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Wnk1 WNK lysine deficient protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 232341, updated on 7-Feb-2023

Summary

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Official Symbol
Wnk1provided by MGI
Official Full Name
WNK lysine deficient protein kinase 1provided by MGI
Primary source
MGI:MGI:2442092
See related
Ensembl:ENSMUSG00000045962 AllianceGenome:MGI:2442092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsn2; Prkwnk1; EG406236; mKIAA0344; 6430573H23Rik
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; lymphocyte migration into lymph node; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including negative regulation of GTPase activity; negative regulation of pancreatic juice secretion; and positive regulation of systemic arterial blood pressure. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 40.9), thymus adult (RPKM 32.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wnk1 in Genome Data Viewer
Location:
6; 6 F1
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119900930..120015659, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119923969..120038695, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A pseudogene Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene microRNA 706 Neighboring gene ninjurin 2 Neighboring gene predicted gene, 25327 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice. Hayward DA, et al. J Exp Med, 2023 Mar 6. PMID 36662229, Free PMC Article
  2. WNK1 in the kidney. Bahena-Lopez JP, et al. Curr Opin Nephrol Hypertens, 2022 Sep 1. PMID 35894282
  3. WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis. Jaykumar AB, et al. Proc Natl Acad Sci U S A, 2022 Jul 26. PMID 35867836, Free PMC Article
  4. Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1. Li Q, et al. Bioengineered, 2022 Jan. PMID 34967279, Free PMC Article
  5. L-WNK1 is required for BK channel activation in intercalated cells. Ray EC, et al. Am J Physiol Renal Physiol, 2021 Aug 1. PMID 34229479, Free PMC Article

See all (95) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
    Title: B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
  2. WNK1 in the kidney.
    Title: WNK1 in the kidney.
  3. WNK1 collaborates with TGF-beta in endothelial cell junction turnover and angiogenesis.
    Title: WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis.
  4. Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1.
    Title: Long noncoding RNA Gm44593 attenuates oxidative stress from age-related hearing loss by regulating miR-29b/WNK1.
  5. L-WNK1 is required for BK channel activation in intercalated cells.
    Title: L-WNK1 is required for BK channel activation in intercalated cells.
  6. Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
    Title: Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
  7. Role of KLHL3 and dietary K(+) in regulating KS-WNK1 expression.
    Title: Role of KLHL3 and dietary K(+) in regulating KS-WNK1 expression.
  8. Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
    Title: Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
  9. Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
    Title: Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
  10. Potassium acts through mTOR to regulate its own secretion.
    Title: Potassium acts through mTOR to regulate its own secretion.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC175896, MGC175898

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables chloride channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine (C-C motif) ligand 21 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular chloride ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphocyte migration into lymph node IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in monoatomic ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of pancreatic juice secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within positive regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of regulation of monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase WNK1
Names
protein kinase lysine-deficient 1
protein kinase with no lysine 1
NP_001171949.1
NP_001171950.1
NP_001186012.1
NP_001186013.1
NP_941992.2
XP_011239622.1
XP_017177031.1
XP_017177038.1
XP_017177039.1
XP_017177041.1
XP_017177043.1
XP_017177044.1
XP_017177045.1
XP_017177046.1
XP_030111215.1
XP_036021959.1
XP_036021960.1
XP_036021961.1
XP_036021962.1
XP_036021963.1
XP_036021964.1
XP_036021965.1
XP_036021966.1
XP_036021967.1
XP_036021968.1
XP_036021969.1
XP_036021970.1
XP_036021971.1
XP_036021972.1
XP_036021973.1
XP_036021974.1
XP_036021975.1
XP_036021976.1
XP_036021977.1
XP_036021978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185020.1 → NP_001171949.1  serine/threonine-protein kinase WNK1 isoform 2

    See identical proteins and their annotated locations for NP_001171949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 5.
    Source sequence(s)
    AK133738, BC056761, BC138445
    Consensus CDS
    CCDS85147.1
    UniProtKB/Swiss-Prot
    P83741
    Related
    ENSMUSP00000145304.2, ENSMUST00000203030.3
    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam09770
    Location:677 → 812
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  2. NM_001185021.1 → NP_001171950.1  serine/threonine-protein kinase WNK1 isoform 3

    See identical proteins and their annotated locations for NP_001171950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 5.
    Source sequence(s)
    AK133738, BC056761, BC145282
    Consensus CDS
    CCDS51888.1
    UniProtKB/Swiss-Prot
    P83741
    Related
    ENSMUSP00000086019.6, ENSMUST00000088646.12
    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  3. NM_001199083.1 → NP_001186012.1  serine/threonine-protein kinase WNK1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 5. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is shorter than isoform 5 but has the same N- and C-termini.
    Source sequence(s)
    AC113092, AK133738, BC054836, BC171955, CN693598
    Consensus CDS
    CCDS57445.1
    UniProtKB/Swiss-Prot
    P83741
    UniProtKB/TrEMBL
    Q7TPR2
    Related
    ENSMUSP00000136777.2, ENSMUST00000177761.8
    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  4. NM_001199084.1 → NP_001186013.1  serine/threonine-protein kinase WNK1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5). This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183.
    Source sequence(s)
    AC113092, AK133738, BC054836, BC145282, BC171955, CN693598
    Consensus CDS
    CCDS57444.1
    UniProtKB/Swiss-Prot
    P83741
    UniProtKB/TrEMBL
    Q7TPR2
    Related
    ENSMUSP00000086017.7, ENSMUST00000088644.13
    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  5. NM_198703.3 → NP_941992.2  serine/threonine-protein kinase WNK1 isoform 1

