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ADGRL2 adhesion G protein-coupled receptor L2 [ Homo sapiens (human) ]

Gene ID: 23266, updated on 4-Nov-2022

Summary

Official Symbol
ADGRL2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L2provided by HGNC
Primary source
HGNC:HGNC:18582
See related
Ensembl:ENSG00000117114 MIM:607018; AllianceGenome:HGNC:18582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL2; LEC1; CIRL2; LPHH1; LPHN2
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in thyroid (RPKM 16.1), lung (RPKM 14.8) and 23 other tissues See more
Orthologs
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Genomic context

See ADGRL2 in Genome Data Viewer
Location:
1p31.1
Exon count:
41
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (81306132..81993932)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (81143677..81831513)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (81771817..82459616)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985018 Neighboring gene RN7SK pseudogene 247 Neighboring gene Sharpr-MPRA regulatory region 14351 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 8606 Neighboring gene uncharacterized LOC101927434 Neighboring gene ARID3B pseudogene 1 Neighboring gene ribosomal protein S20 pseudogene 7 Neighboring gene ST13, Hsp70 interacting protein pseudogene 20 Neighboring gene uncharacterized LOC124904204 Neighboring gene uncharacterized LOC105378814

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
UGT1A1 is a major locus influencing bilirubin levels in African Americans.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables latrotoxin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor L2
Names
calcium-independent alpha-latrotoxin receptor 2
latrophilin homolog 1
latrophilin-2
lectomedin-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297704.3NP_001284633.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Variants 1, 2, 8, 18, and 19 all encode the same isoform (1).
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS689.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000353006.2, ENST00000359929.7
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  2. NM_001297705.3NP_001284634.1  adhesion G protein-coupled receptor L2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 5. The encoded isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS72811.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000359750.1, ENST00000370715.5
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871162
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  3. NM_001297706.3NP_001284635.1  adhesion G protein-coupled receptor L2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001284635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons compared to variant 5. The encoded isoform (3) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS76174.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000359748.1, ENST00000370713.5
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871120
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  4. NM_001330645.3NP_001317574.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 17, encodes isoform 4.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS81345.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000501462.1, ENST00000674419.1
    Conserved Domains (7) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8441101
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  5. NM_001350698.2NP_001337627.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 9, 10, and 16, encodes isoform 5.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  6. NM_001350699.2NP_001337628.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 21, encodes isoform 6.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS90990.1
    UniProtKB/TrEMBL
    A0A6I8PIV6
    Related
    ENSP00000501484.1, ENST00000674442.1
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871162
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:833858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. NM_001366002.2NP_001352931.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 18, and 19, encodes isoform 1.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS689.1
    Related
    ENSP00000501431.1, ENST00000674393.1
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  8. NM_001366003.2NP_001352932.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 6, 10 and 16, encodes isoform 5.
    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  9. NM_001366004.2NP_001352933.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 6, 9, and 16, encodes isoform 5.
    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  10. NM_001366005.2NP_001352934.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform 7.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS90986.1
    UniProtKB/TrEMBL
    A0A8I5KUX3
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  11. NM_001366006.2NP_001352935.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform 7.
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS90986.1
    UniProtKB/TrEMBL
    A0A8I5KUX3
    Related
    ENSP00000509478.1, ENST00000686636.1
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  12. NM_001366007.2NP_001352936.1  adhesion G protein-coupled receptor L2 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Related
    ENSP00000501543.1, ENST00000674489.1
    Conserved Domains (8) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11191227
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:851875
    7tmB2_Latrophilin-2; TM helix 1 [structural motif]
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
    cl28897
    Location:8481120
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  13. NM_001366008.2NP_001352937.1  adhesion G protein-coupled receptor L2 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041212
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  14. NM_001366009.2NP_001352938.1  adhesion G protein-coupled receptor L2 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS90988.1
    UniProtKB/TrEMBL
    A0A6I8PLG0
    Related
    ENSP00000501532.1, ENST00000674208.1
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001175
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:847871
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8441101
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. NM_001393349.1NP_001380278.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
    Related
    ENSP00000359760.1, ENST00000370725.5
    Conserved Domains (7) summary
    smart00303
    Location:788840
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:469533
    HormR; Domain present in hormone receptors
    cd16006
    Location:8481105
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11041463
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:542764
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142398
    OLF; Olfactomedin-like domain
  16. NM_001393350.1NP_001380279.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS81345.1
    Conserved Domains (7) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8441101
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  17. NM_001393351.1NP_001380280.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS689.1
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  18. NM_001393352.1NP_001380281.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS689.1
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  19. NM_001393353.1NP_001380282.1  adhesion G protein-coupled receptor L2 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871162
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:833858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  20. NM_001393354.1NP_001380283.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS90990.1
    UniProtKB/TrEMBL
    A0A6I8PIV6
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871162
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:833858
    7tm_GPCRs; TM helix 1 [structural motif]
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
    cl28897
    Location:8311088
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  21. NM_012302.5NP_036434.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Variants 1, 2, 8, 18, and 19 all encode the same isoform (1).
    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705
    Consensus CDS
    CCDS689.1
    UniProtKB/Swiss-Prot
    O95490
    Related
    ENSP00000322270.6, ENST00000319517.10
    Conserved Domains (7) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8311088
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871403
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538747
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain

RNA

  1. NR_171658.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC113949, AL157903, AL358939, AL359705

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    81306132..81993932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416152.1XP_047272108.1  adhesion G protein-coupled receptor L2 isoform X6

