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MTCL1 microtubule crosslinking factor 1 [ Homo sapiens (human) ]

Gene ID: 23255, updated on 4-Nov-2022

Summary

Official Symbol
MTCL1provided by HGNC
Official Full Name
microtubule crosslinking factor 1provided by HGNC
Primary source
HGNC:HGNC:29121
See related
Ensembl:ENSG00000168502 MIM:615766; AllianceGenome:HGNC:29121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOGA2; CCDC165; KIAA0802
Summary
Enables microtubule binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in midbody and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 4.1), gall bladder (RPKM 3.9) and 22 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See MTCL1 in Genome Data Viewer
Location:
18p11.22
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (8705556..8832778)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (8868615..8995758)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (8705554..8832776)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RAB12, member RAS oncogene family Neighboring gene TOMM20 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 10096 Neighboring gene gastric cancer associated transcript 2 Neighboring gene ribosomal protein S4X pseudogene 19 Neighboring gene uncharacterized LOC124904243

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0802

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in apicolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apicolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in lateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in microtubule bundle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule bundle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule cross-linking factor 1
Names
PAR-1-interacting protein
SOGA family member 2
coiled-coil domain containing 165
coiled-coil domain-containing protein 165

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378205.1NP_001365134.1  microtubule cross-linking factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
    Consensus CDS
    CCDS92432.1
    UniProtKB/Swiss-Prot
    Q8IWA9
    Related
    ENSP00000305027.11, ENST00000306329.16
    Conserved Domains (5) summary
    PHA03247
    Location:12326
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:350729
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:3921278
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11365
    Location:501595
    SOGA; Protein SOGA
    pfam14818
    Location:12281351
    DUF4482; Domain of unknown function (DUF4482)
  2. NM_001378206.1NP_001365135.1  microtubule cross-linking factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
    Conserved Domains (5) summary
    PHA03247
    Location:12326
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:350729
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:3921319
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11365
    Location:501595
    SOGA; Protein SOGA
    pfam14818
    Location:12691392
    DUF4482; Domain of unknown function (DUF4482)
  3. NM_001378207.1NP_001365136.1  microtubule cross-linking factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
    Consensus CDS
    CCDS92433.1
    UniProtKB/TrEMBL
    A0A8Q3SIW6
    Related
    ENSP00000512072.1, ENST00000695635.1
    Conserved Domains (5) summary
    PHA03247
    Location:12326
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:350729
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:3921278
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam11365
    Location:501595
    SOGA; Protein SOGA
    pfam14818
    Location:12281351
    DUF4482; Domain of unknown function (DUF4482)
  4. NM_001395220.1NP_001382149.1  microtubule cross-linking factor 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AP000864, AP001531
    Consensus CDS
    CCDS92434.1
    Related
    ENSP00000429556.1, ENST00000517570.5
    Conserved Domains (2) summary
    COG1196
    Location:15369
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:32918
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. NM_001395333.1NP_001382262.1  microtubule cross-linking factor 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6).
    Source sequence(s)
    AP000864, AP001531
    Consensus CDS
    CCDS92431.1
    UniProtKB/TrEMBL
    A0A8Q3WKN6
    Related
    ENSP00000512073.1, ENST00000695636.1
    Conserved Domains (3) summary
    PHA03247
    Location:12326
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:350729
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:3921319
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  6. NM_015210.4NP_056025.2  microtubule cross-linking factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AB018345, AK131528, AP000864, AP001531
    Consensus CDS
    CCDS11841.1
    UniProtKB/Swiss-Prot
    Q9Y4B5
    Related
    ENSP00000352927.3, ENST00000359865.7
    Conserved Domains (5) summary
    COG1196
    Location:15296
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:811959
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02463
    Location:1716
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam11365
    Location:141235
    SOGA; Protein SOGA
    pfam14818
    Location:9091032
    DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    8705556..8832778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451115.2XP_024306883.2  microtubule cross-linking factor 1 isoform X7

  2. XM_024451110.2XP_024306878.2  microtubule cross-linking factor 1 isoform X1

  3. XM_011525640.4XP_011523942.3  microtubule cross-linking factor 1 isoform X4

  4. XM_024451113.2XP_024306881.2  microtubule cross-linking factor 1 isoform X5

  5. XM_024451117.2XP_024306885.2  microtubule cross-linking factor 1 isoform X9

  6. XM_024451114.2XP_024306882.2  microtubule cross-linking factor 1 isoform X6

  7. XM_047437395.1XP_047293351.1  microtubule cross-linking factor 1 isoform X11

  8. XM_024451118.2XP_024306886.2  microtubule cross-linking factor 1 isoform X12

  9. XM_047437397.1XP_047293353.1  microtubule cross-linking factor 1 isoform X14

  10. XM_024451111.2XP_024306879.2  microtubule cross-linking factor 1 isoform X2

  11. XM_047437396.1XP_047293352.1  microtubule cross-linking factor 1 isoform X13

  12. XM_024451112.2XP_024306880.2  microtubule cross-linking factor 1 isoform X3

  13. XM_047437394.1XP_047293350.1  microtubule cross-linking factor 1 isoform X10

  14. XM_047437399.1XP_047293355.1  microtubule cross-linking factor 1 isoform X16

  15. XM_047437393.1XP_047293349.1  microtubule cross-linking factor 1 isoform X8

  16. XM_047437398.1XP_047293354.1  microtubule cross-linking factor 1 isoform X15

  17. XM_047437400.1XP_047293356.1  microtubule cross-linking factor 1 isoform X17

    UniProtKB/Swiss-Prot
    Q8IWA9
  18. XM_024451124.2XP_024306892.2  microtubule cross-linking factor 1 isoform X21

  19. XM_017025671.3XP_016881160.1  microtubule cross-linking factor 1 isoform X18

  20. XM_017025674.3XP_016881163.1  microtubule cross-linking factor 1 isoform X19

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  21. XM_017025672.2XP_016881161.1  microtubule cross-linking factor 1 isoform X19

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  22. XM_047437401.1XP_047293357.1  microtubule cross-linking factor 1 isoform X19

  23. XM_017025673.2XP_016881162.1  microtubule cross-linking factor 1 isoform X19

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  24. XM_024451122.2XP_024306890.1  microtubule cross-linking factor 1 isoform X19

    Conserved Domains (3) summary
    pfam11365
    Location:167261
    SOGA; Protein SOGA
    pfam14818
    Location:9731097
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:16395
    SMC_N; RecF/RecN/SMC N terminal domain
  25. XM_024451123.2XP_024306891.1  microtubule cross-linking factor 1 isoform X20

    Conserved Domains (3) summary
    pfam11365
    Location:141235
    SOGA; Protein SOGA
    pfam14818
    Location:9061030
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:15296
    SMC_N; RecF/RecN/SMC N terminal domain
  26. XM_024451125.2XP_024306893.1  microtubule cross-linking factor 1 isoform X22

    Conserved Domains (2) summary
    pfam14818
    Location:277401
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:141325
    SMC_N; RecF/RecN/SMC N terminal domain
  27. XM_024451126.2XP_024306894.1  microtubule cross-linking factor 1 isoform X22

    Conserved Domains (2) summary
    pfam14818
    Location:277401
    DUF4482; Domain of unknown function (DUF4482)
    cl25732
    Location:141325
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_002958167.2 RNA Sequence

  2. XR_007066128.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    8868615..8995758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)