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PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 23239, updated on 27-Nov-2024

Summary

Official Symbol
PHLPP1provided by HGNC
Official Full Name
PH domain and leucine rich repeat protein phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:20610
See related
Ensembl:ENSG00000081913 MIM:609396; AllianceGenome:HGNC:20610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCOP; PHLPP; PPM3A; PLEKHE1
Summary
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Expression
Broad expression in brain (RPKM 17.2), testis (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

See PHLPP1 in Genome Data Viewer
Location:
18q21.33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (62715541..62980433)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (62918332..63183249)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (60382774..60647666)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:60190967-60191540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13432 Neighboring gene Sharpr-MPRA regulatory region 3490 Neighboring gene zinc finger CCHC-type containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:60278845-60279519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13434 Neighboring gene RNA, 7SL, cytoplasmic 705, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_49084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9516 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:60383195-60384157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9520 Neighboring gene Sharpr-MPRA regulatory region 7810 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:60418194-60419090 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:60419091-60419986 Neighboring gene uncharacterized LOC105372160 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:60427134-60428104 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:60428105-60429074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13437 Neighboring gene RNA, U6 small nuclear 142, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:60539365-60539866 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:60544855-60545355 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:60546255-60546756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:60546757-60547256 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_49136 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:60565763-60566264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9521 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:60573152-60573764 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:60573765-60574376 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:60609220-60610419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13438 Neighboring gene Sharpr-MPRA regulatory region 4133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13439 Neighboring gene uncharacterized LOC105372161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13446 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:60805026-60805892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:60813108-60813608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:60813609-60814109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13462 Neighboring gene uncharacterized LOC124904379 Neighboring gene BCL2 apoptosis regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC161555

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PH domain leucine-rich repeat-containing protein phosphatase 1
Names
PH domain-containing family E member 1
SCN circadian oscillatory protein
pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
protein phosphatase, Mg2+/Mn2+ dependent 3A
suprachiasmatic nucleus circadian oscillatory protein
NP_919431.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031923.1 RefSeqGene

    Range
    5103..269995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_194449.4NP_919431.2  PH domain leucine-rich repeat-containing protein phosphatase 1

    See identical proteins and their annotated locations for NP_919431.2

    Status: REVIEWED

    Source sequence(s)
    AC015989, AC022046, AC027553, BC126277
    Consensus CDS
    CCDS45881.2
    UniProtKB/Swiss-Prot
    A1A4F5, O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1
    Related
    ENSP00000262719.4, ENST00000262719.10
    Conserved Domains (6) summary
    smart00332
    Location:11681420
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    cd00116
    Location:625929
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd13322
    Location:535631
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:833853
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00169
    Location:555636
    PH; PH domain
    pfam13855
    Location:10141072
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    62715541..62980433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    62918332..63183249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)