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EXOC7 exocyst complex component 7 [ Homo sapiens (human) ]

Gene ID: 23265, updated on 10-Oct-2024

Summary

Official Symbol
EXOC7provided by HGNC
Official Full Name
exocyst complex component 7provided by HGNC
Primary source
HGNC:HGNC:23214
See related
Ensembl:ENSG00000182473 MIM:608163; AllianceGenome:HGNC:23214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLOM4; EX070; EXO70; EXOC1; 2-5-3p; Exo70p; NEDSEBA; YJL085W
Summary
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in prostate (RPKM 23.4), brain (RPKM 22.0) and 25 other tissues See more
Orthologs
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Genomic context

See EXOC7 in Genome Data Viewer
Location:
17q25.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76081016..76103787, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76977586..77000348, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74077097..74099868, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene envoplakin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74022969-74023856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74030076-74030683 Neighboring gene Sharpr-MPRA regulatory region 345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74036239-74036940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74036941-74037642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9001 Neighboring gene signal recognition particle 68 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74067885-74068712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74068713-74069540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74070927-74071808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74072691-74073571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74075097-74076094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74076095-74077090 Neighboring gene MPRA-validated peak3003 silencer Neighboring gene galanin receptor 2 Neighboring gene zinc activated ion channel Neighboring gene microRNA 6868 Neighboring gene uncharacterized LOC101928447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74127821-74128482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74128483-74129142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133109-74133770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74133771-74134430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74135093-74135752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9005 Neighboring gene RNF157 antisense RNA 1 Neighboring gene forkhead box J1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ40965, FLJ46415, DKFZp686J04253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of exocyst NAS
Non-traceable Author Statement
more info
PubMed 
located_in growth cone membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exocyst complex component 7
Names
exocyst complex component Exo70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030672.1 RefSeqGene

    Range
    5001..27772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001013839.4NP_001013861.1  exocyst complex component 7 isoform 1

    See identical proteins and their annotated locations for NP_001013861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB028990, AI653861, BC011045, BX647763
    Consensus CDS
    CCDS32738.1
    UniProtKB/TrEMBL
    Q5G0E1
    Related
    ENSP00000468404.1, ENST00000589210.6
    Conserved Domains (1) summary
    pfam03081
    Location:319678
    Exo70; Exo70 exocyst complex subunit
  2. NM_001145297.4NP_001138769.1  exocyst complex component 7 isoform 4

    See identical proteins and their annotated locations for NP_001138769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate in-frame exon resulting in a longer protein (isoform 4) compared to isoform 1.
    Source sequence(s)
    AB028990, AI653861, BC018466, BX647763
    Consensus CDS
    CCDS45782.1
    UniProtKB/Swiss-Prot
    B5MC69, B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32, Q9UPT5
    UniProtKB/TrEMBL
    Q5G0E1
    Related
    ENSP00000334100.6, ENST00000335146.11
    Conserved Domains (1) summary
    pfam03081
    Location:370729
    Exo70; Exo70 exocyst complex subunit
  3. NM_001145298.4NP_001138770.1  exocyst complex component 7 isoform 5

    See identical proteins and their annotated locations for NP_001138770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) omits an in-frame coding exon and includes an alternate in-frame coding exon compared to variant 1. The predicted protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AB028990, AI653861, BX647763, FJ457119
    Consensus CDS
    CCDS45781.1
    UniProtKB/TrEMBL
    Q5G0E1
    Related
    ENSP00000404322.2, ENST00000411744.6
    Conserved Domains (1) summary
    pfam03081
    Location:311670
    Exo70; Exo70 exocyst complex subunit
  4. NM_001145299.4NP_001138771.1  exocyst complex component 7 isoform 6

    See identical proteins and their annotated locations for NP_001138771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate in-frame coding exon, compared to variant 1, resulting in a longer protein isoform (6).
    Source sequence(s)
    AB028990, AI653861, BX647763, FJ457120
    Consensus CDS
    CCDS45783.1
    UniProtKB/TrEMBL
    Q5G0E1
    Related
    ENSP00000489266.1, ENST00000634349.1
    Conserved Domains (1) summary
    pfam03081
    Location:342701
    Exo70; Exo70 exocyst complex subunit
  5. NM_001282313.2NP_001269242.1  exocyst complex component 7 isoform 3

    See identical proteins and their annotated locations for NP_001269242.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG, and the resulting isoform (3) has a shorter N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AB028990, AI653861, AK295871, BX647763, DC319923
    Consensus CDS
    CCDS45784.1
    UniProtKB/TrEMBL
    B4DJ07, Q5G0E1
    Related
    ENSP00000466682.1, ENST00000467929.6
    Conserved Domains (1) summary
    pfam03081
    Location:278650
    Exo70; Exo70 exocyst complex subunit
  6. NM_001282314.2NP_001269243.1  exocyst complex component 7 isoform 7

    See identical proteins and their annotated locations for NP_001269243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks several 3' exons but contains an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus compared with isoform 1.
    Source sequence(s)
    AA215645, AC018665, BC029432, HY020675
    Consensus CDS
    CCDS74164.1
    UniProtKB/TrEMBL
    B5MCY9, K7ERQ5
    Related
    ENSP00000385066.3, ENST00000406660.4
  7. NM_001375974.1NP_001362903.1  exocyst complex component 7 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC018665
    UniProtKB/TrEMBL
    Q5G0E1
    Conserved Domains (1) summary
    pfam03081
    Location:313691
    Exo70; Exo70 exocyst complex subunit
  8. NM_001375975.1NP_001362904.1  exocyst complex component 7 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC018665
    UniProtKB/TrEMBL
    Q63HP7
    Conserved Domains (1) summary
    pfam03081
    Location:282660
    Exo70; Exo70 exocyst complex subunit
  9. NM_001375976.1NP_001362905.1  exocyst complex component 7 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC018665
    UniProtKB/TrEMBL
    Q5G0E1
    Conserved Domains (1) summary
    pfam03081
    Location:336714
    Exo70; Exo70 exocyst complex subunit
  10. NM_015219.5NP_056034.2  exocyst complex component 7 isoform 2

    See identical proteins and their annotated locations for NP_056034.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB028990, AI653861, AK023832, BX647763
    Consensus CDS
    CCDS11741.1
    UniProtKB/TrEMBL
    Q63HP7
    Related
    ENSP00000333806.4, ENST00000332065.9
    Conserved Domains (1) summary
    pfam03081
    Location:288647
    Exo70; Exo70 exocyst complex subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    76081016..76103787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721788.5XP_006721851.1  exocyst complex component 7 isoform X1

    See identical proteins and their annotated locations for XP_006721851.1

    UniProtKB/TrEMBL
    Q5G0E1
    Conserved Domains (1) summary
    pfam03081
    Location:311683
    Exo70; Exo70 exocyst complex subunit
  2. XM_047435690.1XP_047291646.1  exocyst complex component 7 isoform X2

  3. XM_047435691.1XP_047291647.1  exocyst complex component 7 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76977586..77000348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315596.1XP_054171571.1  exocyst complex component 7 isoform X1

  2. XM_054315597.1XP_054171572.1  exocyst complex component 7 isoform X2

  3. XM_054315598.1XP_054171573.1  exocyst complex component 7 isoform X3