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RPRD2 regulation of nuclear pre-mRNA domain containing 2 [ Homo sapiens (human) ]

Gene ID: 23248, updated on 5-Sep-2021

Summary

Official Symbol
RPRD2provided by HGNC
Official Full Name
regulation of nuclear pre-mRNA domain containing 2provided by HGNC
Primary source
HGNC:HGNC:29039
See related
Ensembl:ENSG00000163125 MIM:614695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC099; KIAA0460
Expression
Ubiquitous expression in thyroid (RPKM 11.1), ovary (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See RPRD2 in Genome Data Viewer
Location:
1q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (150364147..150476566)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150336623..150449042)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene pre-mRNA processing factor 3 Neighboring gene microRNA 6878 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial Neighboring gene extracellular matrix protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of regulation of nuclear pre-mRNA domain containing 2 (RPRD2 ) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of regulation of nuclear pre-mRNA domain containing 2 (RPRD2; KIAA0460) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32145, KIAA0460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II, holoenzyme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II, holoenzyme IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulation of nuclear pre-mRNA domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297673.2NP_001284602.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001284602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and lacks an alternate segment in 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA749025, AK304380, AL356356, BX284695, BX641025, HY021241
    UniProtKB/Swiss-Prot
    Q5VT52
    Conserved Domains (1) summary
    smart00582
    Location:27145
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
  2. NM_001297674.2NP_001284603.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001284603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA749025, AL356356, BC045623, BX641025, HY021241
    Consensus CDS
    CCDS72907.1
    UniProtKB/Swiss-Prot
    Q5VT52
    Related
    ENSP00000383785.4, ENST00000401000.8
    Conserved Domains (1) summary
    smart00582
    Location:27145
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
  3. NM_001387114.1NP_001374043.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    pfam05109
    Location:293573
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27145
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
    NF033930
    Location:96378
    pneumo_PspA; pneumococcal surface protein A
  4. NM_001387115.1NP_001374044.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    PHA03247
    Location:288561
    PHA03247; large tegument protein UL36; Provisional
    PRK03918
    Location:98292
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd17001
    Location:27145
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
  5. NM_001387116.1NP_001374045.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    PHA03247
    Location:314587
    PHA03247; large tegument protein UL36; Provisional
    PRK03918
    Location:142318
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd17001
    Location:27146
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
  6. NM_001387117.1NP_001374046.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    PRK03918
    Location:142318
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam05109
    Location:319636
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27146
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
  7. NM_001387118.1NP_001374047.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    PRK03918
    Location:98292
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam05109
    Location:293610
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27145
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
  8. NM_001387119.1NP_001374048.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    PRK03918
    Location:142318
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam05109
    Location:319636
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27146
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
  9. NM_001387120.1NP_001374049.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (3) summary
    PHA03247
    Location:314587
    PHA03247; large tegument protein UL36; Provisional
    PRK03918
    Location:142318
    PRK03918; DNA double-strand break repair ATPase Rad50
    cd17001
    Location:27146
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
  10. NM_001387121.1NP_001374050.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (1) summary
    pfam05109
    Location:103420
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  11. NM_001387122.1NP_001374051.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (2) summary
    PHA03247
    Location:178451
    PHA03247; large tegument protein UL36; Provisional
    PRK03918
    Location:6182
    PRK03918; DNA double-strand break repair ATPase Rad50
  12. NM_001387123.1NP_001374052.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (2) summary
    PHA03247
    Location:178451
    PHA03247; large tegument protein UL36; Provisional
    PRK03918
    Location:6182
    PRK03918; DNA double-strand break repair ATPase Rad50
  13. NM_001387124.1NP_001374053.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL356356, AL611942, BX284695
    Conserved Domains (2) summary
    PHA03247
    Location:178451
    PHA03247; large tegument protein UL36; Provisional
    PRK03918
    Location:6182
    PRK03918; DNA double-strand break repair ATPase Rad50
  14. NM_015203.5NP_056018.2  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056018.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA749025, AK291703, AL356356, BC045623, DB455925, HY021241
    Consensus CDS
    CCDS44216.1
    UniProtKB/Swiss-Prot
    Q5VT52
    Related
    ENSP00000358064.4, ENST00000369068.5
    Conserved Domains (1) summary
    smart00582
    Location:27145
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    150364147..150476566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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