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Cnot3 CCR4-NOT transcription complex, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 232791, updated on 22-Sep-2022

Summary

Official Symbol
Cnot3provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 3provided by MGI
Primary source
MGI:MGI:2385261
See related
Ensembl:ENSMUSG00000035632 AllianceGenome:MGI:2385261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930039N10Rik
Summary
Involved in positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; brain; gonad; hemolymphoid system gland; and white fat. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.9), limb E14.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cnot3 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3646717..3664108)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3645247..3661109)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (3596871..3612711)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TCF3 (E2A) fusion partner Neighboring gene pre-mRNA processing factor 31 Neighboring gene predicted gene 15927 Neighboring gene microRNA 3572 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene tRNA splicing endonuclease subunit 34

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40675

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
 
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 3
Names
CCR4-associated factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146176.3NP_666288.1  CCR4-NOT transcription complex subunit 3

    See identical proteins and their annotated locations for NP_666288.1

    Status: VALIDATED

    Source sequence(s)
    BC053437, BQ748712, CV783268
    Consensus CDS
    CCDS20721.1
    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Related
    ENSMUSP00000039098.10, ENSMUST00000038913.16
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3646717..3664108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152919.1XP_036008812.1  CCR4-NOT transcription complex subunit 3 isoform X1

    Conserved Domains (2) summary
    COG5665
    Location:210929
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:211409
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  2. XM_036152920.1XP_036008813.1  CCR4-NOT transcription complex subunit 3 isoform X2

    Conserved Domains (2) summary
    COG5665
    Location:210928
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:211408
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  3. XM_036152921.1XP_036008814.1  CCR4-NOT transcription complex subunit 3 isoform X3

    Conserved Domains (2) summary
    COG5665
    Location:209928
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:210408
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  4. XM_036152922.1XP_036008815.1  CCR4-NOT transcription complex subunit 3 isoform X4

    Conserved Domains (3) summary
    pfam05109
    Location:477744
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam04065
    Location:211409
    Not3; Not1 N-terminal domain, CCR4-Not complex component
    cl02384
    Location:798860
    NOT2_3_5; NOT2 / NOT3 / NOT5 family
  5. XM_006539756.5XP_006539819.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539819.1

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  6. XM_030242409.2XP_030098269.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  7. XM_036152924.1XP_036008817.1  CCR4-NOT transcription complex subunit 3 isoform X6

    Conserved Domains (2) summary
    COG5665
    Location:130849
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:131329
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  8. XM_006539752.5XP_006539815.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539815.1

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  9. XM_036152927.1XP_036008820.1  CCR4-NOT transcription complex subunit 3 isoform X7

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  10. XM_036152930.1XP_036008823.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  11. XM_006539753.5XP_006539816.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539816.1

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  12. XM_030242407.2XP_030098267.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  13. XM_017322146.3XP_017177635.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7, Q8K0V4
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  14. XM_036152928.1XP_036008821.1  CCR4-NOT transcription complex subunit 3 isoform X7

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  15. XM_006539755.5XP_006539818.1  CCR4-NOT transcription complex subunit 3 isoform X7

    See identical proteins and their annotated locations for XP_006539818.1

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  16. XM_036152923.1XP_036008816.1  CCR4-NOT transcription complex subunit 3 isoform X5

    Conserved Domains (2) summary
    COG5665
    Location:131850
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:132330
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  17. XM_030242406.2XP_030098266.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  18. XM_036152926.1XP_036008819.1  CCR4-NOT transcription complex subunit 3 isoform X7

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  19. XM_030242408.2XP_030098268.1  CCR4-NOT transcription complex subunit 3 isoform X8

    UniProtKB/Swiss-Prot
    B2RUA7
    UniProtKB/TrEMBL
    A0A8C6GLX8
    Conserved Domains (2) summary
    COG5665
    Location:12749
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3229
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  20. XM_036152931.1XP_036008824.1  CCR4-NOT transcription complex subunit 3 isoform X9

    Conserved Domains (1) summary
    COG5665
    Location:1663
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
  21. XM_036152929.1XP_036008822.1  CCR4-NOT transcription complex subunit 3 isoform X7

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component
  22. XM_036152925.1XP_036008818.1  CCR4-NOT transcription complex subunit 3 isoform X7

    Conserved Domains (2) summary
    COG5665
    Location:12750
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    pfam04065
    Location:3230
    Not3; Not1 N-terminal domain, CCR4-Not complex component

RNA

  1. XR_004934061.1 RNA Sequence

  2. XR_003946437.2 RNA Sequence