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CLUH clustered mitochondria homolog [ Homo sapiens (human) ]

Gene ID: 23277, updated on 6-Nov-2022

Summary

Official Symbol
CLUHprovided by HGNC
Official Full Name
clustered mitochondria homologprovided by HGNC
Primary source
HGNC:HGNC:29094
See related
Ensembl:ENSG00000132361 MIM:616184; AllianceGenome:HGNC:29094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLU1
Summary
Enables mRNA binding activity. Involved in intracellular distribution of mitochondria. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 25.8), duodenum (RPKM 18.1) and 25 other tissues See more
Orthologs
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Genomic context

See CLUH in Genome Data Viewer
Location:
17p13.3
Exon count:
31
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2689387..2712020, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (2578517..2601136, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2592681..2615314, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene platelet activating factor acetylhydrolase 1b regulatory subunit 1 Neighboring gene RNA, 7SL, cytoplasmic 608, pseudogene Neighboring gene uncharacterized LOC105371490 Neighboring gene microRNA 6776 Neighboring gene uncharacterized LOC105371592 Neighboring gene coiled-coil domain containing 92B Neighboring gene microRNA 1253

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23672, KIAA0664, DKFZp686L05242, DKFZp686M09233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
clustered mitochondria protein homolog
Names
clustered mitochondria (cluA/CLU1) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366661.1NP_001353590.1  clustered mitochondria protein homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005696
    Consensus CDS
    CCDS92221.1
    UniProtKB/TrEMBL
    A0A494C0R8
    Related
    ENSP00000498679.1, ENST00000651024.2
    Conserved Domains (5) summary
    sd00006
    Location:10611087
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:806987
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394614
    CLU; Clustered mitochondria
    pfam13424
    Location:11411216
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:104177
    CLU_N; Mitochondrial function, CLU-N-term
  2. NM_001366662.1NP_001353591.1  clustered mitochondria protein homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005696
    Consensus CDS
    CCDS92220.1
    UniProtKB/Swiss-Prot
    Q9H979
    Related
    ENSP00000458986.1, ENST00000570628.6
    Conserved Domains (5) summary
    sd00006
    Location:10221048
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:767948
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11021177
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  3. NM_015229.4NP_056044.4  clustered mitochondria protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB014564, AC005696, AK125717, AW291521, BC033614, HY024625
    Consensus CDS
    CCDS45572.1
    Conserved Domains (5) summary
    sd00006
    Location:10601086
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:805986
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394614
    CLU; Clustered mitochondria
    pfam13424
    Location:11401215
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:104177
    CLU_N; Mitochondrial function, CLU-N-term

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    2689387..2712020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435694.1XP_047291650.1  clustered mitochondria protein homolog isoform X4

    UniProtKB/Swiss-Prot
    Q9H979
    Related
    ENSP00000388872.1, ENST00000435359.5
  2. XM_011523768.4XP_011522070.1  clustered mitochondria protein homolog isoform X3

    Conserved Domains (5) summary
    sd00006
    Location:10231049
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:768949
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11031178
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  3. XM_024450679.2XP_024306447.1  clustered mitochondria protein homolog isoform X3

    Conserved Domains (5) summary
    sd00006
    Location:10231049
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:768949
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11031178
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  4. XM_047435695.1XP_047291651.1  clustered mitochondria protein homolog isoform X4

    UniProtKB/Swiss-Prot
    Q9H979
  5. XM_047435693.1XP_047291649.1  clustered mitochondria protein homolog isoform X3

  6. XM_024450676.2XP_024306444.2  clustered mitochondria protein homolog isoform X2

  7. XM_024450675.2XP_024306443.2  clustered mitochondria protein homolog isoform X1

  8. XM_047435692.1XP_047291648.1  clustered mitochondria protein homolog isoform X3

    Related
    ENSP00000464732.2, ENST00000575014.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    2578517..2601136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)