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PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 23239, updated on 6-Sep-2020

Summary

Official Symbol
PHLPP1provided by HGNC
Official Full Name
PH domain and leucine rich repeat protein phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:20610
See related
Ensembl:ENSG00000081913 MIM:609396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCOP; PHLPP; PPM3A; PLEKHE1
Summary
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Expression
Broad expression in brain (RPKM 17.2), testis (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See PHLPP1 in Genome Data Viewer
Location:
18q21.33
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (62715445..62980433)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (60382672..60647676)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 2 Neighboring gene RNA, 7SL, cytoplasmic 705, pseudogene Neighboring gene RNA, U6 small nuclear 142, pseudogene Neighboring gene uncharacterized LOC105372160 Neighboring gene Sharpr-MPRA regulatory region 4133 Neighboring gene uncharacterized LOC105372161

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC161555

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
entrainment of circadian clock IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of T cell anergy IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PH domain leucine-rich repeat-containing protein phosphatase 1
Names
PH domain-containing family E member 1
SCN circadian oscillatory protein
pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
protein phosphatase, Mg2+/Mn2+ dependent 3A
suprachiasmatic nucleus circadian oscillatory protein
NP_919431.2
XP_011524188.1
XP_024306873.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031923.1 RefSeqGene

    Range
    5103..269995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_194449.4NP_919431.2  PH domain leucine-rich repeat-containing protein phosphatase 1

    See identical proteins and their annotated locations for NP_919431.2

    Status: REVIEWED

    Source sequence(s)
    AC015989, AC022046, AC027553, BC126277
    Consensus CDS
    CCDS45881.2
    UniProtKB/Swiss-Prot
    O60346
    Related
    ENSP00000262719.4, ENST00000262719.10
    Conserved Domains (6) summary
    smart00332
    Location:11681420
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    cd00116
    Location:625929
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd13322
    Location:535631
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:833853
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00169
    Location:555636
    PH; PH domain
    pfam13855
    Location:10141072
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    62715445..62980433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525886.1XP_011524188.1  PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X2

    Conserved Domains (6) summary
    COG4886
    Location:6771051
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:625929
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd13322
    Location:535631
    PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
    sd00033
    Location:833853
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00169
    Location:555636
    PH; PH domain
    pfam13855
    Location:638703
    LRR_8; Leucine rich repeat
  2. XM_024451105.1XP_024306873.1  PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1

    Conserved Domains (4) summary
    smart00332
    Location:627879
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    sd00033
    Location:292312
    LRR_RI; leucine-rich repeat [structural motif]
    cl17171
    Location:190
    PH-like; Pleckstrin homology-like domain
    cl26793
    Location:98585
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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