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CLUH clustered mitochondria homolog [ Homo sapiens (human) ]

Gene ID: 23277, updated on 1-Jun-2020

Summary

Official Symbol
CLUHprovided by HGNC
Official Full Name
clustered mitochondria homologprovided by HGNC
Primary source
HGNC:HGNC:29094
See related
Ensembl:ENSG00000132361 MIM:616184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLU1
Expression
Ubiquitous expression in kidney (RPKM 25.8), duodenum (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See CLUH in Genome Data Viewer
Location:
17p13.3
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (2689387..2712020, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2592680..2615053, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene platelet activating factor acetylhydrolase 1b regulatory subunit 1 Neighboring gene sterile alpha motif domain containing 11 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 608, pseudogene Neighboring gene uncharacterized LOC105371490 Neighboring gene microRNA 6776 Neighboring gene uncharacterized LOC105371592 Neighboring gene coiled-coil domain containing 92B Neighboring gene microRNA 1253

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23672, KIAA0664, DKFZp686L05242, DKFZp686M09233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
clustered mitochondria protein homolog
Names
clustered mitochondria (cluA/CLU1) homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366661.1NP_001353590.1  clustered mitochondria protein homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005696
    Related
    ENSP00000498679.1, ENST00000651024.1
    Conserved Domains (5) summary
    sd00006
    Location:10611087
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:806987
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394614
    CLU; Clustered mitochondria
    pfam13424
    Location:11411216
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:104177
    CLU_N; Mitochondrial function, CLU-N-term
  2. NM_001366662.1NP_001353591.1  clustered mitochondria protein homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005696
    Related
    ENSP00000458986.1, ENST00000570628.6
    Conserved Domains (5) summary
    sd00006
    Location:10221048
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:767948
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11021177
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  3. NM_015229.4NP_056044.4  clustered mitochondria protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB014564, AC005696, AK125717, AW291521, BC033614, HY024625
    Consensus CDS
    CCDS45572.1
    Conserved Domains (5) summary
    sd00006
    Location:10601086
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:805986
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394614
    CLU; Clustered mitochondria
    pfam13424
    Location:11401215
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:104177
    CLU_N; Mitochondrial function, CLU-N-term

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    2689387..2712020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523768.3XP_011522070.1  clustered mitochondria protein homolog isoform X5

    Related
    ENSP00000464732.2, ENST00000575014.5
    Conserved Domains (5) summary
    sd00006
    Location:10231049
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:768949
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11031178
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  2. XM_024450680.1XP_024306448.1  clustered mitochondria protein homolog isoform X5

    Conserved Domains (5) summary
    sd00006
    Location:10231049
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:768949
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11031178
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  3. XM_024450679.1XP_024306447.1  clustered mitochondria protein homolog isoform X5

    Conserved Domains (5) summary
    sd00006
    Location:10231049
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:768949
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam13424
    Location:11031178
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term
  4. XM_024450676.1XP_024306444.1  clustered mitochondria protein homolog isoform X2

    Conserved Domains (6) summary
    sd00006
    Location:12951321
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:10401221
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:629849
    CLU; Clustered mitochondria
    pfam13424
    Location:13751450
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:339412
    CLU_N; Mitochondrial function, CLU-N-term
    cl28033
    Location:114307
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  5. XM_024450675.1XP_024306443.1  clustered mitochondria protein homolog isoform X1

    Conserved Domains (6) summary
    sd00006
    Location:12961322
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:10411222
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:629849
    CLU; Clustered mitochondria
    pfam13424
    Location:13761451
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:339412
    CLU_N; Mitochondrial function, CLU-N-term
    cl28033
    Location:114307
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
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