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TASOR transcription activation suppressor [ Homo sapiens (human) ]

Gene ID: 23272, updated on 4-Jul-2021

Summary

Official Symbol
TASORprovided by HGNC
Official Full Name
transcription activation suppressorprovided by HGNC
Primary source
HGNC:HGNC:30314
See related
Ensembl:ENSG00000163946 MIM:616493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAP140; TASOR1; se89-1; C3orf63; FAM208A
Expression
Ubiquitous expression in testis (RPKM 15.9), lymph node (RPKM 11.5) and 25 other tissues See more
Orthologs
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Genomic context

See TASOR in Genome Data Viewer
Location:
3p14.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (56620132..56683265, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (56654160..56717293, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene uncharacterized LOC105377099 Neighboring gene Sharpr-MPRA regulatory region 10072 Neighboring gene coiled-coil domain containing 66 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene ARHGEF3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6639

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of C3orf63 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
Knockdown of family with sequence similarity 208, member A (FAM208A; C3orf63) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1105, DKFZp686C2456

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein TASOR
Names
CTCL tumor antigen se89-1
family with sequence similarity 208 member A
protein FAM208A
retinoblastoma-associated protein 140
retinoblastoma-associated protein RAP140
transgene activation suppressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112736.2NP_001106207.1  protein TASOR isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant contains an alternate 3' terminal exon, resulting in a frameshift compared to variant 4. The encoded isoform (a) has a novel C-terminus, and is shorter compared to isoform d.
    Source sequence(s)
    AC099781, AK094486, BC129987, BI559851, BX648955
    Consensus CDS
    CCDS46853.1
    UniProtKB/Swiss-Prot
    Q9UK61
    Related
    ENSP00000417509.2, ENST00000493960.6
    Conserved Domains (1) summary
    pfam12509
    Location:158319
    DUF3715; Protein of unknown function (DUF3715)
  2. NM_001363940.1NP_001350869.1  protein TASOR isoform c

    Status: VALIDATED

    Source sequence(s)
    AC099781
    Consensus CDS
    CCDS87094.1
    Related
    ENSP00000347845.5, ENST00000355628.9
    Conserved Domains (2) summary
    pfam12300
    Location:53110
    RhlB; ATP-dependent RNA helicase RhlB
    pfam12509
    Location:166319
    DUF3715; Protein of unknown function (DUF3715)
  3. NM_001365635.2NP_001352564.1  protein TASOR isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (d).
    Source sequence(s)
    AC099781
    Related
    ENSP00000508241.1, ENST00000683822.1
    Conserved Domains (2) summary
    pfam12300
    Location:53110
    RhlB; ATP-dependent RNA helicase RhlB
    pfam12509
    Location:166319
    DUF3715; Protein of unknown function (DUF3715)
  4. NM_001365636.2NP_001352565.1  protein TASOR isoform e

    Status: VALIDATED

    Source sequence(s)
    AC099781
    Conserved Domains (2) summary
    pfam12300
    Location:53110
    RhlB; ATP-dependent RNA helicase RhlB
    pfam12509
    Location:166319
    DUF3715; Protein of unknown function (DUF3715)
  5. NM_001365637.2NP_001352566.1  protein TASOR isoform f

    Status: VALIDATED

    Source sequence(s)
    AC099781
    Conserved Domains (2) summary
    pfam12300
    Location:53110
    RhlB; ATP-dependent RNA helicase RhlB
    pfam12509
    Location:166319
    DUF3715; Protein of unknown function (DUF3715)
  6. NM_001365638.2NP_001352567.1  protein TASOR isoform g

    Status: VALIDATED

    Source sequence(s)
    AC099781
    Conserved Domains (2) summary
    pfam12300
    Location:53110
    RhlB; ATP-dependent RNA helicase RhlB
    pfam12509
    Location:166319
    DUF3715; Protein of unknown function (DUF3715)
  7. NM_015224.3NP_056039.2  protein TASOR isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 5' coding exons and uses a downstream start codon compared to variant 4. The encoded isoform (b) has a shorter N-terminus compared to isoform d.
    Source sequence(s)
    AC099781, BC029354, BC129987
    Consensus CDS
    CCDS2877.1
    UniProtKB/Swiss-Prot
    Q9UK61
    Related
    ENSP00000399410.2, ENST00000431842.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    56620132..56683265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713078.2XP_006713141.1  protein TASOR isoform X6

    Related
    ENSP00000483340.1, ENST00000614531.1
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