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ANKRD28 ankyrin repeat domain 28 [ Homo sapiens (human) ]

Gene ID: 23243, updated on 9-Feb-2020

Summary

Official Symbol
ANKRD28provided by HGNC
Official Full Name
ankyrin repeat domain 28provided by HGNC
Primary source
HGNC:HGNC:29024
See related
Ensembl:ENSG00000206560 MIM:611122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PITK; FAP79; CFAP79; PPP1R65
Expression
Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See ANKRD28 in Genome Data Viewer
Location:
3p25.1
Exon count:
36
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (15667236..15859814, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15708743..15901053, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene RNA, 7SL, cytoplasmic 110, pseudogene Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene biotinidase Neighboring gene microRNA 3134 Neighboring gene uncharacterized LOC101927647 Neighboring gene RNA, 7SL, cytoplasmic 4, pseudogene Neighboring gene uncharacterized LOC107986064 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 8 Neighboring gene microRNA 563

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
Names
PP6-ARS-A
ankyrin repeat domain-containing protein 28
phosphatase interactor targeting K protein
phosphatase interactor targeting protein hnRNP K
protein phosphatase 1, regulatory subunit 65
protein phosphatase 6 ankyrin repeat subunit A
serine/threonine-protein phosphatase 6 regulatory subunit ARS-A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195098.1NP_001182027.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b

    See identical proteins and their annotated locations for NP_001182027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 10, encodes isoform b.
    Source sequence(s)
    AC090950, AK293770, AY367056, BQ423818
    Consensus CDS
    CCDS74908.1
    UniProtKB/Swiss-Prot
    O15084
    Related
    ENSP00000485421.1, ENST00000624145.3
    Conserved Domains (6) summary
    cd00204
    Location:13138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:2249
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:288372
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:774825
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:385436
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:65321
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001195099.2NP_001182028.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b

    See identical proteins and their annotated locations for NP_001182028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 10, encodes isoform b.
    Source sequence(s)
    AC090950, AK293770, AY367056, BQ423818
    Consensus CDS
    CCDS74908.1
    UniProtKB/Swiss-Prot
    O15084
    Conserved Domains (6) summary
    cd00204
    Location:13138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:2249
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:288372
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:774825
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:385436
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:65321
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001349277.2NP_001336206.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform c.
    Source sequence(s)
    AC090950
    Conserved Domains (6) summary
    cd00204
    Location:680809
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:173203
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:475559
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:9611012
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:572623
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:55343
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_001349278.2NP_001336207.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform d.
    Source sequence(s)
    AC090950
    Conserved Domains (6) summary
    cd00204
    Location:677806
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:170200
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:472556
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:9581009
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:569620
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:52340
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_001349279.2NP_001336208.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform e.
    Source sequence(s)
    AC090945, AC090950
    Conserved Domains (6) summary
    cd00204
    Location:644773
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:137167
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:439523
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:925976
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:536587
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:19307
    Ank_2; Ankyrin repeats (3 copies)
  6. NM_001349280.1NP_001336209.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform f.
    Source sequence(s)
    AC090950
    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  7. NM_001349281.2NP_001336210.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform f.
    Source sequence(s)
    AC090950
    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  8. NM_001349282.2NP_001336211.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform f.
    Source sequence(s)
    AC090950
    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  9. NM_001349283.2NP_001336212.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC090950
    Consensus CDS
    CCDS74908.1
    Conserved Domains (6) summary
    cd00204
    Location:13138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:2249
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:288372
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:774825
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:385436
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:65321
    Ank_2; Ankyrin repeats (3 copies)
  10. NM_001349284.2NP_001336213.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) encodes isoform g.
    Source sequence(s)
    AC090950
  11. NM_001349285.2NP_001336214.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes isoform h.
    Source sequence(s)
    AC090950
  12. NM_015199.4NP_056014.2  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform a

    See identical proteins and their annotated locations for NP_056014.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC090945, AC090950, AI565587, AK293770, AY367056, BQ423818, CN313636
    Consensus CDS
    CCDS46769.1
    UniProtKB/Swiss-Prot
    O15084
    UniProtKB/TrEMBL
    A0A024R2G8
    Related
    ENSP00000382379.2, ENST00000399451.6
    Conserved Domains (6) summary
    cd00204
    Location:647776
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:140170
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:442526
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:928979
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:539590
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:22310
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_146111.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090950
  2. NR_146112.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090950

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    15667236..15859814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453418.1XP_024309186.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1

    Conserved Domains (6) summary
    cd00204
    Location:661790
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:154184
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:456540
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:942993
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:553604
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:36324
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_011533542.3XP_011531844.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X5

    See identical proteins and their annotated locations for XP_011531844.1

    Conserved Domains (6) summary
    cd00204
    Location:619748
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:112142
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:414498
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:900951
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:511562
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:6273
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_024453419.1XP_024309187.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X2

    Conserved Domains (6) summary
    cd00204
    Location:658787
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:151181
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:453537
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:939990
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:550601
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:33321
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_024453420.1XP_024309188.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X4

    Conserved Domains (5) summary
    cd00204
    Location:594723
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:123150
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:322363
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:486537
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:36306
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_024453422.1XP_024309190.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_024453424.1XP_024309192.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_011533547.3XP_011531849.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

    See identical proteins and their annotated locations for XP_011531849.1

    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  8. XM_024453421.1XP_024309189.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  9. XM_024453423.1XP_024309191.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X6

    Conserved Domains (5) summary
    cd00204
    Location:78203
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:84114
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:319360
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:483534
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:30303
    Ank_2; Ankyrin repeats (3 copies)
  10. XM_017006029.1XP_016861518.1  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X7

  11. XM_011533541.3XP_011531843.2  serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3

    Conserved Domains (5) summary
    cd00204
    Location:661790
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:154184
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:456540
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:553604
    Ank_5; Ankyrin repeats (many copies)
    cl26073
    Location:36324
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_002959503.1 RNA Sequence

  2. XR_001740071.2 RNA Sequence

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