SIK2 salt inducible kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIK2provided by HGNC
Official Full Name: salt inducible kinase 2provided by HGNC
Primary source: HGNC:HGNC:21680
See related: Ensembl:ENSG00000170145 MIM:608973; AllianceGenome:HGNC:21680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: QIK; SIK-2; SNF1LK2; LOH11CR1I
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 11q23.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (111602449..111730855)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (111612584..111741007)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (111473173..111601579)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Title: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes.
Title: Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes.
Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
Title: Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
Title: SIK2 protects against renal tubular injury and the progression of diabetic kidney disease.
SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
Title: SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK.
SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/beta-catenin signaling.
Title: SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling.
SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells.
Title: SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA-deficient cells.
LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression.
Title: LINC00662 facilitates osteosarcoma progression via sponging miR-103a-3p and regulating SIK2 expression.
Role of saltinducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.
Title: Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.
SIK2 orchestrates actin-dependent host response upon Salmonella infection.
Title: SIK2 orchestrates actin-dependent host response upon Salmonella infection.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH99301 (e-PCR)
- UniSTS:91145

WI-15500 (e-PCR)
- UniSTS:32301

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

sY3084 (e-PCR)
- UniSTS:515126

D11S966E (e-PCR)
- UniSTS:147785

A008R11 (e-PCR)
- UniSTS:60773

WI-14282 (e-PCR)
- UniSTS:47723

SHGC-58333 (e-PCR)
- UniSTS:94316

A008B02 (e-PCR)
- UniSTS:65662

RH36390 (e-PCR)
- UniSTS:22142

G30492 (e-PCR)
- UniSTS:1919

NIB1902 (e-PCR)
- UniSTS:82581

STS-Z40795 (e-PCR)
- UniSTS:81605

SHGC-172824 (e-PCR)
- UniSTS:182486

SHGC-78845 (e-PCR)
- UniSTS:95703

STS-N25323 (e-PCR)
- UniSTS:38363

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase SIK2

Names: SNF1-like kinase 2; qin-induced kinase; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SNF1-like kinase 2

NP_056006.1

EC 2.7.11.1

XP_016872906.1

EC 2.7.11.1

XP_054224167.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015191.3 → NP_056006.1 serine/threonine-protein kinase SIK2

See identical proteins and their annotated locations for NP_056006.1

Status: VALIDATED

Source sequence(s)

AP000925

Consensus CDS

CCDS8347.1

UniProtKB/Swiss-Prot

A8K5B8, B0YJ94, O94878, Q17RV0, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8, Q9H0K1

Related

ENSP00000305976.3, ENST00000304987.4

Conserved Domains (2) summary

cd14409
Location:297 → 341

UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)

cd14071
Location:19 → 271

STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases