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EXOC7 exocyst complex component 7 [ Homo sapiens (human) ]

Gene ID: 23265, updated on 6-Jan-2019

Summary

Official Symbol
EXOC7provided by HGNC
Official Full Name
exocyst complex component 7provided by HGNC
Primary source
HGNC:HGNC:23214
See related
Ensembl:ENSG00000182473 MIM:608163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLOM4; EX070; EXO70; EXOC1; 2-5-3p; Exo70p; YJL085W
Summary
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in prostate (RPKM 23.4), brain (RPKM 22.0) and 25 other tissues See more
Orthologs

Genomic context

See EXOC7 in Genome Data Viewer
Location:
17q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (76080993..76103787, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74077086..74099868, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene envoplakin Neighboring gene signal recognition particle 68 Neighboring gene galanin receptor 2 Neighboring gene zinc activated ion channel Neighboring gene microRNA 6868 Neighboring gene uncharacterized LOC101928447 Neighboring gene RNF157 antisense RNA 1 Neighboring gene forkhead box J1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CDC42 signaling events, organism-specific biosystem
    CDC42 signaling events
  • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
    Cargo trafficking to the periciliary membrane, organism-specific biosystemProteomic studies suggest that the cilium is home to approximately a thousand proteins, and has a unique protein and lipid make up relative to the bulk cytoplasm and plasma membrane (Pazour et al, 20...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin processing, organism-specific biosystem (from REACTOME)
    Insulin processing, organism-specific biosystemThe generation of insulin-containing secretory granules from proinsulin in the lumen of the endoplasmic reticulum (ER) can be described in 4 steps: formation of intramolecular disulfide bonds, format...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
    Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • VxPx cargo-targeting to cilium, organism-specific biosystem (from REACTOME)
    VxPx cargo-targeting to cilium, organism-specific biosystemA number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40965, FLJ46415, DKFZp686J04253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of entry of bacterium into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of macroautophagy TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
exocyst IEA
Inferred from Electronic Annotation
more info
 
growth cone membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exocyst complex component 7
Names
exocyst complex component Exo70

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030672.1 RefSeqGene

    Range
    5001..27795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001013839.4NP_001013861.1  exocyst complex component 7 isoform 1

    See identical proteins and their annotated locations for NP_001013861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB028990, AI653861, BC011045, BX647763
    Consensus CDS
    CCDS32738.1
    UniProtKB/Swiss-Prot
    Q9UPT5
    UniProtKB/TrEMBL
    Q63HP7
    Related
    ENSP00000468404.1, ENST00000589210.5
    Conserved Domains (1) summary
    pfam03081
    Location:319678
    Exo70; Exo70 exocyst complex subunit
  2. NM_001145297.3NP_001138769.1  exocyst complex component 7 isoform 4

    See identical proteins and their annotated locations for NP_001138769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate in-frame exon resulting in a longer protein (isoform 4) compared to isoform 1.
    Source sequence(s)
    AB028990, AI565863, AI653861, BC018466, BX647763
    Consensus CDS
    CCDS45782.1
    UniProtKB/Swiss-Prot
    Q9UPT5
    UniProtKB/TrEMBL
    Q63HP7
    Related
    ENSP00000334100.6, ENST00000335146.11
    Conserved Domains (1) summary
    pfam03081
    Location:370729
    Exo70; Exo70 exocyst complex subunit
  3. NM_001145298.3NP_001138770.1  exocyst complex component 7 isoform 5

    See identical proteins and their annotated locations for NP_001138770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) omits an in-frame coding exon and includes an alternate in-frame coding exon compared to variant 1. The predicted protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AB028990, AI565863, AI653861, BX647763, FJ457119
    Consensus CDS
    CCDS45781.1
    UniProtKB/Swiss-Prot
    Q9UPT5
    UniProtKB/TrEMBL
    Q63HP7
    Related
    ENSP00000404322.2, ENST00000411744.6
    Conserved Domains (1) summary
    pfam03081
    Location:311670
    Exo70; Exo70 exocyst complex subunit
  4. NM_001145299.3NP_001138771.1  exocyst complex component 7 isoform 6

