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ADGRL2 adhesion G protein-coupled receptor L2 [ Homo sapiens (human) ]

Gene ID: 23266, updated on 10-Nov-2018

Summary

Official Symbol
ADGRL2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L2provided by HGNC
Primary source
HGNC:HGNC:18582
See related
Ensembl:ENSG00000117114 MIM:607018; Vega:OTTHUMG00000009844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL2; LEC1; CIRL2; LPHH1; LPHN2
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in thyroid (RPKM 16.1), lung (RPKM 14.8) and 23 other tissues See more
Orthologs

Genomic context

See ADGRL2 in Genome Data Viewer
Location:
1p31.1
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (81306104..81993932)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (82266082..82458107)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985018 Neighboring gene RNA, 7SK small nuclear pseudogene 247 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 14 Neighboring gene uncharacterized LOC101927434 Neighboring gene AT-rich interaction domain 3B pseudogene Neighboring gene ribosomal protein S20 pseudogene 7 Neighboring gene ST13, Hsp70 interacting protein pseudogene 20 Neighboring gene uncharacterized LOC105378814 Neighboring gene uncharacterized LOC107985396 Neighboring gene VISTA enhancer hs442

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
NHGRI GWA Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
UGT1A1 is a major locus influencing bilirubin levels in African Americans.
NHGRI GWA Catalog

Pathways from BioSystems

  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
latrotoxin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor L2
Names
calcium-independent alpha-latrotoxin receptor 2
latrophilin homolog 1
latrophilin-2
lectomedin-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297704.2NP_001284633.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC113949, AF104939, AJ131581, AL358939, AW008295, BM983870, CA429938
    Consensus CDS
    CCDS689.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000353006.2, OTTHUMP00000011441, ENST00000359929.7
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  2. NM_001297705.2NP_001284634.1  adhesion G protein-coupled receptor L2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 5. The encoded isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC113949, AF104266, AF104939, AL157903, AL358939, AL359705, AW008295, BM983870, CA429938
    Consensus CDS
    CCDS72811.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000359750.1, OTTHUMP00000011442, ENST00000370715.5
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871162
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  3. NM_001297706.2NP_001284635.1  adhesion G protein-coupled receptor L2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001284635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons compared to variant 5. The encoded isoform (3) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC113949, AF104938, AF104939, AL157903, AL358939, AL359705, AW008295, BM983870, CA429938
    Consensus CDS
    CCDS76174.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000359748.1, OTTHUMP00000011443, ENST00000370713.5
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871120
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  4. NM_001330645.2NP_001317574.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform 4.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705, BM983870, CA429938
    Consensus CDS
    CCDS81345.1
    UniProtKB/Swiss-Prot
    O95490
    Conserved Domains (7) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8441101
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  5. NM_001350698.1NP_001337627.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AB018329, AC113949, AJ131581, AL157903, AW008295, CA429938, DA764511
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  6. NM_001350699.1NP_001337628.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AB018329, AC113949, AJ131581, AL358939, AW008295, CA429938, DB227081
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871153
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:834858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. NM_001366002.1NP_001352931.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1 and 2, encodes isoform 1.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  8. NM_001366003.1NP_001352932.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 6 and 10, encodes isoform 5.
    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  9. NM_001366004.1NP_001352933.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 6 and 9, encodes isoform 5.
    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  10. NM_001366005.1NP_001352934.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform 7.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  11. NM_001366006.1NP_001352935.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform 7.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  12. NM_001366007.1NP_001352936.1  adhesion G protein-coupled receptor L2 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191227
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:851875
    7tmB2_Latrophilin-2; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481120
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  13. NM_001366008.1NP_001352937.1  adhesion G protein-coupled receptor L2 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041212
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  14. NM_001366009.1NP_001352938.1  adhesion G protein-coupled receptor L2 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705, CA944538
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001175
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:847871
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8441101
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. NM_012302.4NP_036434.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC113949, AF104939, AJ131581, AL358939, AW008295, BM983870, CA429938
    Consensus CDS
    CCDS689.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000322270.6, OTTHUMP00000011444, ENST00000319517.10
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    81306104..81993932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454350.1XP_024310118.1  adhesion G protein-coupled receptor L2 isoform X2

    Related
    ENSP00000359760.1, ENST00000370725.5
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  2. XM_024454352.1XP_024310120.1  adhesion G protein-coupled receptor L2 isoform X2

    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  3. XM_024454355.1XP_024310123.1  adhesion G protein-coupled receptor L2 isoform X5

    Related
    ENSP00000359765.1, ENST00000370730.5
    Conserved Domains (7) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8441101
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  4. XM_017000789.2XP_016856278.1  adhesion G protein-coupled receptor L2 isoform X4

    Related
    ENSP00000359758.1, OTTHUMP00000011451, ENST00000370723.5
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    COG1266
    Location:9001074
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871446
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  5. XM_024454359.1XP_024310127.1  adhesion G protein-coupled receptor L2 isoform X9

    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871153
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:834858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_017000797.2XP_016856286.1  adhesion G protein-coupled receptor L2 isoform X8

  7. XM_024454358.1XP_024310126.1  adhesion G protein-coupled receptor L2 isoform X6

    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041212
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:851875
    7tmB2_Latrophilin-2; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481105
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  8. XM_005270668.2XP_005270725.1  adhesion G protein-coupled receptor L2 isoform X4

    See identical proteins and their annotated locations for XP_005270725.1

    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    COG1266
    Location:9001074
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871446
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  9. XM_017000784.1XP_016856273.1  adhesion G protein-coupled receptor L2 isoform X1

    Related
    ENSP00000397740.1, ENST00000449420.5
    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  10. XM_017000786.1XP_016856275.1  adhesion G protein-coupled receptor L2 isoform X2

    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  11. XM_006710489.3XP_006710552.1  adhesion G protein-coupled receptor L2 isoform X1

    See identical proteins and their annotated locations for XP_006710552.1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  12. XM_006710488.2XP_006710551.1  adhesion G protein-coupled receptor L2 isoform X1

    See identical proteins and their annotated locations for XP_006710551.1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  13. XM_024454357.1XP_024310125.1  adhesion G protein-coupled receptor L2 isoform X6

    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041212
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:851875
    7tmB2_Latrophilin-2; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481105
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  14. XM_017000796.1XP_016856285.1  adhesion G protein-coupled receptor L2 isoform X7

    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001175
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:847871
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8441101
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. XM_006710485.3XP_006710548.1  adhesion G protein-coupled receptor L2 isoform X1

    See identical proteins and their annotated locations for XP_006710548.1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  16. XM_005270666.4XP_005270723.1  adhesion G protein-coupled receptor L2 isoform X3

    See identical proteins and their annotated locations for XP_005270723.1

    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000359752.3, ENST00000370717.6
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    COG1266
    Location:9131087
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8451080
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001459
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539758
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
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