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Clec12a C-type lectin domain family 12, member a [ Mus musculus (house mouse) ]

Gene ID: 232413, updated on 24-Sep-2025
Official Symbol
Clec12aprovided by MGI
Official Full Name
C-type lectin domain family 12, member aprovided by MGI
Primary source
MGI:MGI:3040968
See related
Ensembl:ENSMUSG00000053063 AllianceGenome:MGI:3040968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Micl; CLL-1; KLRL1; mMICL; mKLRL1; D230024O04
Summary
Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including negative regulation of dendritic cell differentiation; negative regulation of leukocyte activation; and positive regulation of type I interferon production. Is active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in liver E18 (RPKM 6.7), liver E14 (RPKM 4.0) and 10 other tissues See more
Orthologs
human all
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See Clec12a in Genome Data Viewer
Location:
6 F3; 6 63.26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129327207..129342266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129349783..129365303)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6497 Neighboring gene STARR-positive B cell enhancer ABC_E1329 Neighboring gene STARR-positive B cell enhancer ABC_E11735 Neighboring gene STARR-positive B cell enhancer ABC_E1330 Neighboring gene CD69 antigen Neighboring gene STARR-positive B cell enhancer ABC_E3684 Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene STARR-positive B cell enhancer ABC_E6498 Neighboring gene C-type lectin domain family 12, member B Neighboring gene STARR-positive B cell enhancer ABC_E4872 Neighboring gene C-type lectin domain family 1, member b Neighboring gene C-type lectin domain family 9, member a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals. Chiaro TR, et al. Cell Host Microbe, 2025 Jan 8. PMID 39788099,
  2. mKLRL1 regulates the maturation of dendritic cells and plays important roles in immune tolerance. Liu G, et al. Am J Transl Res, 2019. PMID 30787988, Free PMC Article
  3. Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity. Sagar D, et al. Sci Rep, 2017 Jun 2. PMID 28578388, Free PMC Article
  4. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Neumann K, et al. Immunity, 2014 Mar 20. PMID 24631154
  5. MICL controls inflammation in rheumatoid arthritis. Redelinghuys P, et al. Ann Rheum Dis, 2016 Jul. PMID 26275430, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recognition and control of neutrophil extracellular trap formation by MICL.
    Title: Recognition and control of neutrophil extracellular trap formation by MICL.
  2. Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.
    Title: Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.
  3. The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.
    Title: The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.
  4. Study observed that the uric acid crystal receptor Clec12A functions as a positive modulator of the IFN-I response, which amplifies nucleic acid-sensing pattern recognition receptors signals through the TBK1-IRF3 axis. Clec12a-/- mice exhibit increased susceptibility to acute lymphocytic choriomeningitis virus (LCMV) infection and improved virus clearance during chronic LCMV infection in vivo.
    Title: The uric acid crystal receptor Clec12A potentiates type I interferon responses.
  5. The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS.
    Title: Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
  6. Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting
    Title: Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.
  7. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo.
    Title: Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
  8. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
    Title: Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
  9. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia
    Title: The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.
  10. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent
    Title: The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (3)  1 citation

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pattern recognition receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables pattern recognition receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables signaling receptor regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of natural killer cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of natural killer cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neutrophil activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neutrophil activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neutrophil activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neutrophil activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of immune response ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
C-type lectin domain family 12 member A
Names
C-type lectin-like molecule 1
killer cell C-type lectin-like receptor L1
myeloid inhibitory C-type lectin-like receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177686.4 → NP_808354.1  C-type lectin domain family 12 member A

    See identical proteins and their annotated locations for NP_808354.1

    Status: VALIDATED

    Source sequence(s)
    AC138620, AK084335, BB850261
    Consensus CDS
    CCDS20584.1
    UniProtKB/Swiss-Prot
    Q504P2, Q8BN96
    UniProtKB/TrEMBL
    A0A0R4J0T2
    Related
    ENSMUSP00000063627.5, ENSMUST00000065289.6
    Conserved Domains (1) summary
    cd03593
    Location:133 → 247
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129327207..129342266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504P2.1 GenPept UniProtKB/Swiss-Prot:Q504P2

Gene LinkOut

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