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MTCL1 microtubule crosslinking factor 1 [ Homo sapiens (human) ]

Gene ID: 23255, updated on 7-Jun-2020

Summary

Official Symbol
MTCL1provided by HGNC
Official Full Name
microtubule crosslinking factor 1provided by HGNC
Primary source
HGNC:HGNC:29121
See related
Ensembl:ENSG00000168502 MIM:615766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOGA2; CCDC165; KIAA0802
Expression
Broad expression in testis (RPKM 4.1), gall bladder (RPKM 3.9) and 22 other tissues See more
Orthologs

Genomic context

See MTCL1 in Genome Data Viewer
Location:
18p11.22
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (8705556..8832778)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (8705659..8832776)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RAB12, member RAS oncogene family Neighboring gene TOMM20 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 10096 Neighboring gene gastric cancer associated transcript 2 Neighboring gene ribosomal protein S4X pseudogene 19 Neighboring gene NDUFV2 antisense RNA 1 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0802

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apicolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apicolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule bundle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle ISS
Inferred from Sequence or Structural Similarity
more info
 
midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule cross-linking factor 1
Names
PAR-1-interacting protein
SOGA family member 2
coiled-coil domain containing 165
coiled-coil domain-containing protein 165

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378205.1NP_001365134.1  microtubule cross-linking factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
    Related
    ENSP00000305027.11, ENST00000306329.15
  2. NM_001378206.1NP_001365135.1  microtubule cross-linking factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
  3. NM_001378207.1NP_001365136.1  microtubule cross-linking factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
  4. NM_015210.4NP_056025.2  microtubule cross-linking factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AB018345, AK131528, AP000864, AP001531
    Consensus CDS
    CCDS11841.1
    UniProtKB/Swiss-Prot
    Q9Y4B5
    Related
    ENSP00000352927.3, ENST00000359865.7
    Conserved Domains (3) summary
    pfam11365
    Location:141235
    DUF3166; Protein of unknown function (DUF3166)
    pfam13870
    Location:16179
    DUF4201; Domain of unknown function (DUF4201)
    pfam14818
    Location:9091031
    DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    8705556..8832778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451115.1XP_024306883.1  microtubule cross-linking factor 1 isoform X7

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9941118
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024451116.1XP_024306884.1  microtubule cross-linking factor 1 isoform X8

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9941118
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024451110.1XP_024306878.1  microtubule cross-linking factor 1 isoform X1

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9941118
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_011525640.3XP_011523942.2  microtubule cross-linking factor 1 isoform X4

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9941090
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_024451119.1XP_024306887.1  microtubule cross-linking factor 1 isoform X11

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9561080
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_024451120.1XP_024306888.1  microtubule cross-linking factor 1 isoform X14

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9561052
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  7. XM_024451117.1XP_024306885.1  microtubule cross-linking factor 1 isoform X9

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9561052
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_024451121.1XP_024306889.1  microtubule cross-linking factor 1 isoform X15

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9151039
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_024451113.1XP_024306881.1  microtubule cross-linking factor 1 isoform X5

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9561080
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_024451114.1XP_024306882.1  microtubule cross-linking factor 1 isoform X6

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9531077
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  11. XM_024451118.1XP_024306886.1  microtubule cross-linking factor 1 isoform X10

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9151039
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  12. XM_024451111.1XP_024306879.1  microtubule cross-linking factor 1 isoform X2

    Conserved Domains (3) summary
    pfam11365
    Location:187281
    SOGA; Protein SOGA
    pfam14818
    Location:9931117
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1342
    SMC_N; RecF/RecN/SMC N terminal domain
  13. XM_024451112.1XP_024306880.1  microtubule cross-linking factor 1 isoform X3

    Conserved Domains (3) summary
    pfam11365
    Location:162256
    SOGA; Protein SOGA
    pfam14818
    Location:9681092
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1317
    SMC_N; RecF/RecN/SMC N terminal domain
  14. XM_024451124.1XP_024306892.1  microtubule cross-linking factor 1 isoform X21

    Conserved Domains (3) summary
    pfam11365
    Location:188282
    SOGA; Protein SOGA
    pfam14818
    Location:9941118
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:1343
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_017025671.2XP_016881160.1  microtubule cross-linking factor 1 isoform X17

  16. XM_017025674.2XP_016881163.1  microtubule cross-linking factor 1 isoform X18

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  17. XM_017025672.1XP_016881161.1  microtubule cross-linking factor 1 isoform X18

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  18. XM_017025673.1XP_016881162.1  microtubule cross-linking factor 1 isoform X18

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  19. XM_017025675.1XP_016881164.1  microtubule cross-linking factor 1 isoform X19

  20. XM_024451122.1XP_024306890.1  microtubule cross-linking factor 1 isoform X18

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  21. XM_024451123.1XP_024306891.1  microtubule cross-linking factor 1 isoform X20

    Conserved Domains (3) summary
    pfam11365
    Location:141235
    SOGA; Protein SOGA
    pfam14818
    Location:9061030
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:15296
    SMC_N; RecF/RecN/SMC N terminal domain
  22. XM_024451127.1XP_024306895.1  microtubule cross-linking factor 1 isoform X23

    Related
    ENSP00000463465.1, ENST00000518815.1
    Conserved Domains (1) summary
    pfam14818
    Location:277373
    DUF4482; Domain of unknown function (DUF4482)
  23. XM_024451125.1XP_024306893.1  microtubule cross-linking factor 1 isoform X22

    Conserved Domains (2) summary
    pfam14818
    Location:277401
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:141325
    SMC_N; RecF/RecN/SMC N terminal domain
  24. XM_024451126.1XP_024306894.1  microtubule cross-linking factor 1 isoform X22

    Conserved Domains (2) summary
    pfam14818
    Location:277401
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:141325
    SMC_N; RecF/RecN/SMC N terminal domain
  25. XM_024451128.1XP_024306896.1  microtubule cross-linking factor 1 isoform X24

    Conserved Domains (2) summary
    pfam14818
    Location:239363
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:141289
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_002958167.1 RNA Sequence

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