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MINAR1 membrane integral NOTCH2 associated receptor 1 [ Homo sapiens (human) ]

Gene ID: 23251, updated on 6-Jun-2024

Summary

Official Symbol
MINAR1provided by HGNC
Official Full Name
membrane integral NOTCH2 associated receptor 1provided by HGNC
Primary source
HGNC:HGNC:29172
See related
Ensembl:ENSG00000169330 MIM:618054; AllianceGenome:HGNC:29172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBTOR; KIAA1024
Summary
Involved in several processes, including negative regulation of TOR signaling; negative regulation of angiogenesis; and negative regulation of protein ubiquitination. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 4.7), salivary gland (RPKM 0.6) and 1 other tissue See more
Orthologs
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Genomic context

See MINAR1 in Genome Data Viewer
Location:
15q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (79411400..79472304)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (77274741..77335653)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (79724678..79764646)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ANKRD34C antisense RNA 1 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:79574999-79575538 Neighboring gene ankyrin repeat domain 34C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6722 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:79621073-79622272 Neighboring gene transmembrane p24 trafficking protein 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:79665964-79666609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9932 Neighboring gene NANOG hESC enhancer GRCh37_chr15:79711103-79711636 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:79756173-79757372 Neighboring gene uncharacterized LOC105370918 Neighboring gene uncharacterized LOC105370919 Neighboring gene TFDP1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
major intrinsically disordered Notch2-binding receptor 1
Names
major intrinsically disordered Notch2-associated receptor 1
ubiquitination and mTOR signaling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015206.3NP_056021.1  major intrinsically disordered Notch2-binding receptor 1

    See identical proteins and their annotated locations for NP_056021.1

    Status: VALIDATED

    Source sequence(s)
    AC105231
    Consensus CDS
    CCDS32306.1
    UniProtKB/Swiss-Prot
    A7MD43, Q9UPX6
    UniProtKB/TrEMBL
    H0YNN7
    Related
    ENSP00000307461.3, ENST00000305428.8
    Conserved Domains (1) summary
    pfam06789
    Location:759914
    UPF0258; Uncharacterized protein family (UPF0258)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    79411400..79472304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022027.2XP_016877516.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A7MD43, Q9UPX6
    UniProtKB/TrEMBL
    H0YNN7
    Conserved Domains (1) summary
    pfam06789
    Location:759914
    UPF0258; Uncharacterized protein family (UPF0258)
  2. XM_011521392.2XP_011519694.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011519694.1

    UniProtKB/Swiss-Prot
    A7MD43, Q9UPX6
    UniProtKB/TrEMBL
    H0YNN7
    Conserved Domains (1) summary
    pfam06789
    Location:759914
    UPF0258; Uncharacterized protein family (UPF0258)
  3. XM_011521395.3XP_011519697.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011519697.1

    UniProtKB/Swiss-Prot
    A7MD43, Q9UPX6
    UniProtKB/TrEMBL
    H0YNN7
    Conserved Domains (1) summary
    pfam06789
    Location:759914
    UPF0258; Uncharacterized protein family (UPF0258)
  4. XM_011521396.3XP_011519698.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011519698.1

    UniProtKB/Swiss-Prot
    A7MD43, Q9UPX6
    UniProtKB/TrEMBL
    H0YNN7
    Conserved Domains (1) summary
    pfam06789
    Location:759914
    UPF0258; Uncharacterized protein family (UPF0258)
  5. XM_011521393.4XP_011519695.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011519695.1

    UniProtKB/Swiss-Prot
    A7MD43, Q9UPX6
    UniProtKB/TrEMBL
    H0YNN7
    Conserved Domains (1) summary
    pfam06789
    Location:759914
    UPF0258; Uncharacterized protein family (UPF0258)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    77274741..77335653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377565.1XP_054233540.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/TrEMBL
    H0YNN7
  2. XM_054377563.1XP_054233538.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/TrEMBL
    H0YNN7
  3. XM_054377564.1XP_054233539.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/TrEMBL
    H0YNN7
  4. XM_054377566.1XP_054233541.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/TrEMBL
    H0YNN7
  5. XM_054377567.1XP_054233542.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/TrEMBL
    H0YNN7
  6. XM_054377568.1XP_054233543.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

    UniProtKB/TrEMBL
    H0YNN7