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MCF2L MCF.2 cell line derived transforming sequence like [ Homo sapiens (human) ]

Gene ID: 23263, updated on 17-Jun-2019

Summary

Official Symbol
MCF2Lprovided by HGNC
Official Full Name
MCF.2 cell line derived transforming sequence likeprovided by HGNC
Primary source
HGNC:HGNC:14576
See related
Ensembl:ENSG00000126217 MIM:609499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBS; OST; ARHGEF14
Summary
This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in fat (RPKM 8.1), brain (RPKM 8.0) and 22 other tissues See more
Orthologs

Genomic context

See MCF2L in Genome Data Viewer
Location:
13q34
Exon count:
42
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (112894378..113099742)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113548692..113754053)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 11A Neighboring gene Sharpr-MPRA regulatory region 8271 Neighboring gene ATP11A antisense RNA 1 Neighboring gene MCF2L antisense RNA 1 Neighboring gene uncharacterized LOC107984591 Neighboring gene proline-rich extensin-like protein EPR1 Neighboring gene F10 antisense RNA 1 Neighboring gene coagulation factor VII Neighboring gene coagulation factor X

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A variant in MCF2L is associated with osteoarthritis.
NHGRI GWA Catalog
Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
NHGRI GWA Catalog
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of CDC42 activity, organism-specific biosystem
    Regulation of CDC42 activity
  • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RhoA activity, organism-specific biosystem
    Regulation of RhoA activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12122, KIAA0362

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide exchange factor DBS
Names
DBL's big sister
MCF2 transforming sequence-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112732.3NP_001106203.2  guanine nucleotide exchange factor DBS isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK295670, AL137002, AL356740, AW241629
    Consensus CDS
    CCDS45070.2
    UniProtKB/Swiss-Prot
    O15068
    Related
    ENSP00000440374.2, ENST00000535094.7
    Conserved Domains (6) summary
    cd11857
    Location:10291082
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:800914
    PH; PH domain
  2. NM_001320815.2NP_001307744.1  guanine nucleotide exchange factor DBS isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AK295047, AL137002, AL162454, AW241629, DA348090, DB476653
    UniProtKB/Swiss-Prot
    O15068
    Conserved Domains (6) summary
    cd11857
    Location:10521105
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798912
    PH; PH domain
  3. NM_001320816.2NP_001307745.1  guanine nucleotide exchange factor DBS isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (d) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AB116074, AK295047, AL137002, AW241629, DB276568
    UniProtKB/Swiss-Prot
    O15068
    Related
    ENSP00000397285.1, ENST00000421756.5
    Conserved Domains (6) summary
    cd11857
    Location:10331086
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:804918
    PH; PH domain
  4. NM_001320817.2NP_001307746.1  guanine nucleotide exchange factor DBS isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains differences in the both UTRs and both the 5' and 3' coding regions, compared to variant 1. The resulting isoform (e) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AK295047, BC020208, DB476653
    Consensus CDS
    CCDS81782.1
    UniProtKB/Swiss-Prot
    O15068
    Related
    ENSP00000364747.4, ENST00000375597.8
    Conserved Domains (4) summary
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  5. NM_001366644.2NP_001353573.1  guanine nucleotide exchange factor DBS isoform f

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL356740, AL596093
    Conserved Domains (5) summary
    cd11857
    Location:10001053
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
  6. NM_001366645.2NP_001353574.1  guanine nucleotide exchange factor DBS isoform g

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL596093
  7. NM_001366646.2NP_001353575.1  guanine nucleotide exchange factor DBS isoform h

    Status: REVIEWED

    Source sequence(s)
    AL137002, AL162454, AL596093
  8. NM_024979.4NP_079255.4  guanine nucleotide exchange factor DBS isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) with a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK295047, AL137002, AL162454, AW241629, DB476653
    Consensus CDS
    CCDS9527.3
    UniProtKB/Swiss-Prot
    O15068
    Related
    ENSP00000364754.3, ENST00000375604.6
    Conserved Domains (6) summary
    cd11857
    Location:10271080
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798912
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    112894378..113099742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537482.1XP_011535784.1  guanine nucleotide exchange factor DBS isoform X2

    See identical proteins and their annotated locations for XP_011535784.1

    Related
    ENSP00000364758.3, ENST00000375608.7
    Conserved Domains (6) summary
    cd11857
    Location:11151168
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:830944
    PH; PH domain
  2. XM_011537483.2XP_011535785.1  guanine nucleotide exchange factor DBS isoform X2

    See identical proteins and their annotated locations for XP_011535785.1

    Conserved Domains (6) summary
    cd11857
    Location:11151168
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:632809
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352563
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:816947
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:830944
    PH; PH domain
  3. XM_011537486.2XP_011535788.2  guanine nucleotide exchange factor DBS isoform X1

  4. XM_017020493.1XP_016875982.1  guanine nucleotide exchange factor DBS isoform X3

  5. XM_017020495.1XP_016875984.1  guanine nucleotide exchange factor DBS isoform X6

    Related
    ENSP00000380225.1, ENST00000397030.5
    Conserved Domains (6) summary
    cd11857
    Location:10861139
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:103248
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:659836
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:379590
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:843974
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:857971
    PH; PH domain
  6. XM_017020499.2XP_016875988.1  guanine nucleotide exchange factor DBS isoform X15

  7. XM_011537485.1XP_011535787.1  guanine nucleotide exchange factor DBS isoform X7

    Conserved Domains (6) summary
    cd11857
    Location:10851138
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:602779
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:786917
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:800914
    PH; PH domain
  8. XM_011537488.1XP_011535790.1  guanine nucleotide exchange factor DBS isoform X9

    Conserved Domains (6) summary
    cd11857
    Location:10671120
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:28173
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:584761
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:304491
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:768899
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:782896
    PH; PH domain
  9. XM_011537490.1XP_011535792.1  guanine nucleotide exchange factor DBS isoform X10

    Conserved Domains (6) summary
    cd11857
    Location:10561109
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:573750
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:757888
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:771885
    PH; PH domain
  10. XM_011537484.1XP_011535786.1  guanine nucleotide exchange factor DBS isoform X5

    Conserved Domains (6) summary
    cd11857
    Location:10891142
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:606783
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:790921
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:804918
    PH; PH domain
  11. XM_017020494.1XP_016875983.1  guanine nucleotide exchange factor DBS isoform X4

  12. XM_011537487.1XP_011535789.1  guanine nucleotide exchange factor DBS isoform X8

    Conserved Domains (6) summary
    cd11857
    Location:10831136
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:600777
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:784915
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:798912
    PH; PH domain
  13. XM_011537491.1XP_011535793.1  guanine nucleotide exchange factor DBS isoform X11

    Conserved Domains (6) summary
    cd11857
    Location:10471100
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:62153
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:564741
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:284471
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:748879
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    pfam00169
    Location:762876
    PH; PH domain
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