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Ankrd26 ankyrin repeat domain 26 [ Mus musculus (house mouse) ]

Gene ID: 232339, updated on 8-Feb-2024

Summary

Official Symbol
Ankrd26provided by MGI
Official Full Name
ankyrin repeat domain 26provided by MGI
Primary source
MGI:MGI:1917887
See related
Ensembl:ENSMUSG00000007827 AllianceGenome:MGI:1917887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1074; 5730521P14Rik
Summary
Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin cytoskeleton. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including ANKRD26 (ankyrin repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.4), CNS E14 (RPKM 3.8) and 19 other tissues See more
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Genomic context

See Ankrd26 in Genome Data Viewer
Location:
6 F1; 6 55.86 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118478261..118539244, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118501300..118562280, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 248 pseudogene Neighboring gene zinc finger protein 9 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene predicted gene, 38887 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081112.2NP_001074581.1  ankyrin repeat domain-containing protein 26

    Status: VALIDATED

    Source sequence(s)
    AC036121, AC140192
    Consensus CDS
    CCDS39609.1
    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    UniProtKB/TrEMBL
    D3Z482
    Related
    ENSMUSP00000108449.2, ENSMUST00000112830.3
    Conserved Domains (8) summary
    COG1340
    Location:11971457
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00204
    Location:75200
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12001
    Location:14951602
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:51101
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:8861189
    CCDC144C; CCDC144C protein coiled-coil region
    sd00045
    Location:82111
    ANK; ANK repeat [structural motif]
    cl21509
    Location:11951329
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    118478261..118539244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506023.4XP_006506086.1  ankyrin repeat domain-containing protein 26 isoform X2

    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    Conserved Domains (6) summary
    PLN03192
    Location:54277
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG1196
    Location:6901521
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:82111
    ANK; ANK repeat [structural motif]
    pfam12001
    Location:14621569
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85177
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:8531156
    CCDC144C; CCDC144C protein coiled-coil region
  2. XM_006506022.4XP_006506085.1  ankyrin repeat domain-containing protein 26 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    Conserved Domains (6) summary
    PLN03192
    Location:54277
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG1196
    Location:7281559
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:82111
    ANK; ANK repeat [structural motif]
    pfam12001
    Location:15001607
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85177
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:8911194
    CCDC144C; CCDC144C protein coiled-coil region
  3. XM_036166065.1XP_036021958.1  ankyrin repeat domain-containing protein 26 isoform X6

    Conserved Domains (3) summary
    COG1196
    Location:3051136
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:10771184
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:468772
    CCDC144C; CCDC144C protein coiled-coil region
  4. XM_036166064.1XP_036021957.1  ankyrin repeat domain-containing protein 26 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:3381169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:11101217
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:501805
    CCDC144C; CCDC144C protein coiled-coil region
  5. XM_030255354.2XP_030111214.1  ankyrin repeat domain-containing protein 26 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:3431174
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:11151222
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:506809
    CCDC144C; CCDC144C protein coiled-coil region
  6. XM_006506025.4XP_006506088.1  ankyrin repeat domain-containing protein 26 isoform X7

    Conserved Domains (3) summary
    COG1196
    Location:2401071
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12001
    Location:10121119
    DUF3496; Domain of unknown function (DUF3496)
    pfam14915
    Location:403706
    CCDC144C; CCDC144C protein coiled-coil region
  7. XM_006506024.4XP_006506087.1  ankyrin repeat domain-containing protein 26 isoform X3

    UniProtKB/Swiss-Prot
    Q69ZS2, Q811D2, Q9CS61
    Conserved Domains (6) summary
    PLN03192
    Location:54277
    PLN03192; Voltage-dependent potassium channel; Provisional
    COG1196
    Location:660930
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:11041300
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    sd00045
    Location:82111
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:85177
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:8911194
    CCDC144C; CCDC144C protein coiled-coil region

RNA

  1. XR_001785122.3 RNA Sequence