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ZC3H7B zinc finger CCCH-type containing 7B [ Homo sapiens (human) ]

Gene ID: 23264, updated on 11-Jun-2025
Official Symbol
ZC3H7Bprovided by HGNC
Official Full Name
zinc finger CCCH-type containing 7Bprovided by HGNC
Primary source
HGNC:HGNC:30869
See related
Ensembl:ENSG00000100403 MIM:618206; AllianceGenome:HGNC:30869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RoXaN; ROXAN1
Summary
This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 25.2), ovary (RPKM 25.2) and 25 other tissues See more
Orthologs
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See ZC3H7B in Genome Data Viewer
Location:
22q13.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (41301525..41360147)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41780357..41838975)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41697529..41756151)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41632734-41633322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41633323-41633911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41633912-41634500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41634501-41635088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41636538-41637038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41637039-41637539 Neighboring gene chondroadherin like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41652381-41652924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41652925-41653468 Neighboring gene Ran GTPase activating protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41654013-41654555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41660124-41660999 Neighboring gene microRNA 6889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41667991-41668491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19112 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41685594-41686193 Neighboring gene Sharpr-MPRA regulatory region 14092 Neighboring gene Sharpr-MPRA regulatory region 10804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13783 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41697637-41698138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41704361-41704862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:41704863-41705362 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:41720150-41720650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41756000-41756522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41756523-41757045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41760009-41760569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13785 Neighboring gene uncharacterized LOC100996598 Neighboring gene uncharacterized LOC105373042 Neighboring gene RNA, U6 small nuclear 495, pseudogene Neighboring gene TEF transcription factor, PAR bZIP family member

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of zinc finger CCCH-type containing 7B (ZC3H7B) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ13787, KIAA1031, DKFZp434K0920

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables miRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in miRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-transcriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger CCCH domain-containing protein 7B
Names
Rotavirus 'X' associated non-structural protein
rotavirus 'X'-associated non-structural protein
rotavirus X protein associated with NSP3
ubiquitous tetratricopeptide containing protein RoXaN

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017590.6NP_060060.3  zinc finger CCCH domain-containing protein 7B

    See identical proteins and their annotated locations for NP_060060.3

    Status: REVIEWED

    Source sequence(s)
    AL035659
    Consensus CDS
    CCDS14013.1
    UniProtKB/Swiss-Prot
    A7YY88, B2RCA4, Q5TFX9, Q8TBT9, Q9H8B6, Q9UGQ9, Q9UGR0, Q9UGR1, Q9UGR2, Q9UK03, Q9UPW9
    Related
    ENSP00000345793.4, ENST00000352645.5
    Conserved Domains (6) summary
    sd00020
    Location:844866
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00006
    Location:3964
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:83112
    TPR_1; Tetratricopeptide repeat
    pfam00642
    Location:890913
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam12171
    Location:844867
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13414
    Location:37112
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    41301525..41360147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007067960.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    41780357..41838975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325296.1XP_054181271.1  zinc finger CCCH domain-containing protein 7B isoform X1

RNA

  1. XR_008485372.1 RNA Sequence