    See identical proteins and their annotated locations for NP_941992.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 5.
    Source sequence(s)
    AK133738, AY309076, BC056761, BC171955
    Consensus CDS
    CCDS20478.1
    UniProtKB/Swiss-Prot
    P83741, Q6VYA0
    Related
    ENSMUSP00000063001.7, ENSMUST00000060043.13
    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119900930..120015659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166066.1 → XP_036021959.1  serine/threonine-protein kinase WNK1 isoform X1

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1152 → 1564
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  2. XM_036166085.1 → XP_036021978.1  serine/threonine-protein kinase WNK1 isoform X30

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1066 → 1478
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  3. XM_017321556.1 → XP_017177045.1  serine/threonine-protein kinase WNK1 isoform X28

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  4. XM_030255355.1 → XP_030111215.1  serine/threonine-protein kinase WNK1 isoform X25

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  5. XM_036166084.1 → XP_036021977.1  serine/threonine-protein kinase WNK1 isoform X23

    Conserved Domains (3) summary
    PRK14949
    Location:587 → 957
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  6. XM_011241320.2 → XP_011239622.1  serine/threonine-protein kinase WNK1 isoform X20

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:646 → 1092
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  7. XM_017321557.1 → XP_017177046.1  serine/threonine-protein kinase WNK1 isoform X29

    UniProtKB/Swiss-Prot
    P83741
    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam09770
    Location:677 → 812
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  8. XM_017321555.1 → XP_017177044.1  serine/threonine-protein kinase WNK1 isoform X27

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam09770
    Location:677 → 812
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  9. XM_017321554.1 → XP_017177043.1  serine/threonine-protein kinase WNK1 isoform X26

    UniProtKB/Swiss-Prot
    P83741
    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  10. XM_017321552.1 → XP_017177041.1  serine/threonine-protein kinase WNK1 isoform X24

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  11. XM_017321550.1 → XP_017177039.1  serine/threonine-protein kinase WNK1 isoform X22

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  12. XM_017321549.1 → XP_017177038.1  serine/threonine-protein kinase WNK1 isoform X21

    UniProtKB/Swiss-Prot
    P83741, Q6VYA0
    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  13. XM_017321542.3 → XP_017177031.1  serine/threonine-protein kinase WNK1 isoform X19

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  14. XM_036166082.1 → XP_036021975.1  serine/threonine-protein kinase WNK1 isoform X17

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  15. XM_036166079.1 → XP_036021972.1  serine/threonine-protein kinase WNK1 isoform X14

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  16. XM_036166076.1 → XP_036021969.1  serine/threonine-protein kinase WNK1 isoform X11

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1066 → 1478
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  17. XM_036166081.1 → XP_036021974.1  serine/threonine-protein kinase WNK1 isoform X16

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  18. XM_036166067.1 → XP_036021960.1  serine/threonine-protein kinase WNK1 isoform X2

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1152 → 1563
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  19. XM_036166083.1 → XP_036021976.1  serine/threonine-protein kinase WNK1 isoform X18

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  20. XM_036166080.1 → XP_036021973.1  serine/threonine-protein kinase WNK1 isoform X15

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  21. XM_036166078.1 → XP_036021971.1  serine/threonine-protein kinase WNK1 isoform X13

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  22. XM_036166077.1 → XP_036021970.1  serine/threonine-protein kinase WNK1 isoform X12

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  23. XM_036166075.1 → XP_036021968.1  serine/threonine-protein kinase WNK1 isoform X10

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  24. XM_036166071.1 → XP_036021964.1  serine/threonine-protein kinase WNK1 isoform X6

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1152 → 1564
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  25. XM_036166074.1 → XP_036021967.1  serine/threonine-protein kinase WNK1 isoform X9

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  26. XM_036166073.1 → XP_036021966.1  serine/threonine-protein kinase WNK1 isoform X8

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  27. XM_036166072.1 → XP_036021965.1  serine/threonine-protein kinase WNK1 isoform X7

    Conserved Domains (2) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  28. XM_036166070.1 → XP_036021963.1  serine/threonine-protein kinase WNK1 isoform X5

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1152 → 1564
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  29. XM_036166068.1 → XP_036021961.1  serine/threonine-protein kinase WNK1 isoform X3

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1152 → 1564
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  30. XM_036166069.1 → XP_036021962.1  serine/threonine-protein kinase WNK1 isoform X4

    Conserved Domains (3) summary
    cd14030
    Location:195 → 483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam03154
    Location:1152 → 1564
    Atrophin-1; Atrophin-1 family
    pfam12202
    Location:500 → 563
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037155.1: Suppressed sequence

    Description
    NM_001037155.1: This RefSeq was permanently suppressed because it represents a nervous system-specific exon of WNK1, GeneID 232341, but there currently is insufficient support for a transcript containing this exon.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83741.2 GenPept UniProtKB/Swiss-Prot:P83741

Gene LinkOut

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