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OTUD3 OTU deubiquitinase 3 [ Homo sapiens (human) ]

Gene ID: 23252, updated on 28-Nov-2021

Summary

Official Symbol
OTUD3provided by HGNC
Official Full Name
OTU deubiquitinase 3provided by HGNC
Primary source
HGNC:HGNC:29038
See related
Ensembl:ENSG00000169914 MIM:611758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA4
Expression
Broad expression in testis (RPKM 8.1), endometrium (RPKM 3.2) and 23 other tissues See more
Orthologs
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Genomic context

See OTUD3 in Genome Data Viewer
Location:
1p36.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (19881708..19912945)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20208888..20239438)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene ring finger protein 186 Neighboring gene uncharacterized LOC105376823 Neighboring gene phospholipase A2 group IIE Neighboring gene Sharpr-MPRA regulatory region 3300

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
GeneReviews: Not available
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
GeneReviews: Not available
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
GeneReviews: Not available
Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.
GeneReviews: Not available
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of OTU domain containing 3 (OTUD3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
enables thiol-dependent deubiquitinase IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables thiol-dependent deubiquitinase TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K27-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein K27-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K6-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein K6-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K6-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
OTU domain-containing protein 3
Names
OTU domain containing 3
NP_056022.1
XP_005245849.1
XP_005245850.1
XP_005245851.1
XP_024310088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015207.2NP_056022.1  OTU domain-containing protein 3

    See identical proteins and their annotated locations for NP_056022.1

    Status: VALIDATED

    Source sequence(s)
    AA829387, AB007928, CV573628
    Consensus CDS
    CCDS41279.1
    UniProtKB/Swiss-Prot
    Q5T2D3
    Related
    ENSP00000364261.3, ENST00000375120.4
    Conserved Domains (1) summary
    cl19932
    Location:71157
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    19881708..19912945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245793.4XP_005245850.1  OTU domain-containing protein 3 isoform X2

    Conserved Domains (2) summary
    pfam08561
    Location:69115
    Ribosomal_L37; Mitochondrial ribosomal protein L37
    cl19932
    Location:146232
    OTU; OTU-like cysteine protease
  2. XM_005245792.4XP_005245849.1  OTU domain-containing protein 3 isoform X1

    Conserved Domains (1) summary
    cl19932
    Location:146232
    OTU; OTU-like cysteine protease
  3. XM_024454320.1XP_024310088.1  OTU domain-containing protein 3 isoform X3

  4. XM_005245794.3XP_005245851.1  OTU domain-containing protein 3 isoform X4

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