114, BC032481, BC129985, BU788127
    Consensus CDS
    CCDS41874.1
    UniProtKB/Swiss-Prot
    Q5JR59
    Related
    ENSP00000370186.2, ENST00000380808.6
    Conserved Domains (1) summary
    TIGR02168
    Location:25298
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    28819963..29505947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430227.1XP_047286183.1  microtubule-associated tumor suppressor candidate 2 isoform X1

  2. XM_011535019.4XP_011533321.1  microtubule-associated tumor suppressor candidate 2 isoform X1

    Conserved Domains (4) summary
    pfam15665
    Location:11471364
    FAM184; Family with sequence similarity 184, A and B
    cd16269
    Location:11531164
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:10771181
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl23720
    Location:12441364
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. XM_047430228.1XP_047286184.1  microtubule-associated tumor suppressor candidate 2 isoform X1

  4. XM_047430229.1XP_047286185.1  microtubule-associated tumor suppressor candidate 2 isoform X2

  5. XM_017020500.3XP_016875989.1  microtubule-associated tumor suppressor candidate 2 isoform X3

  6. XM_017020501.3XP_016875990.1  microtubule-associated tumor suppressor candidate 2 isoform X4

  7. XM_011535022.2XP_011533324.1  microtubule-associated tumor suppressor candidate 2 isoform X5

    See identical proteins and their annotated locations for XP_011533324.1

    Conserved Domains (2) summary
    cl25732
    Location:272535
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27109
    Location:37182
    Herpes_UL49_2; Herpesvirus UL49 tegument protein
  8. XM_024449335.2XP_024305103.1  microtubule-associated tumor suppressor candidate 2 isoform X5

    Conserved Domains (2) summary
    cl25732
    Location:272535
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27109
    Location:37182
    Herpes_UL49_2; Herpesvirus UL49 tegument protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    28043215..28728869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)