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ARC activity regulated cytoskeleton associated protein [ Homo sapiens (human) ]

Gene ID: 23237, updated on 29-Mar-2020

Summary

Official Symbol
ARCprovided by HGNC
Official Full Name
activity regulated cytoskeleton associated proteinprovided by HGNC
Primary source
HGNC:HGNC:648
See related
Ensembl:ENSG00000198576 MIM:612461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hArc; Arg3.1
Expression
Biased expression in adrenal (RPKM 5.5), brain (RPKM 5.4) and 9 other tissues See more
Orthologs

Genomic context

See ARC in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (142611049..142614479, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143692405..143695833, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene maestro heat like repeat family member 4, pseudogene Neighboring gene uncharacterized LOC101928087 Neighboring gene Jrk helix-turn-helix protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0278

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine morphogenesis TAS
Traceable Author Statement
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
learning IEA
Inferred from Electronic Annotation
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory TAS
Traceable Author Statement
more info
PubMed 
long-term synaptic potentiation TAS
Traceable Author Statement
more info
PubMed 
mRNA transport ISS
Inferred from Sequence or Structural Similarity
more info
 
modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of AMPA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated intercellular transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
activity-regulated cytoskeleton-associated protein
Names
ARC/ARG3.1
activity-regulated gene 3.1 protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015193.5NP_056008.1  activity-regulated cytoskeleton-associated protein

    See identical proteins and their annotated locations for NP_056008.1

    Status: VALIDATED

    Source sequence(s)
    AP006547, BC012321
    Consensus CDS
    CCDS34950.1
    UniProtKB/Swiss-Prot
    Q7LC44
    Related
    ENSP00000349022.2, ENST00000356613.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    142611049..142614479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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