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SIK2 salt inducible kinase 2 [ Homo sapiens (human) ]

Gene ID: 23235, updated on 23-Nov-2021

Summary

Official Symbol
SIK2provided by HGNC
Official Full Name
salt inducible kinase 2provided by HGNC
Primary source
HGNC:HGNC:21680
See related
Ensembl:ENSG00000170145 MIM:608973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QIK; SIK-2; SNF1LK2; LOH11CR1I
Expression
Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues See more
Orthologs
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Genomic context

See SIK2 in Genome Data Viewer
Location:
11q23.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (111602449..111730855)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111473173..111601579)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene layilin Neighboring gene RN7SK pseudogene 273 Neighboring gene protein phosphatase 2 scaffold subunit Abeta Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene G protein subunit gamma 5 pseudogene 3 Neighboring gene ferredoxin-fold anticodon binding domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0781, DKFZp434K1115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase SIK2
Names
SNF1-like kinase 2
qin-induced kinase
salt-inducible protein kinase 2
salt-inducible serine/threonine kinase 2
serine/threonine-protein kinase SNF1-like kinase 2
NP_056006.1
XP_016872906.1
XP_016872907.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015191.3NP_056006.1  serine/threonine-protein kinase SIK2

    See identical proteins and their annotated locations for NP_056006.1

    Status: VALIDATED

    Source sequence(s)
    AP000925
    Consensus CDS
    CCDS8347.1
    UniProtKB/Swiss-Prot
    Q9H0K1
    UniProtKB/TrEMBL
    A0A024R3G7
    Related
    ENSP00000305976.3, ENST00000304987.4
    Conserved Domains (2) summary
    cd14409
    Location:297341
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cd14071
    Location:19271
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    111602449..111730855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017417.1XP_016872906.1  serine/threonine-protein kinase SIK2 isoform X1

  2. XM_017017418.1XP_016872907.1  serine/threonine-protein kinase SIK2 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:1118
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14409
    Location:144188
    UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
    cl21453
    Location:1118
    PKc_like; Protein Kinases, catalytic domain
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