    See identical proteins and their annotated locations for NP_001138771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate in-frame coding exon, compared to variant 1, resulting in a longer protein isoform (6).
    Source sequence(s)
    AB028990, AI565863, AI653861, BX647763, FJ457120
    Consensus CDS
    CCDS45783.1
    UniProtKB/Swiss-Prot
    Q9UPT5
    UniProtKB/TrEMBL
    Q63HP7
    Related
    ENSP00000489266.1, ENST00000634349.1
    Conserved Domains (1) summary
    pfam03081
    Location:342701
    Exo70; Exo70 exocyst complex subunit
  5. NM_001282313.1NP_001269242.1  exocyst complex component 7 isoform 3

    See identical proteins and their annotated locations for NP_001269242.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG, and the resulting isoform (3) has a shorter N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AB028990, AI565863, AI653861, AK295871, BX647763, DC319923
    Consensus CDS
    CCDS45784.1
    UniProtKB/Swiss-Prot
    Q9UPT5
    UniProtKB/TrEMBL
    B4DJ07, Q63HP7
    Related
    ENSP00000466682.1, ENST00000467929.6
    Conserved Domains (1) summary
    pfam03081
    Location:278650
    Exo70; Exo70 exocyst complex subunit
  6. NM_001282314.1NP_001269243.1  exocyst complex component 7 isoform 7

    See identical proteins and their annotated locations for NP_001269243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks several 3' exons but contains an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus compared with isoform 1.
    Source sequence(s)
    AA215645, BC029432, HY020675
    Consensus CDS
    CCDS74164.1
    UniProtKB/TrEMBL
    B5MCY9
    Related
    ENSP00000385066.3, ENST00000406660.4
  7. NM_015219.4NP_056034.2  exocyst complex component 7 isoform 2

    See identical proteins and their annotated locations for NP_056034.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB028990, AI565863, AI653861, AK023832, BX647763
    Consensus CDS
    CCDS11741.1
    UniProtKB/Swiss-Prot
    Q9UPT5
    UniProtKB/TrEMBL
    Q63HP7
    Related
    ENSP00000333806.4, ENST00000332065.9
    Conserved Domains (1) summary
    pfam03081
    Location:288647
    Exo70; Exo70 exocyst complex subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    76080993..76103787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721789.4XP_006721852.1  exocyst complex component 7 isoform X5

    See identical proteins and their annotated locations for XP_006721852.1

    Conserved Domains (1) summary
    pfam03081
    Location:288660
    Exo70; Exo70 exocyst complex subunit
  2. XM_006721788.4XP_006721851.1  exocyst complex component 7 isoform X4

    See identical proteins and their annotated locations for XP_006721851.1

    Conserved Domains (1) summary
    pfam03081
    Location:311683
    Exo70; Exo70 exocyst complex subunit
  3. XM_006721787.4XP_006721850.1  exocyst complex component 7 isoform X3

    See identical proteins and their annotated locations for XP_006721850.1

    Conserved Domains (1) summary
    pfam03081
    Location:319691
    Exo70; Exo70 exocyst complex subunit
  4. XM_024450668.1XP_024306436.1  exocyst complex component 7 isoform X1

    Conserved Domains (1) summary
    pfam03081
    Location:319610
    Exo70; Exo70 exocyst complex subunit
  5. XM_006721786.4XP_006721849.1  exocyst complex component 7 isoform X2

    See identical proteins and their annotated locations for XP_006721849.1

    Conserved Domains (1) summary
    pfam03081
    Location:342714
    Exo70; Exo70 exocyst complex subunit
  6. XM_024450670.1XP_024306438.1  exocyst complex component 7 isoform X7

    Conserved Domains (1) summary
    pfam03081
    Location:159531
    Exo70; Exo70 exocyst complex subunit
  7. XM_024450674.1XP_024306442.1  exocyst complex component 7 isoform X9

    Conserved Domains (1) summary
    pfam03081
    Location:159518
    Exo70; Exo70 exocyst complex subunit
  8. XM_024450672.1XP_024306440.1  exocyst complex component 7 isoform X7

    Conserved Domains (1) summary
    pfam03081
    Location:159531
    Exo70; Exo70 exocyst complex subunit
  9. XM_024450669.1XP_024306437.1  exocyst complex component 7 isoform X6

    Conserved Domains (1) summary
    pfam03081
    Location:41413
    Exo70; Exo70 exocyst complex subunit
  10. XM_017024397.1XP_016879886.1  exocyst complex component 7 isoform X8

  11. XM_024450673.1XP_024306441.1  exocyst complex component 7 isoform X7

    Conserved Domains (1) summary
    pfam03081
    Location:159531
    Exo70; Exo70 exocyst complex subunit

RNA

  1. XR_001752458.2 RNA Sequence

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