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FMO2 flavin containing dimethylaniline monoxygenase 2 [ Homo sapiens (human) ]

Gene ID: 2327, updated on 1-Jun-2020

Summary

Official Symbol
FMO2provided by HGNC
Official Full Name
flavin containing dimethylaniline monoxygenase 2provided by HGNC
Primary source
HGNC:HGNC:3770
See related
Ensembl:ENSG00000094963 MIM:603955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMO1B1
Summary
This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Biased expression in fat (RPKM 59.7), lung (RPKM 58.7) and 8 other tissues See more
Orthologs

Genomic context

See FMO2 in Genome Data Viewer
Location:
1q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (171185208..171212686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171154388..171181822)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 1295a Neighboring gene microRNA 1295b Neighboring gene uncharacterized LOC105371611 Neighboring gene flavin containing dimethylaniline monoxygenase 3 Neighboring gene flavin containing dimethylaniline monoxygenase 6, pseudogene Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene high mobility group box 1 pseudogene 11 Neighboring gene flavin containing dimethylaniline monoxygenase 4 Neighboring gene DNA topoisomerase I pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40826

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N,N-dimethylaniline monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NADP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NADPH oxidation IDA
Inferred from Direct Assay
more info
PubMed 
drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
organic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxygen metabolic process IEA
Inferred from Electronic Annotation
more info
 
toxin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 2
Names
FMO, pulmonary
dimethylaniline oxidase 2
flavin containing monooxygenase 2 (non-functional)
pulmonary flavin-containing monooxygenase 2
NP_001288276.1
NP_001352829.1
NP_001451.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301347.2NP_001288276.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform b

    See identical proteins and their annotated locations for NP_001288276.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI821378, AK098145, AK304385, AL021026, AL833218, KF459607, R95468
    UniProtKB/TrEMBL
    B4E2Q9, Q5JPC7
    Conserved Domains (1) summary
    pfam00743
    Location:1312
    FMO-like; Flavin-binding monooxygenase-like
  2. NM_001365900.1NP_001352829.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL021026, KF459607
    Conserved Domains (1) summary
    cl26174
    Location:1467
    K_oxygenase; L-lysine 6-monooxygenase (NADPH-requiring)
  3. NM_001460.5NP_001451.2  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), which represents the functional FMO2*1 allele, is the longer transcript and encodes the longer isoform (a)
    Source sequence(s)
    AI821378, AK098145, AL021026, AL833218, BC005894, DB224311, KF459607, R95468
    Consensus CDS
    CCDS1293.2
    UniProtKB/Swiss-Prot
    Q99518
    UniProtKB/TrEMBL
    Q5JPC7
    Related
    ENSP00000209929.8, ENST00000209929.10
    Conserved Domains (2) summary
    pfam00743
    Location:2532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:758
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_160266.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL021026, KF459607

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    171185208..171212686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_921761.3 RNA Sequence

  2. XR_001737072.2 RNA Sequence

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