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Zc3hc1 zinc finger, C3HC type 1 [ Mus musculus (house mouse) ]

Gene ID: 232679, updated on 8-Feb-2024

Summary

Official Symbol
Zc3hc1provided by MGI
Official Full Name
zinc finger, C3HC type 1provided by MGI
Primary source
MGI:MGI:1916023
See related
Ensembl:ENSMUSG00000039130 AllianceGenome:MGI:1916023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nipa; HSPC216; 1110054L24Rik
Summary
Predicted to enable protein kinase binding activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in nucleus. Orthologous to human ZC3HC1 (zinc finger C3HC-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.5) and 28 other tissues See more
Orthologs
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Genomic context

See Zc3hc1 in Genome Data Viewer
Location:
6 A3.3; 6 12.52 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30366383..30391019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30366384..30391049, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2H Neighboring gene STARR-seq mESC enhancer starr_15462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30250507-30250717 Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene STARR-positive B cell enhancer ABC_E6420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30351601-30351833 Neighboring gene kelch domain containing 10 Neighboring gene RIKEN cDNA 1700012C14 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger C3HC-type protein 1
Names
nuclear interacting partner of anaplastic lymphoma kinase (Alk)
nuclear-interacting partner of ALK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311086.1NP_001298015.1  zinc finger C3HC-type protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001298015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK151694, BC050141, BY235523
    Consensus CDS
    CCDS80508.1
    UniProtKB/Swiss-Prot
    Q3TJE6, Q80YV2, Q80Z11, Q8BTW5, Q8CI56, Q8R3U7
    UniProtKB/TrEMBL
    Q3TI64
    Related
    ENSMUSP00000079627.8, ENSMUST00000080812.14
    Conserved Domains (2) summary
    pfam07967
    Location:73201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248337
    Rsm1; Rsm1-like
  2. NM_172735.3NP_766323.1  zinc finger C3HC-type protein 1 isoform 2

    See identical proteins and their annotated locations for NP_766323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC155848, AC160148
    Consensus CDS
    CCDS19970.1
    UniProtKB/TrEMBL
    Q3TI64
    Related
    ENSMUSP00000100057.4, ENSMUST00000102992.10
    Conserved Domains (3) summary
    PTZ00449
    Location:302476
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07967
    Location:73201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248337
    Rsm1; Rsm1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30366383..30391019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321571.3XP_017177060.1  zinc finger C3HC-type protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TI64
    Conserved Domains (3) summary
    PTZ00449
    Location:302476
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07967
    Location:73201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248337
    Rsm1; Rsm1-like