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Amn1 antagonist of mitotic exit network 1 [ Mus musculus (house mouse) ]

Gene ID: 232566, updated on 8-Nov-2022

Summary

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Official Symbol
Amn1provided by MGI
Official Full Name
antagonist of mitotic exit network 1provided by MGI
Primary source
MGI:MGI:2442933
See related
Ensembl:ENSMUSG00000068250 AllianceGenome:MGI:2442933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A230083D09; 5830467E07Rik; C730024G19Rik
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in Sertoli cell and brain. Orthologous to human AMN1 (antagonist of mitotic exit network 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 5.0), CNS E18 (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Amn1 in Genome Data Viewer
Location:
6; 6 G3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149059075..149090210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149157261..149188712, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene predicted gene, 23462 Neighboring gene electron transfer flavoprotein beta subunit lysine methyltransferase Neighboring gene retroelement silencing factor 1 Neighboring gene predicted gene, 38930

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STUDIES ON THE INTERACTION OF VITAMIN B12: INTRINSIC FACTOR AND RECEPTORS. 3. CHEMICAL AND BIOLOGICAL PROPERTIES OF VITAMIN B12 COMBINING SUBSTANCES FROM THE STOMACH, SERUM, AND ASCITES FLUID OF THE MOUSE. COFFEY JW, et al. Arch Biochem Biophys, 1965 Apr. PMID 14321840
  2. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Fyfe JC, et al. Blood, 2004 Mar 1. PMID 14576052
  3. Fam208a orchestrates interaction protein network essential for early embryonic development and cell division. Gresakova V, et al. Exp Cell Res, 2019 Sep 1. PMID 31112734
  4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cobalamin transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in microvillus membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein AMN1 homolog
Names
antagonist of mitotic exit network 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113424.1 → NP_001106895.1  protein AMN1 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412
    Consensus CDS
    CCDS51961.1
    UniProtKB/Swiss-Prot
    B8JKV0
    UniProtKB/TrEMBL
    B8JKV0
    Related
    ENSMUSP00000107160.2, ENSMUST00000111535.8
    Conserved Domains (2) summary
    cd09293
    Location:37 → 257
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:63 → 86
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_001356344.1 → NP_001343273.1  protein AMN1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412
    Consensus CDS
    CCDS90142.1
    UniProtKB/TrEMBL
    B8JKU8
    Related
    ENSMUSP00000092957.4, ENSMUST00000095319.10
    Conserved Domains (2) summary
    sd00034
    Location:20 → 43
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:1 → 214
    AMN1; Antagonist of mitotic exit network protein 1

  3. NM_001381983.1 → NP_001368912.1  protein AMN1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412
    Conserved Domains (2) summary
    cd09293
    Location:29 → 249
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:55 → 78
    LRR_AMN1; leucine-rich repeat [structural motif]

RNA

  1. NR_153963.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks two exons in the 5' region compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding sequence found in variant 1.
    Source sequence(s)
    AC128664, AK038995
    Related
    ENSMUST00000150610.8

  2. NR_167758.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412

  3. NR_167759.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412

  4. NR_167760.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412

  5. NR_167761.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412

  6. NR_167762.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412

  7. NR_167763.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128664, AC132412

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    149059075..149090210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B8JKV0.1 GenPept UniProtKB/Swiss-Prot:B8JKV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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