Format

Send to:

Choose Destination

A2m alpha-2-macroglobulin [ Mus musculus (house mouse) ]

Gene ID: 232345, updated on 8-Jul-2018
Official Symbol
A2mprovided by MGI
Official Full Name
alpha-2-macroglobulinprovided by MGI
Primary source
MGI:MGI:2449119
See related
Ensembl:ENSMUSG00000030111 Vega:OTTMUSG00000056872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A2mp
Expression
Biased expression in liver E18 (RPKM 215.0), placenta adult (RPKM 27.2) and 1 other tissue See more
See A2m in Genome Data Viewer
Location:
6 F1; 6 57.49 cM
Exon count:
37
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (121636166..121679238)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (121586191..121629256)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 Neighboring gene IQ motif and Sec7 domain 3 Neighboring gene murinoglobulin 1 pseudogene Neighboring gene thymosin beta-10 pseudogene Neighboring gene murinoglobulin 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
brain-derived neurotrophic factor binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-8 binding ISO
Inferred from Sequence Orthology
more info
 
nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
peptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of complement activation, lectin pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175628.3NP_783327.2  alpha-2-macroglobulin-P precursor

    See identical proteins and their annotated locations for NP_783327.2

    Status: VALIDATED

    Source sequence(s)
    AI850558, BC072642, BY785372, CN701262
    Consensus CDS
    CCDS39617.1
    UniProtKB/Swiss-Prot
    Q6GQT1
    Related
    ENSMUSP00000032203.7, OTTMUSP00000073543, ENSMUST00000032203.8, OTTMUST00000140274
    Conserved Domains (6) summary
    cd02897
    Location:9581264
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:738828
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:135227
    A2M_N; MG2 domain
    pfam07677
    Location:13761463
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10101266
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:473612
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    121636166..121679238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241322.1XP_011239624.1  alpha-2-macroglobulin-P isoform X1

    Conserved Domains (3) summary
    pfam00207
    Location:738828
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:135227
    A2M_N; MG2 domain
    pfam07703
    Location:473612
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
Support Center