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Vwde von Willebrand factor D and EGF domains [ Mus musculus (house mouse) ]

Gene ID: 232585, updated on 21-Apr-2024

Summary

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Official Symbol
Vwdeprovided by MGI
Official Full Name
von Willebrand factor D and EGF domainsprovided by MGI
Primary source
MGI:MGI:2685313
See related
Ensembl:ENSMUSG00000079679 AllianceGenome:MGI:2685313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm467
Summary
Predicted to be located in extracellular region. Orthologous to human VWDE (von Willebrand factor D and EGF domains). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
6 A1; 6 5.64 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13156439..13224964, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13156440..13224965, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106B Neighboring gene STARR-seq mESC enhancer starr_15191 Neighboring gene predicted gene, 24985 Neighboring gene STARR-positive B cell enhancer mm9_chr6:13230982-13231283 Neighboring gene predicted gene 725 Neighboring gene STARR-seq mESC enhancer starr_15192 Neighboring gene RIKEN cDNA 1700016P04 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation. Iwata K, et al. J Cell Physiol, 2022 Mar. PMID 34957547
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation.
    Title: von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
von Willebrand factor D and EGF domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013757.2 → NP_001013779.2  von Willebrand factor D and EGF domain-containing protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001013779.2

    Status: PROVISIONAL

    Source sequence(s)
    AC158682, BC076621
    Consensus CDS
    CCDS51722.1
    UniProtKB/Swiss-Prot
    B9EKY3, Q6DFV8
    Related
    ENSMUSP00000058110.6, ENSMUST00000054530.7
    Conserved Domains (1) summary
    cl02516
    Location:436 → 588
    VWD; von Willebrand factor type D domain

  2. NM_001368871.1 → NP_001355800.1  von Willebrand factor D and EGF domain-containing protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158682
    Consensus CDS
    CCDS90028.1
    UniProtKB/TrEMBL
    A0A0N4SVZ4
    Related
    ENSMUSP00000145311.2, ENSMUST00000203074.3
    Conserved Domains (3) summary
    smart00179
    Location:1256 → 1294
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:1222 → 1254
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl02516
    Location:436 → 588
    VWD; von Willebrand factor type D domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    13156439..13224964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFV8.2 GenPept UniProtKB/Swiss-Prot:Q6DFV8

Gene LinkOut

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