    UniProtKB/TrEMBL
    A0A6I8PLG0
  2. XM_047416118.1XP_047272074.1  adhesion G protein-coupled receptor L2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8PTT2
    Related
    ENSP00000359758.1, ENST00000370723.5
  3. XM_047416159.1XP_047272115.1  adhesion G protein-coupled receptor L2 isoform X7

  4. XM_047416140.1XP_047272096.1  adhesion G protein-coupled receptor L2 isoform X5

  5. XM_047416096.1XP_047272052.1  adhesion G protein-coupled receptor L2 isoform X1

  6. XM_024454355.2XP_024310123.1  adhesion G protein-coupled receptor L2 isoform X4

    Related
    ENSP00000359765.1, ENST00000370730.5
    Conserved Domains (7) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    cd16006
    Location:8441101
    7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001416
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:538760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  7. XM_047416129.1XP_047272085.1  adhesion G protein-coupled receptor L2 isoform X4

  8. XM_047416124.1XP_047272080.1  adhesion G protein-coupled receptor L2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8PTT2
  9. XM_047416170.1XP_047272126.1  adhesion G protein-coupled receptor L2 isoform X7

  10. XM_047416146.1XP_047272102.1  adhesion G protein-coupled receptor L2 isoform X5

  11. XM_017000784.2XP_016856273.1  adhesion G protein-coupled receptor L2 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  12. XM_047416105.1XP_047272061.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UKY6
    Related
    ENSP00000359752.3, ENST00000370717.6
  13. XM_005270668.3XP_005270725.1  adhesion G protein-coupled receptor L2 isoform X3

    See identical proteins and their annotated locations for XP_005270725.1

    UniProtKB/TrEMBL
    A0A6I8PTT2
    Related
    ENSP00000501324.1, ENST00000674209.1
    Conserved Domains (8) summary
    smart00303
    Location:771823
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    COG1266
    Location:9001074
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8321067
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:10871446
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539745
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  14. XM_047416176.1XP_047272132.1  adhesion G protein-coupled receptor L2 isoform X7

  15. XM_047416098.1XP_047272054.1  adhesion G protein-coupled receptor L2 isoform X1

  16. XM_047416104.1XP_047272060.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UKY6
  17. XM_047416132.1XP_047272088.1  adhesion G protein-coupled receptor L2 isoform X4

  18. XM_047416126.1XP_047272082.1  adhesion G protein-coupled receptor L2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8PTT2
  19. XM_047416180.1XP_047272136.1  adhesion G protein-coupled receptor L2 isoform X7

  20. XM_006710489.4XP_006710552.1  adhesion G protein-coupled receptor L2 isoform X1

    See identical proteins and their annotated locations for XP_006710552.1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  21. XM_047416115.1XP_047272071.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UKY6
  22. XM_047416156.1XP_047272112.1  adhesion G protein-coupled receptor L2 isoform X6

    UniProtKB/TrEMBL
    A0A6I8PLG0
  23. XM_006710488.3XP_006710551.1  adhesion G protein-coupled receptor L2 isoform X1

    See identical proteins and their annotated locations for XP_006710551.1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  24. XM_047416102.1XP_047272058.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UKY6
  25. XM_047416121.1XP_047272077.1  adhesion G protein-coupled receptor L2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8PTT2
  26. XM_006710485.4XP_006710548.1  adhesion G protein-coupled receptor L2 isoform X1

    See identical proteins and their annotated locations for XP_006710548.1

    Conserved Domains (8) summary
    smart00303
    Location:789841
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:470534
    HormR; Domain present in hormone receptors
    COG1266
    Location:9181092
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8501085
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11051464
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143399
    OLF; Olfactomedin-like domain
  27. XM_005270666.5XP_005270723.1  adhesion G protein-coupled receptor L2 isoform X2

    See identical proteins and their annotated locations for XP_005270723.1

    UniProtKB/Swiss-Prot
    O95490, Q9UKY6
    Conserved Domains (8) summary
    smart00303
    Location:784836
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:465529
    HormR; Domain present in hormone receptors
    COG1266
    Location:9131087
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam00002
    Location:8451080
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:49129
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11001459
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:539758
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:138394
    OLF; Olfactomedin-like domain
  28. XM_047416128.1XP_047272084.1  adhesion G protein-coupled receptor L2 isoform X4

  29. XM_047416119.1XP_047272075.1  adhesion G protein-coupled receptor L2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8PTT2
  30. XM_047416164.1XP_047272120.1  adhesion G protein-coupled receptor L2 isoform X7

  31. XM_047416145.1XP_047272101.1  adhesion G protein-coupled receptor L2 isoform X5

  32. XM_047416092.1XP_047272048.1  adhesion G protein-coupled receptor L2 isoform X1

  33. XM_047416109.1XP_047272065.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UKY6
  34. XM_047416130.1XP_047272086.1  adhesion G protein-coupled receptor L2 isoform X4

  35. XM_047416120.1XP_047272076.1  adhesion G protein-coupled receptor L2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8PTT2
  36. XM_047416178.1XP_047272134.1  adhesion G protein-coupled receptor L2 isoform X7

  37. XM_047416150.1XP_047272106.1  adhesion G protein-coupled receptor L2 isoform X5

  38. XM_047416099.1XP_047272055.1  adhesion G protein-coupled receptor L2 isoform X1

  39. XM_047416110.1XP_047272066.1  adhesion G protein-coupled receptor L2 isoform X2

    UniProtKB/Swiss-Prot
    Q9UKY6
    Related
    ENSP00000359763.1, ENST00000370728.5
  40. XM_047416136.1XP_047272092.1  adhesion G protein-coupled receptor L2 isoform X4

  41. XM_047416148.1XP_047272104.1  adhesion G protein-coupled receptor L2 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    81143677..81831513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)